Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hendrik Falk"'
Autor:
Isabella Y. Kong, Joel S. Rimes, Amanda Light, Izabela Todorovski, Sarah Jones, Eric Morand, Deborah A. Knight, Ylva E. Bergman, Simon J. Hogg, Hendrik Falk, Brendon J. Monahan, Paul A. Stupple, Ian P. Street, Susanne Heinzel, Philippe Bouillet, Ricky W. Johnstone, Philip D. Hodgkin, Stephin J. Vervoort, Edwin D. Hawkins
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108290- (2020)
Summary: JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody production is not understood. Our results show that JQ1 induces apoptosis, reduces
Externí odkaz:
https://doaj.org/article/ee968f52f07046a6b68bf519b3e86ce7
Autor:
Ian P. Street, Benjamin Cleary, Jonathan B. Baell, Jessica M. Strasser, Daniel L. Priebbenow, Hendrik Falk, Michael W. Parker, Susan A. Charman, H. Rachel Lagiakos, Brendon J. Monahan, Michael A. Walters, M.C. Chung, S.J. Hermans, Natalie L. Downer, Matthew E. Cuellar, Jayme L. Dahlin, Helene Jousset Sabroux, Tim Thomas, David J. Leaver, Swapna Varghese, Lian Xue, Karen L. White, Yuxin Sun, Prashant Mujumdar, Kasiram Katneni, Silvia Teguh, Anne K. Voss, Julie Sanchez, Kate E. Jarman, David M. Shackleford, Fei Huang, Ramesh Mudududdla, Nghi Nguyen
Publikováno v:
Journal of Medicinal Chemistry. 63:4655-4684
A high-throughput screen designed to discover new inhibitors of histone acetyltransferase KAT6A uncovered CTX-0124143 (1), a unique aryl acylsulfonohydrazide with an IC50 of 1.0 μM. Using this acylsulfonohydrazide as a template, we herein disclose t
Autor:
Ygal Haupt, Prerana Ghosh, Carleen Cullinane, Natalie Brajanovski, Gretchen Poortinga, Ian P. Street, Emily J. Lelliott, Laura Kirby, Keefe T. Chan, Mark G. Devlin, Richard B. Pearson, Elaine Sanij, Shatha AbuHammad, Lorey K. Smith, Michael A. Davies, Anthony T. Papenfuss, Alison Slater, Kerry Ardley, Sue Haupt, Karen E. Sheppard, Peter Lau, David J. Curtis, Hendrik Falk, Stupple Paul Anthony, Huiqin Chen, Grant A. McArthur, Margarete Kleinschmidt, Zoe Bacolas, Teresa Ward, Claire Martin, Aparna D. Rao, Ismael A. Vergara
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Targeting CDK4/6 shows great promise in the treatment of many solid cancers, including melanoma. This study has uncovered a mechanism of action of CDK4/6 inhibitors in regulating the MDM4 oncogene and the tumor suppressor, p53. In melano
Autor:
Melanie de Silva, Stewart D. Nuttall, Chen Fang Weng, Bin Ren, Paul Stupple, Mark A. Dawson, Annabelle Hoegl, Tim Thomas, Kathy Knezevic, Ian P. Street, George S. Vassiliou, Catalina Carrasco-Pozo, Yuqing Yang, Marnie E. Blewitt, Tracy A. Willson, Christopher J. Burns, Kah Lok Chan, Juliana Anokye, Linden J. Gearing, Thomas S. Peat, Janet Newman, Olan Dolezal, Oliver M. Dovey, Regina Surjadi, Miriam S. Butler, Laura MacPherson, Paul Yeh, Vicky M. Avery, Jonathan B. Baell, Enid Y.N. Lam, Yuxin Sun, Anne K. Voss, Nghi H. Nguyen, Ming Zhang, Matthew L. Dennis, Hendrik Falk, Rebecca A. Bilardi, Poh Sim Khoo, Marian L. Burr, Brendon J. Monahan, Miriam M. Yeung, Jarny Choi, Yih-Chih Chan, Chunaram Choudhary, Florian Grebien, Sarah-Jane Dawson, Joy Liu, David J. Leaver
Publikováno v:
MacPherson, L, Anokye, J, Yeung, M M, Lam, E Y N, Chan, Y-C, Weng, C-F, Yeh, P, Knezevic, K, Butler, M S, Hoegl, A, Chan, K-L, Burr, M L, Gearing, L J, Willson, T, Liu, J, Choi, J, Yang, Y, Bilardi, R A, Falk, H, Nghi Nguyen, Stupple, P A, Peat, T S, Zhang, M, De Silva, M, Carrasco-Pozo, C, Avery, V M, Khoo, S, Dolezal, O, Dennis, M L, Nuttall, S, Surjadi, R, Newman, J, Ren, B, Leaver, D J, Sun, Y, Baell, J B, Dovey, O, Vassiliou, G S, Grebien, F, Dawson, S-J, Street, I P, Monahan, B J, Burns, C J, Choudhary, C, Blewitt, M E, Voss, A K, Thomas, T & Dawson, M A 2020, ' HBO1 is required for the maintenance of leukaemia stem cells ', Nature, vol. 577, no. 7789, pp. 266-270 . https://doi.org/10.1038/s41586-019-1835-6
Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3bc6f449feaabadd1fab4f6f8e7cdc
Autor:
Helen M. McRae, Ian P. Street, John D. Bentley, Edwin D. Hawkins, Brandon J. Aubrey, Karen L. White, Bin Ren, Matthew L. Dennis, Meghan Hattarki, Stephen Mieruszynski, Natasha Zamudio, Gordon K. Smyth, M.C. Chung, Andrew J. Sealey, Maria I. Bergamasco, Guido Pacini, Natalie L. Downer, Jonathan B. Baell, Andreas Strasser, Jai Rautela, Ricky W. Johnstone, Nghi H. Nguyen, Alexandra L. Garnham, Bilal N. Sheikh, Andrea Newbold, Gemma L. Kelly, David J. Leaver, Pat Pilling, Rose E. May, Nicholas D. Huntington, Johannes Wichmann, Yuquing Yang, Tim Thomas, S.J. Hermans, Hannah K. Vanyai, Anne K. Voss, Beinan Wang, H. Rachel Lagiakos, Brendon J. Monahan, Bethany K. Davey, Stephen Wilcox, Melanie de Silva, Olan Dolezal, Michael W. Parker, Susan A. Charman, Margs S. Brennan, Kimberly J. Morgan, Karen Doggett, Joan K. Heath, Thomas S. Peat, Benjamin Cleary, Hendrik Falk
Publikováno v:
Nature. 560:253-257
Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function1. Among the genes coding for the MYST family of KATs (KAT5-KAT8) are the oncogenes KAT6A (also known as MOZ) and KAT6B (also known as MOR
Autor:
Karen L. White, Sean Uryu, Pei-Pei Kung, Melanie de Silva, Ian P. Street, Hieu Lam, Jane E. Visvader, Ylva E. Bozikis, Catalina Carrasco-Pozo, Karen A. Maegley, Geoffrey J. Lindeman, Shikhar Sharma, Anne K. Voss, Paul Stupple, Natalie Nady, Elizabeth Allan, Olan Dolezal, Chin Wee Tan, Elliot Surgenor, Yong Zhang, Alexandra E. Stupple, Yuqing Yang, Amanda Rickard, Michelle Ang Camerino, Brendon J. Monahan, Showkhin Khan, Thomas A Paul, Hendrik Falk, François Vaillant, Laura MacPherson, Zhenxiong Wang, Dawson Sarah-Jane, James R. Whittle, Jay Chung, Melissa J. Davis, Mark A. Dawson, Eric Greenwald, Thomas S. Peat, Vicky M. Avery, Tim Thomas, Haikuo Zhang, Rachel Lagiakos, Patrick Bingham, Matthew L. Dennis, Bin Ren, Miriam S. Butler, Susan A. Charman, Soroor Hediyeh-Zadeh, Stewart D. Nuttall
Publikováno v:
Cancer Research. 81:1130-1130
KAT6A is a lysine histone acetyltransferase (HAT) of the MYST family of HATs. KAT6A, and its paralog KAT6B, have been shown to acetylate histone H3K23Ac and regulate diverse biological processes, including transcription, cell-cycle progression, stem
Autor:
Paul Stupple, Deborah A. Knight, Ian P. Street, Isabella Y. Kong, Sarah Jones, Ylva Elisabet Bergman, Hendrik Falk, Philip D. Hodgkin, Joel S. Rimes, Edwin D. Hawkins, Stephin J. Vervoort, Eric F Morand, Ricky W. Johnstone, Brendon J. Monahan, Philippe Bouillet, Izabela Todorovski, Susanne Heinzel, Amanda Light, Simon J. Hogg
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108290-(2020)
Summary: JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody production is not understood. Our results show that JQ1 induces apoptosis, reduces
Autor:
Kurt Lackovic, Ian P. Street, Karl-Johan Leuchowius, Guillaume Lessene, Jonathan B. Baell, Hendrik Falk
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 17:241-252
The Walter and Eliza Hall Institute of Medical Research (WEHI) is Australia's longest serving medical research institute. WEHI's High Throughput Screening (HTS) Facility was established in 2003 with $5 million of infrastructure funds invested by WEHI
Autor:
Ian P. Street, David J. Curtis, Paul Stupple, Stephen M. Jane, Benjamin Nicholson, Loretta Cerruti, Cedric S. Tremblay, Stefan Eugen Sonderegger, Emma Toulmin, Tom Nebl, Hendrik Falk, Katherine M. Hannan, Ashwin Unnikrishnan, Jesslyn Saw, Steven W. Lane, Rachel Altura
Publikováno v:
Blood. 132:53-53
Background: Myeloproliferative neoplasms (MPN) are a diverse group of hematopoietic stem cell disorders. JAK2V617F gain-of-function is the most prevalent mutation, accounting for more than 60% of MPNs. PRMT5 was initially identified as a JAK-binding
Autor:
Luxi Zhang, Scott Raymond Walker, Wilhelmus J A Kersten, Ian P. Street, Lynda Allan, Hendrik Falk, Patricia A. Pilling, Thomas S. Peat, I. Holmes, Theresa Connor, John D. Bentley, Naveid A. Ali, Jianmin Wu, Roger J. Daly, Melanie de Silva, Falko Hochgräfe, Emily S. Humphrey, Brendon J. Monahan
Publikováno v:
Journal of Proteome Research. 12:3104-3116
Kinase enrichment utilizing broad-spectrum kinase inhibitors enables the identification of large proportions of the expressed kinome by mass spectrometry. However, the existing inhibitors are still inadequate in covering the entire kinome. Here, we i