Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Hendrik Gille"'
Autor:
Reinhard Meier, Rickmer Braren, Yvonne Kosanke, Johanna Bussemer, Frauke Neff, Moritz Wildgruber, Sarah Schwarzenböck, Annette Frank, Bernhard Haller, Andreas M Hohlbaum, Markus Schwaiger, Hendrik Gille, Ernst J Rummeny, Ambros J Beer
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e94972 (2014)
Anticalins are a novel class of targeted protein therapeutics. The PEGylated Anticalin Angiocal (PRS-050-PEG40) is directed against VEGF-A. The purpose of our study was to compare the performance of diffusion weighted imaging (DWI), dynamic contrast
Externí odkaz:
https://doaj.org/article/5fa91d33401c4942959a4d6698927875
Autor:
Coby M M Laarakkers, Erwin T Wiegerinck, Siem Klaver, Maria Kolodziejczyk, Hendrik Gille, Andreas M Hohlbaum, Harold Tjalsma, Dorine W Swinkels
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75518 (2013)
Mass spectrometry (MS)-based assays for the quantification of the iron regulatory hormone hepcidin are pivotal to discriminate between the bioactive 25-amino acid form that can effectively block the sole iron transporter ferroportin and other natural
Externí odkaz:
https://doaj.org/article/6cfd25e9d8fa454cae307698a42af99f
Autor:
Klaus Mross, Heike Richly, Richard Fischer, Dirk Scharr, Martin Büchert, Angelika Stern, Hendrik Gille, Laurent P Audoly, Max E Scheulen
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83232 (2013)
To report the nonrandomized first-in-human phase I trial of PRS-050, a novel, rationally engineered Anticalin based on human tear lipocalin that targets and antagonizes vascular endothelial growth factor A (VEGF-A).Patients with advanced solid tumors
Externí odkaz:
https://doaj.org/article/8cd061a0411d46768cf4d41e3c792632
Autor:
Laurent Audoly, Andreas M. Hohlbaum, Kristian Jensen, Stefan Trentmann, Martin Hülsmeyer, Hans Jürgen Christian, Cristina Chiriaco, James F. Burrows, Jakub Jaworski, Bradley M. Lunde, Andrea Allersdorfer, Gabriele Matschiner, Elisa Vigna, Hendrik Gille, Christian Joffroy, Shane A. Olwill
PDF - 53KB, Demonstration of benign immunogenicity profile of PRS-110 in ex vivo PBMC model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8881e0a9ed9ca395a29f3c3f74ef5f
https://doi.org/10.1158/1535-7163.22497609
https://doi.org/10.1158/1535-7163.22497609
Autor:
Laurent Audoly, Andreas M. Hohlbaum, Kristian Jensen, Stefan Trentmann, Martin Hülsmeyer, Hans Jürgen Christian, Cristina Chiriaco, James F. Burrows, Jakub Jaworski, Bradley M. Lunde, Andrea Allersdorfer, Gabriele Matschiner, Elisa Vigna, Hendrik Gille, Christian Joffroy, Shane A. Olwill
Text legends for each supplementary figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794a6d32e65f586163242836d3d88823
https://doi.org/10.1158/1535-7163.22497612.v1
https://doi.org/10.1158/1535-7163.22497612.v1
Autor:
Laurent Audoly, Andreas M. Hohlbaum, Kristian Jensen, Stefan Trentmann, Martin Hülsmeyer, Hans Jürgen Christian, Cristina Chiriaco, James F. Burrows, Jakub Jaworski, Bradley M. Lunde, Andrea Allersdorfer, Gabriele Matschiner, Elisa Vigna, Hendrik Gille, Christian Joffroy, Shane A. Olwill
Activation of the MET oncogenic pathway has been implicated in the development of aggressive cancers that are difficult to treat with current chemotherapies. This has led to an increased interest in developing novel therapies that target the MET path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a821aea4ee00d0263cf8b1d610c19bd9
https://doi.org/10.1158/1535-7163.c.6535668.v1
https://doi.org/10.1158/1535-7163.c.6535668.v1
Autor:
Laurent Audoly, Andreas M. Hohlbaum, Kristian Jensen, Stefan Trentmann, Martin Hülsmeyer, Hans Jürgen Christian, Cristina Chiriaco, James F. Burrows, Jakub Jaworski, Bradley M. Lunde, Andrea Allersdorfer, Gabriele Matschiner, Elisa Vigna, Hendrik Gille, Christian Joffroy, Shane A. Olwill
PDF - 31KB, Characterisation of cell line panel for MET and HGF expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564d00594a764a618dcb5f852ed7ca37
https://doi.org/10.1158/1535-7163.22497618
https://doi.org/10.1158/1535-7163.22497618
Autor:
Laurent Audoly, Andreas M. Hohlbaum, Kristian Jensen, Stefan Trentmann, Martin Hülsmeyer, Hans Jürgen Christian, Cristina Chiriaco, James F. Burrows, Jakub Jaworski, Bradley M. Lunde, Andrea Allersdorfer, Gabriele Matschiner, Elisa Vigna, Hendrik Gille, Christian Joffroy, Shane A. Olwill
PDF - 136KB, Demonstration of PRS-110 dependent MET trafficking in HT29 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7500d20ba1919fe47d49bea85c5b18a5
https://doi.org/10.1158/1535-7163.22497615.v1
https://doi.org/10.1158/1535-7163.22497615.v1
Autor:
Gabriele Matschiner, Mary F. Fitzgerald, Ulrich Moebius, Andreas M. Hohlbaum, Hendrik Gille, Kristian Jensen, Klaus Kirchfeld, Barbara Rattenstetter, Alice Laforge, Rachida S. Bel Aiba, Joe Ciccotosto, Hong Nyugen, Martyn L. Foster, John N. Snouwaert, MyTrang Nguyen, Beverly H. Koller, Louis Matis, Gary P. Anderson, Shane A. Olwill
Publikováno v:
The Journal of allergy and clinical immunology.
T2 endotype asthma is driven by IL-4 and IL-13 signaling via IL-4Ra, which is highly expressed on airway epithelium, airway smooth muscle and immunocytes in the respiratory mucosa, suggesting potential advantages of an inhalable antagonist. Lipocalin
Autor:
Nicole Andersen, Rachel P. L. van Swelm, Hendrik Gille, Bernd Meibohm, Dorine W. Swinkels, Andrea Allersdorfer, Andreas Hohlbaum, Maria Kolodziejczyk, Laurent P. Audoly, Galina Katzmann, Shane A. Olwill, Hans Jürgen Christian, Barbara Rattenstetter, Stefan Trentmann, Coby M. Laarakkers
Publikováno v:
British Journal of Pharmacology. 175:1054-1065
Background and Purpose Anaemia of chronic disease (ACD) has been linked to iron-restricted erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte-derived peptide that controls systemic iron homeostasis. Here, we rep