Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Hendrik Luesch"'
Autor:
Kalina R. Atanasova, Corey M. Perkins, Ranjala Ratnayake, Jinmai Jiang, Qi-Yin Chen, Thomas D. Schmittgen, Hendrik Luesch
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Acinar ductal metaplasia (ADM) is among the earliest initiating events in pancreatic ductal adenocarcinoma (PDAC) development.Methods: We developed a novel morphology-based screen using organoids from wildtype and p48Cre/+ (Cre) mice to d
Externí odkaz:
https://doaj.org/article/4d7b72a8149a4d8f90661d96456d3dea
Autor:
Lais da Silva, Jinmai Jiang, Corey Perkins, Kalina Rosenova Atanasova, Julie K. Bray, Gamze Bulut, Ana Azevedo-Pouly, Martha Campbell-Thompson, Xiaozhi Yang, Hesamedin Hakimjavadi, Srikar Chamala, Ranjala Ratnayake, Raad Z. Gharaibeh, Chenglong Li, Hendrik Luesch, Thomas D. Schmittgen
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Pancreatic acinar cells display a remarkable degree of plasticity and can dedifferentiate into ductal-like progenitor cells by a process known as acinar ductal metaplasia (ADM). ADM is believed to be one of the earliest precursor lesions tow
Externí odkaz:
https://doaj.org/article/7f68709dca8b439d9401f8575221c64b
Publikováno v:
Marine Drugs, Vol 22, Iss 1, p 28 (2023)
NMR and MS/MS-based metabolomics of a cyanobacterial extract from Piti Bomb Holes, Guam, indicated the presence of unique enyne-containing halogenated fatty acid amides. We isolated three new compounds of this class, taveuniamides L-N (1–3), along
Externí odkaz:
https://doaj.org/article/a0cdf73fa7204c4eb305df711c02fbd4
Autor:
Fatma H. Al-Awadhi, Emily F. Simon, Na Liu, Ranjala Ratnayake, Valerie J. Paul, Hendrik Luesch
Publikováno v:
Marine Drugs, Vol 21, Iss 11, p 553 (2023)
The monounsaturated fatty acid 7(E)-9-keto-hexadec-7-enoic acid (1) and three structurally related analogues with different oxidation states and degrees of unsaturation (2–4) were discovered from a marine benthic cyanobacterial mat collected from D
Externí odkaz:
https://doaj.org/article/03f90d49ecf34916946c0358955926d2
Publikováno v:
Marine Drugs, Vol 21, Iss 7, p 378 (2023)
Marine cyanobacteria are a rich source of bioactive natural products. Here, we report the isolation and structure elucidation of the previously reported iezoside (1) and its C-31 O-demethyl analogue, iezoside B (2), from a cyanobacterial assemblage c
Externí odkaz:
https://doaj.org/article/78f4c88a93af499eb8b50f9c854a8217
Autor:
Yuvixza Lizarme-Salas, Alexandra Daryl Ariawan, Ranjala Ratnayake, Hendrik Luesch, Angela Finch, Luke Hunter
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2663-2670 (2020)
Piperine, a natural product derived from peppercorns, has a variety of biological activities that make it an attractive lead compound for medicinal chemistry. However, piperine has some problematic physicochemical properties including poor aqueous so
Externí odkaz:
https://doaj.org/article/42e3bb5aa4d2484d8ce4736cb8375a10
Autor:
Dipesh Dhakal, Dimitris Kallifidas, Manyun Chen, Sofia Kokkaliari, Qi-Yin Chen, Valerie J. Paul, Yousong Ding, Hendrik Luesch
Publikováno v:
Organic Letters. 25:2238-2242
Autor:
Weijing Cai, Ranjala Ratnayake, Mengxiong Wang, Qi-Yin Chen, Kevin P. Raisch, Long H. Dang, Brian K. Law, Hendrik Luesch
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 2, Iss , Pp 100053- (2021)
Receptor tyrosine kinases (RTKs) have become major targets for anticancer therapy. However, resistance and signaling pathway redundancy has been problematic. The marine-derived apratoxins act complementary to direct kinase inhibitors by downregulatin
Externí odkaz:
https://doaj.org/article/163aeccd09774866bf50a672b5cff55c
Autor:
Sarath P. Gunasekera, Sofia Kokkaliari, Ranjala Ratnayake, Thomas Sauvage, Larissa A. H. dos Santos, Hendrik Luesch, Valerie J. Paul
Publikováno v:
Molecules, Vol 27, Iss 5, p 1717 (2022)
Dysidazirine carboxylic acid (1) was isolated from the lipophilic extract of a collection of the benthic marine cyanobacterium Caldora sp. from reefs near Fort Lauderdale, Florida. The planar structure of this new compound was determined by spectrosc
Externí odkaz:
https://doaj.org/article/af98e63ba9354bd4b8efe563ae59135a
Autor:
Dipesh Dhakal, Sofia Kokkaliari, Garret M. Rubin, Valerie J. Paul, Yousong Ding, Hendrik Luesch
Publikováno v:
Journal of Natural Products. 86:85-93