Zobrazeno 1 - 10
of 853
pro vyhledávání: '"Hendrik Lehnert"'
Autor:
Christin Krause, Jan H Britsemmer, Miriam Bernecker, Anna Molenaar, Natalie Taege, Nuria Lopez-Alcantara, Cathleen Geißler, Meike Kaehler, Katharina Iben, Anna Judycka, Jonas Wagner, Stefan Wolter, Oliver Mann, Paul Pfluger, Ingolf Cascorbi, Hendrik Lehnert, Kerstin Stemmer, Sonja C Schriever, Henriette Kirchner
Publikováno v:
eLife, Vol 12 (2024)
Background: The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach to map T2D induced changes in t
Externí odkaz:
https://doaj.org/article/61a65780677c4d41af349194722f905a
Autor:
Viridiana Alcántara-Alonso, Robert Dallmann, Hendrik Lehnert, Patricia de Gortari, Dimitris K. Grammatopoulos
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
The hypothalamic type 2 corticotropin releasing hormone receptor (CRH-R2) plays critical roles in homeostatic regulation, particularly in fine tuning stress recovery. During acute stress, the CRH-R2 ligands CRH and urocortins promote adaptive respons
Externí odkaz:
https://doaj.org/article/b7eead883b35470fb22c17ecd9162252
Autor:
Hendrik Ungefroren, Julissa Reimann, Björn Konukiewitz, Rüdiger Braun, Ulrich F. Wellner, Hendrik Lehnert, Jens-Uwe Marquardt
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 199 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type characterized by a marked desmoplastic tumor stroma that is formed under the influence of transforming growth factor (TGF)-β. Data from mouse models of pancreatic cancer have
Externí odkaz:
https://doaj.org/article/75f8d918348c4e9f8c269ab2a220640b
Autor:
Hendrik Ungefroren, Rüdiger Braun, Olha Lapshyna, Björn Konukiewitz, Ulrich F. Wellner, Hendrik Lehnert, Jens-Uwe Marquardt
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2640 (2022)
Pancreatic ductal adenocarcinoma (PDAC) cells are known for their high invasive/metastatic potential, which is regulated in part by the transforming growth factor β1 (TGFβ1). The involvement of at least two type I receptors, ALK5 and ALK2, that tra
Externí odkaz:
https://doaj.org/article/08893937907d4b909e6c3d7605ba1f5d
Autor:
Christin Krause, Martina Grohs, Alexander T El Gammal, Stefan Wolter, Hendrik Lehnert, Oliver Mann, Jens Mittag, Henriette Kirchner
Publikováno v:
Endocrine Connections, Vol 7, Iss 12, Pp 1448-1456 (2018)
Hepatic thyroid hormone signaling has an important role in the development and progression of nonalcoholic steatohepatitis (NASH). While the systemic levels of thyroid hormone might remain stable, there is evidence that the intracellular signaling ma
Externí odkaz:
https://doaj.org/article/6a187e65294446b197f92f7400602be1
Publikováno v:
TumorDiagnostik & Therapie. 44:189-200
Adipositas erhöht nicht nur das Risiko für Typ-2-Diabetes und Herz-Kreislauf-Komplikationen, auch Tumorerkrankungen sind eine mögliche Folge von Adipositas. Adipositas ist mit einem erhöhten Risiko assoziiert, an bestimmten Krebsarten zu erkranke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973c39d6392a07adfd6d3804836b26f2
https://doi.org/10.1055/a-1934-3145
https://doi.org/10.1055/a-1934-3145
Autor:
Dieter M. Matlac, Katerina Hadrava Vanova, Nicole Bechmann, Susan Richter, Julica Folberth, Hans K. Ghayee, Guang-Bo Ge, Luma Abunimer, Robert Wesley, Redouane Aherrahrou, Margo Dona, Ángel M. Martínez-Montes, Bruna Calsina, Maria J. Merino, Markus Schwaninger, Peter M. T. Deen, Zhengping Zhuang, Jiri Neuzil, Karel Pacak, Hendrik Lehnert, Stephanie M. J. Fliedner
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative. However, complete resection may not be an option for patients with succinate dehydrogenas
Externí odkaz:
https://doaj.org/article/341f1888ed96433699e71d363cd1e7e4
Autor:
Alessandro Di Spiezio, Elvira Sonia Sandin, Riccardo Dore, Helge Müller-Fielitz, Steffen E. Storck, Mareike Bernau, Walter Mier, Henrik Oster, Olaf Jöhren, Claus U. Pietrzik, Hendrik Lehnert, Markus Schwaninger
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 13-22 (2018)
Objective: Leptin is a key hormone in the control of appetite and body weight. Predominantly produced by white adipose tissue, it acts on the brain to inhibit homeostatic feeding and food reward. Leptin has free access to circumventricular organs, su
Externí odkaz:
https://doaj.org/article/f16f2cfd419748e59d456e48e28cc416
Autor:
Rebecca Oelkrug, Beate Herrmann, Cathleen Geissler, Lisbeth Harder, Christiane Koch, Hendrik Lehnert, Henrik Oster, Henriette Kirchner, Jens Mittag
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1126-1136 (2017)
Objective: Maternal and environmental factors control the epigenetic fetal programming of the embryo, thereby defining the susceptibility for metabolic or endocrine disorders in the offspring. Pharmacological interventions required as a consequence o
Externí odkaz:
https://doaj.org/article/1ac8db61e2f54cfbbe627e268a31c514
Autor:
Till Keller, Jes-Niels Boeckel, Stefan Groß, Jens Klotsche, Lars Palapies, David Leistner, Lars Pieper, Günnter K. Stalla, Hendrik Lehnert, Sigmund Silber, David Pittrow, Winfried Maerz, Marcus Dörr, Hans-Ulrich Wittchen, Sebastian E. Baumeister, Uwe Völker, Stephan B. Felix, Stefanie Dimmeler, Andreas M. Zeiher
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Risk stratification is crucial in prevention. Circulating microRNAs have been proposed as biomarkers in cardiovascular disease. Here a miR panel consisting of miRs related to different cardiovascular pathophysiologies, was evaluated to predi
Externí odkaz:
https://doaj.org/article/ab99906f22bc42b0ac9fff0aa4257fa7