Zobrazeno 1 - 10
of 392
pro vyhledávání: '"Hendrik G, Stunnenberg"'
Autor:
Joshua Gillard, Madeleine Suffiotti, Peter Brazda, Prashanna B. Venkatasubramanian, Pauline Versteegen, Marien I. de Jonge, Dominic Kelly, Sagida Bibi, Marta Valente Pinto, Elles Simonetti, Mihaela Babiceanu, Andrew Kettring, Cristina Teodosio, Ronald de Groot, Guy Berbers, Hendrik G. Stunnenberg, Brian Schanen, Craig Fenwick, Martijn A. Huynen, Dimitri A. Diavatopoulos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Many countries continue to experience pertussis epidemics despite widespread vaccination. Waning protection after booster vaccination has highlighted the need for a better understanding of the immunological factors that promote durable prote
Externí odkaz:
https://doaj.org/article/070c1fead68940ffb909a241214acbe3
Autor:
Jason P. Wray, Elitza M. Deltcheva, Charlotta Boiers, Simon Е Richardson, Jyoti Bikram Chhetri, John Brown, Sladjana Gagrica, Yanping Guo, Anuradha Illendula, Joost H. A. Martens, Hendrik G. Stunnenberg, John H. Bushweller, Rachael Nimmo, Tariq Enver
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The ETV6-RUNX1 chimeric- and native RUNX1-responsive regulomes in paediatric B-acute lymphoblastic leukemia (B-ALL) remain to be characterized. Here, the authors reveal functional antagonism between the two transcription factors predominantly for the
Externí odkaz:
https://doaj.org/article/57a324404a3a49c69acb08a4d571d807
Autor:
Yanan Zhai, Prashant Singh, Anna Dolnik, Peter Brazda, Nader Atlasy, Nunzio del Gaudio, Konstanze Döhner, Hartmut Döhner, Saverio Minucci, Joost Martens, Lucia Altucci, Wout Megchelenbrink, Lars Bullinger, Hendrik G. Stunnenberg
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background Acute myeloid leukemia (AML) is a heterogeneous and aggressive blood cancer that results from diverse genetic aberrations in the hematopoietic stem or progenitor cells (HSPCs) leading to the expansion of blasts in the hematopoieti
Externí odkaz:
https://doaj.org/article/cdc5c6225a8845a29d882f5c207da3a3
Autor:
Nader Atlasy, Anna Bujko, Espen S. Bækkevold, Peter Brazda, Eva Janssen-Megens, Knut E. A. Lundin, Jørgen Jahnsen, Frode L. Jahnsen, Hendrik G. Stunnenberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Celiac disease is linked to responsiveness to dietary gluten, which manifests itself as immune cell activation and the immunopathology including destruction of the epithelium of the small intestine. Here the authors apply single cell transcriptomics
Externí odkaz:
https://doaj.org/article/578cbe1cdf2341e7b143bf5553092388
Autor:
Nunzio Del Gaudio, Antonella Di Costanzo, Ning Qing Liu, Lidio Conte, Carmela Dell’Aversana, Guglielmo Bove, Rosaria Benedetti, Liliana Montella, Fortunato Ciardiello, Vincenzo Carafa, Concetta Ambrosino, Valeria Tucci, Mariarosaria Conte, Joost H. A. Martens, Hendrik G. Stunnenberg, Angela Nebbioso, Lucia Altucci
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovered chromatin readers i
Externí odkaz:
https://doaj.org/article/07529a4a602742c3a53ad8261632a83c
Autor:
Angelita Poziello, Angela Nebbioso, Hendrik G. Stunnenberg, Joost H.A. Martens, Vincenzo Carafa, Lucia Altucci
Publikováno v:
Epigenetics, Vol 16, Iss 8, Pp 838-850 (2021)
Acetylation of histone and non-histone proteins is a post-translational modification mostly associated with activation of gene transcription. The first histone acetyltransferase (HAT) identified as modifying newly synthesized histone H4 in yeast was
Externí odkaz:
https://doaj.org/article/2163b107ca3d4a5d8ba88f2dbb9cd4e6
Autor:
Peter Brazda, Cristian Ruiz-Moreno, Wout L. Megchelenbrink, Henri J. L. M. Timmers, Hendrik G. Stunnenberg
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Pheochromocytomas (PC) and paragangliomas (PG) are rare neuroendocrine tumors with varied genetic makeup and are associated with high cardiovascular morbidity and a variable risk of malignancy. The source of the transcriptional heterogeneity of the d
Externí odkaz:
https://doaj.org/article/8b4e2d0db1f646909769e70a7e9c8113
Autor:
Roser Vilarrasa-Blasi, Paula Soler-Vila, Núria Verdaguer-Dot, Núria Russiñol, Marco Di Stefano, Vicente Chapaprieta, Guillem Clot, Irene Farabella, Pol Cuscó, Marta Kulis, Xabier Agirre, Felipe Prosper, Renée Beekman, Silvia Beà, Dolors Colomer, Hendrik G. Stunnenberg, Ivo Gut, Elias Campo, Marc A. Marti-Renom, José Ignacio Martin-Subero
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D g
Externí odkaz:
https://doaj.org/article/5b3e5737815642a5840183e2effa2f69
Autor:
Tianran Peng, Yanan Zhai, Yaser Atlasi, Menno ter Huurne, Hendrik Marks, Hendrik G. Stunnenberg, Wout Megchelenbrink
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-27 (2020)
Abstract Background Enhancers are distal regulators of gene expression that shape cell identity and control cell fate transitions. In mouse embryonic stem cells (mESCs), the pluripotency network is maintained by the function of a complex network of e
Externí odkaz:
https://doaj.org/article/a7e5bc5ab6f847d9aaa8ed8f93c3acaf
Autor:
Yaser Atlasi, Seyed Mehdi Jafarnejad, Christos G. Gkogkas, Michiel Vermeulen, Nahum Sonenberg, Hendrik G. Stunnenberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Translational control of gene expression can lead to significant divergence between mRNA and protein abundance. Here, the authors describe transcriptional rewiring and translational buffering during transition from naïve to primed pluripotency throu
Externí odkaz:
https://doaj.org/article/5995ba7b3371459d9c0c5530ed92ef7b