Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19.

Autor: Dwivedi A; Trinity Kidney Centre, School of Medicine, and., Ui Mhaonaigh A; Trinity Kidney Centre, School of Medicine, and., Carroll M; Trinity Kidney Centre, School of Medicine, and., Khosravi B; Trinity Kidney Centre, School of Medicine, and., Batten I; Department of Medical Gerontology, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland., Ballantine RS; Trinity Kidney Centre, School of Medicine, and., Hendricken Phelan S; Wellcome Trust, Clinical Research Facility., O'Doherty L; Wellcome Trust, Clinical Research Facility.; Department of Infectious Diseases; and., George AM; Department of Immunology, St James's Hospital, Dublin, Ireland., Sui J; Department of Medical Gerontology, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; Department of Immunology, St James's Hospital, Dublin, Ireland., Hawerkamp HC; School of Medicine, Trinity Biomedical Sciences Institute., Fallon PG; School of Medicine, Trinity Biomedical Sciences Institute.; Department of Immunology, Trinity Translational Medicine Institute; and., Noppe E; Department of Critical Care, Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland., Mason S; Department of Critical Care, Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland., Conlon N; Department of Infectious Diseases; and.; Department of Immunology, St James's Hospital, Dublin, Ireland., Ni Cheallaigh C; Department of Infectious Diseases; and., Finlay CM; Trinity Kidney Centre, School of Medicine, and., Little MA; Trinity Kidney Centre, School of Medicine, and., Bioresource OBOTSJATTARS; The STTAR Bioresource is detailed in Supplemental Acknowledgments.

Publikováno v: JCI insight [JCI Insight] 2024 Sep 10; Vol. 9 (17). Date of Electronic Publication: 2024 Sep 10.