Immunosuppressive effects of new thiophene-based K V 1.3 inhibitors.

Autor: Gubič Š; University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia., Montalbano A; University of Florence, Department of Experimental and Clinical Medicine, I-50134, Florence, Italy., Sala C; University of Florence, Department of Experimental and Clinical Medicine, I-50134, Florence, Italy., Becchetti A; University of Milano-Bicocca, Department of Biotechnology and Biosciences, Piazza della Scienza 2, I-20126, Milano, Italy., Hendrickx LA; University of Leuven, Toxicology and Pharmacology, Campus Gasthuisberg, Onderwijs en Navorsing 2, Herestraat 49, PO Box 922, 3000, Leuven, Belgium., Van Theemsche KM; University of Antwerp, Department of Biomedical Sciences, Campus Drie Eiken, Universiteisplein 1, 2610, Wilrijk, Belgium; Ghent University, Department of Basic and Applied Medical Sciences, Corneel Heymanslaan 10, 9000, Ghent, Belgium., Pinheiro-Junior EL; University of Leuven, Toxicology and Pharmacology, Campus Gasthuisberg, Onderwijs en Navorsing 2, Herestraat 49, PO Box 922, 3000, Leuven, Belgium., Altadonna GC; University of Siena, Department of Medical Biotechnologies, I-53100, Siena, Italy., Peigneur S; University of Leuven, Toxicology and Pharmacology, Campus Gasthuisberg, Onderwijs en Navorsing 2, Herestraat 49, PO Box 922, 3000, Leuven, Belgium., Ilaš J; University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia., Labro AJ; Ghent University, Department of Basic and Applied Medical Sciences, Corneel Heymanslaan 10, 9000, Ghent, Belgium., Pardo LA; Max-Planck Institute for Experimental Medicine, AG Oncophysiology, Hermann-Rein-Str. 3, 37075, Göttingen, Germany., Tytgat J; University of Leuven, Toxicology and Pharmacology, Campus Gasthuisberg, Onderwijs en Navorsing 2, Herestraat 49, PO Box 922, 3000, Leuven, Belgium., Tomašič T; University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia., Arcangeli A; University of Florence, Department of Experimental and Clinical Medicine, I-50134, Florence, Italy. Electronic address: annarosa.arcangeli@unifi.it., Peterlin Mašič L; University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia. Electronic address: lucija.peterlinmasic@ffa.uni-lj.si.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Nov 05; Vol. 259, pp. 115561. Date of Electronic Publication: 2023 Jun 25.

New Diarylamine K V 10.1 Inhibitors and Their Anticancer Potential.

Autor: Gubič Š; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Toplak Ž; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Shi X; AG Oncophysiology, Max-Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Göttingen, Germany., Dernovšek J; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Hendrickx LA; Toxicology and Pharmacology, Campus Gasthuisberg, University of Leuven, Onderwijs en Navorsing 2, Herestraat 49, 3000 Leuven, Belgium., Pinheiro-Junior EL; Toxicology and Pharmacology, Campus Gasthuisberg, University of Leuven, Onderwijs en Navorsing 2, Herestraat 49, 3000 Leuven, Belgium., Peigneur S; Toxicology and Pharmacology, Campus Gasthuisberg, University of Leuven, Onderwijs en Navorsing 2, Herestraat 49, 3000 Leuven, Belgium., Tytgat J; Toxicology and Pharmacology, Campus Gasthuisberg, University of Leuven, Onderwijs en Navorsing 2, Herestraat 49, 3000 Leuven, Belgium., Pardo LA; AG Oncophysiology, Max-Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Göttingen, Germany., Peterlin Mašič L; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Tomašič T; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.

Publikováno v: Pharmaceutics [Pharmaceutics] 2022 Sep 17; Vol. 14 (9). Date of Electronic Publication: 2022 Sep 17.

Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment.

Autor: Toplak Ž; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia., Hendrickx LA; Department of Toxicology and Pharmacology, University of Leuven, Leuven, Belgium., Abdelaziz R; AG Oncophysiology, Max-Planck Institute for Experimental Medicine, Göttingen, Germany., Shi X; AG Oncophysiology, Max-Planck Institute for Experimental Medicine, Göttingen, Germany., Peigneur S; Department of Toxicology and Pharmacology, University of Leuven, Leuven, Belgium., Tomašič T; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia., Tytgat J; Department of Toxicology and Pharmacology, University of Leuven, Leuven, Belgium., Peterlin-Mašič L; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia., Pardo LA; AG Oncophysiology, Max-Planck Institute for Experimental Medicine, Göttingen, Germany.

Publikováno v: Medicinal research reviews [Med Res Rev] 2022 Jan; Vol. 42 (1), pp. 183-226. Date of Electronic Publication: 2021 May 04.

3D Pharmacophore-Based Discovery of Novel K V 10.1 Inhibitors with Antiproliferative Activity.

Autor: Toplak Ž; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia., Hendrickx LA; Toxicology and Pharmacology, Campus Gasthuisberg, University of Leuven, Onderwijs en Navorsing 2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium., Gubič Š; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia., Možina Š; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia., Žegura B; Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna pot 111, 1000 Ljubljana, Slovenia.; University of Ljubljana, Kongresni trg 12, 1000 Ljubljana, Slovenia., Štern A; Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna pot 111, 1000 Ljubljana, Slovenia.; University of Ljubljana, Kongresni trg 12, 1000 Ljubljana, Slovenia., Novak M; Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna pot 111, 1000 Ljubljana, Slovenia.; University of Ljubljana, Kongresni trg 12, 1000 Ljubljana, Slovenia., Shi X; AG Oncophysiology, Max-Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Göttingen, Germany., Peigneur S; Toxicology and Pharmacology, Campus Gasthuisberg, University of Leuven, Onderwijs en Navorsing 2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium., Tytgat J; Toxicology and Pharmacology, Campus Gasthuisberg, University of Leuven, Onderwijs en Navorsing 2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium., Tomašič T; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia., Pardo LA; AG Oncophysiology, Max-Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Göttingen, Germany., Mašič LP; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia.

Publikováno v: Cancers [Cancers (Basel)] 2021 Mar 12; Vol. 13 (6). Date of Electronic Publication: 2021 Mar 12.

Design and characterization of a novel structural class of Kv1.3 inhibitors.

Autor: Hendrickx LA; University of Leuven (KUL), Toxicology and Pharmacology, Campus Gasthuisberg, Onderwijs en Navorsing 2, Herestraat 49, PO Box 922, 3000 Leuven, Belgium., Dobričić V; University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Vojvode Stepe 450, 11221 Belgrade, Serbia., Toplak Ž; University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, 1000 Ljubljana, Slovenia., Peigneur S; University of Leuven (KUL), Toxicology and Pharmacology, Campus Gasthuisberg, Onderwijs en Navorsing 2, Herestraat 49, PO Box 922, 3000 Leuven, Belgium., Mašič LP; University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, 1000 Ljubljana, Slovenia., Tomašič T; University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, 1000 Ljubljana, Slovenia., Tytgat J; University of Leuven (KUL), Toxicology and Pharmacology, Campus Gasthuisberg, Onderwijs en Navorsing 2, Herestraat 49, PO Box 922, 3000 Leuven, Belgium. Electronic address: jan.tytgat@kuleuven.be.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 May; Vol. 98, pp. 103746. Date of Electronic Publication: 2020 Mar 18.