Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Hendrik, Milting"'
Autor:
Manuel Göz, Sylvia M. Steinecker, Greta M. Pohl, Volker Walhorn, Hendrik Milting, Dario Anselmetti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract The cardiac muscle consists of individual cardiomyocytes that are mechanically linked by desmosomes. Desmosomal adhesion is mediated by densely packed and organized cadherins which, in presence of Ca2+, stretch out their extracellular domain
Externí odkaz:
https://doaj.org/article/1807c46d18be4c2ea08fbc3fbfd8671b
Autor:
Sandra Ratnavadivel, Joline Dammeier, Anna Gaertner, Marcelo A. Szymanski de Toledo, Martin Zenke, Jan Gummert, Torsten Bloch Rasmussen, Nora Klinke, Kai Jürgens, Heiko Meyer, Achim Paululat, Hendrik Milting
Publikováno v:
Stem Cell Research, Vol 76, Iss , Pp 103354- (2024)
TMEM43 (LUMA) is a ubiquitously expressed protein with unknown function. The protein is phylogenetically highly conserved and also found in Drosophila melanogaster (Klinke et al., 2022). TMEM43-p.S358L is a rare, fully penetrant mutation that leads t
Externí odkaz:
https://doaj.org/article/27366aabbbcd488c818d9ec778f6ef6a
Autor:
Józefa Dąbek, Dariusz Korzeń, Oskar Sierka, Lech Paluszkiewicz, Hendrik Milting, Zbigniew Gąsior
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 601 (2024)
The aim of the study was to assess the occurrence of classic risk factors in the study group of patients with heart failure and to link them with the transcriptional activity of the examined genes: metalloproteinase 9 (MMP-9) and the tissue inhibitor
Externí odkaz:
https://doaj.org/article/53f1551ce1304e8392d557450801f52b
Autor:
Greta Marie Pohl, Manuel Göz, Anna Gaertner, Andreas Brodehl, Tolga Cimen, Ardan M. Saguner, Eric Schulze-Bahr, Volker Walhorn, Dario Anselmetti, Hendrik Milting
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundArrhythmogenic cardiomyopathy can be caused by genetic variants in desmosomal cadherins. Since cardiac desmosomal cadherins are crucial for cell-cell-adhesion, their correct localization at the plasma membrane is essential.MethodsNine desmo
Externí odkaz:
https://doaj.org/article/9c3c4fa7f44f46cdb70eece237231b8f
Autor:
Ronja Schiemann, Annika Buhr, Eva Cordes, Stefan Walter, Jürgen J. Heinisch, Paola Ferrero, Hendrik Milting, Achim Paululat, Heiko Meyer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Muscle contraction depends on strictly controlled calcium transients within myocytes. Here, the authors show that the endopeptidase Neprilysin 4 represents an essential regulator of these transients and, consequently, of proper heart function.
Externí odkaz:
https://doaj.org/article/35c533a834ba4d80801920b2c96224dc
Autor:
Venkata Garlapati, Michael Molitor, Thomas Michna, Gregory S. Harms, Stefanie Finger, Rebecca Jung, Jeremy Lagrange, Panagiotis Efentakis, Johannes Wild, Maike Knorr, Susanne Karbach, Sabine Wild, Ksenija Vujacic-Mirski, Thomas Münzel, Andreas Daiber, Moritz Brandt, Tommaso Gori, Hendrik Milting, Stefan Tenzer, Wolfram Ruf, Philip Wenzel
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Despite major advances in acute interventions for myocardial infarction (MI), adverse cardiac remodeling and excess fibrosis after MI causing ischemic heart failure (IHF) remain a leading cause of death worldwide. Here we identify a profibrotic coagu
Externí odkaz:
https://doaj.org/article/7166825a634c4b23b74216fd69860df6
Autor:
Dena Esfandyari, Bio Maria Ghéo Idrissou, Konstantin Hennis, Petros Avramopoulos, Anne Dueck, Ibrahim El-Battrawy, Laurenz Grüter, Melanie Annemarie Meier, Anna Christina Näger, Deepak Ramanujam, Tatjana Dorn, Thomas Meitinger, Christian Hagl, Hendrik Milting, Martin Borggrefe, Stefanie Fenske, Martin Biel, Andreas Dendorfer, Yassine Sassi, Alessandra Moretti, Stefan Engelhardt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
An abnormal cardiac action potential underlies different types of cardiac arrhythmias. Here the authors show that microRNA-365 regulates the cardiac action potential by modulating key cardiac repolarizing channels.
Externí odkaz:
https://doaj.org/article/d85bf05b483c4f8fbfb7b8bb9f690c4b
Autor:
Philipp Bengel, Nataliya Dybkova, Petros Tirilomis, Shakil Ahmad, Nico Hartmann, Belal A. Mohamed, Miriam Celine Krekeler, Wiebke Maurer, Steffen Pabel, Maximilian Trum, Julian Mustroph, Jan Gummert, Hendrik Milting, Stefan Wagner, Senka Ljubojevic-Holzer, Karl Toischer, Lars S. Maier, Gerd Hasenfuss, Katrin Streckfuss-Bömeke, Samuel Sossalla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
In heart failure, increased CaMKII activity is decisively involved in arrhythmia formation. Here, the authors introduce the neuronal sodium channel NaV1.8 as a CaMKII downstream target as its specific knock-out reduces arrhythmias and improves surviv
Externí odkaz:
https://doaj.org/article/ba56cc69ae1140aebe506e2a3f9b30eb
Autor:
Dominik Sellung, Lorena Heil, Nassam Daya, Frank Jacobsen, Janine Mertens-Rill, Heidi Zhuge, Kristina Döring, Misagh Piran, Hendrik Milting, Andreas Unger, Wolfgang A. Linke, Rudi Kley, Corinna Preusse, Andreas Roos, Dieter O. Fürst, Peter F. M. van der Ven, Matthias Vorgerd
Publikováno v:
Cells, Vol 12, Iss 9, p 1321 (2023)
Myofibrillar myopathies (MFM) are a group of chronic muscle diseases pathophysiologically characterized by accumulation of protein aggregates and structural failure of muscle fibers. A subtype of MFM is caused by heterozygous mutations in the filamin
Externí odkaz:
https://doaj.org/article/20add6ba38594b8185ef55298931e823
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101276- (2022)
Summary: Recombinant SaCas9 is useful for a broad range of applications in the context of genome editing, especially when the specific protospacer adjacent motifs of other Cas9 derivatives are missing. Here, we describe a detailed protocol for the ex
Externí odkaz:
https://doaj.org/article/4c6c69c24cbd4c77aa3711e0a1a07090