Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hendrick Bothmann"'
Autor:
Renza Roncarati, Silvia Papini, John Dunlop, Georg C. Terstappen, Brian Jow, Tamara Seredenina, Hendrick Bothmann, Angela Kramer, Flora Jow
Publikováno v:
ASSAY and Drug Development Technologies. 6:181-193
Heterologous functional expression of alpha7 nicotinic acetylcholine receptors (nAChRs) is difficult to achieve in mammalian cell lines, and the reasons have been associated with a lack of expression of the putative chaperone factor RIC-3. Here, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc951e024b080c0431884d00c461f7a
https://doi.org/10.1089/adt.2007.120
https://doi.org/10.1089/adt.2007.120
Autor:
John Dunlop, Hendrick Bothmann, Brian Jow, Mark R. Bowlby, Dianne Kowal, Georg C. Terstappen, Tim Lock, Renza Roncarati
Publikováno v:
Biochemical Pharmacology. 74:1172-1181
A common historical strategy to the discovery of nicotinic receptor ligands has involved the use of radioligand-binding assays for ligand identification in combination with two-electrode voltage clamp in Xenopus oocytes for electrophysiological chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c77463e4c033ae0a5842ee26a1b8577
https://doi.org/10.1016/j.bcp.2007.07.006
https://doi.org/10.1016/j.bcp.2007.07.006
Autor:
Hendrick Bothmann, Andreas Plückthun
Publikováno v:
Journal of Biological Chemistry. 275:17100-17105
The production of recombinant proteins in the periplasm of Escherichia coli can be limited by folding problems, leading to periplasmic aggregates. We used a selection system for periplasmic chaperones based on the coexpression of an E. coli library w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f441f02e98f0e93575c9bae10792e390
https://doi.org/10.1074/jbc.m910233199
https://doi.org/10.1074/jbc.m910233199
Autor:
Hendrick Bothmann, Andreas Plückthun
Publikováno v:
Nature Biotechnology. 16:376-380
The efficiency of both phage display in Escherichia coli and periplasmic expression of recombinant proteins may be limited by the same periplasmic folding steps. To search for E. coli factors that improve the efficiency of both procedures, a library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c779dbaed5f69d0f4619243056d933d7
https://doi.org/10.1038/nbt0498-376
https://doi.org/10.1038/nbt0498-376
Autor:
Dianne Kowal, Ugo Zanelli, Riccardo Zanaletti, Laura Maccari, Maurizio Varrone, Albert J. Robichaud, Tim Lock, Michela Valacchi, Renza Roncarati, Carla Scali, Li Di, Georg C. Terstappen, Iolanda Micco, Flora Jow, Cristiana Castaldo, Arianna Nencini, Angela Kramer, Thomas A. Comery, John Dunlop, Suzan Aschmies, Hendrick Bothmann, Karen L. Marquis, Elisa Turlizzi, Chiara Ghiron, Giuseppe Cocconcelli, Salvatore La Rosa, Simon Haydar, Boyd L. Harrison, Joanna Quinn, Steven M. Grauer
Publikováno v:
Journal of medicinal chemistry. 53(11)
Alpha-7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment. We report a series of novel, potent small molecule agonists (4-18) of the alpha7 nAChR deriving from our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e335cbea368c3d67bdfa12e50c49f4
https://pubmed.ncbi.nlm.nih.gov/20465311
https://pubmed.ncbi.nlm.nih.gov/20465311
Autor:
Maurizio Varrone, Laura Bettinetti, Carla Scali, Renza Roncarati, Martina Pollastrini, Hendrick Bothmann, Riccardo Zanaletti, John Dunlop, Chiara Ghiron, Salvatore La Rosa, Iolanda Micco, Thomas A. Comery, Simon Haydar, Joanna Quinn, Michela Valacchi
Publikováno v:
Bioorganicmedicinal chemistry. 17(14)
Alpha 7 nicotinic acetylcholine receptor (alpha(7) nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment associated with a variety of disorders including Alzheimer's disease and schizophrenia. Alpha 7 nAChRs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4150060883ac627578b23e37757bc5f
https://pubmed.ncbi.nlm.nih.gov/19515567
https://pubmed.ncbi.nlm.nih.gov/19515567
Autor:
Georg C. Terstappen, Thomas A. Comery, Suzan Aschmi, Hendrick Bothmann, Carla Scali, Renza Roncarati, Steven M. Grauer, Brian Jow, Dianne Kowal, Ugo Zanelli, Marco Gianfriddo, Chiara Ghiron, Cody Kelley, John Dunlop, Simon Haydar
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 329(2)
The alpha7 nicotinic acetylcholine receptor (nAChR) is a promising target for treatment of cognitive dysfunction associated with Alzheimer's disease and schizophrenia. Here, we report the pharmacological properties of 5-morpholin-4-yl-pentanoic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbb0cce09cce33e00f4f1415b25eb68
https://pubmed.ncbi.nlm.nih.gov/19223665
https://pubmed.ncbi.nlm.nih.gov/19223665
Autor:
Silvia Papini, Arianna Nencini, Iolanda Micco, Chiara Ghiron, Alessandro Padova, Joanna Quinn, Hendrick Bothmann
Publikováno v:
Bioorganicmedicinal chemistry. 16(5)
Alpha7 agonists were identified via GOLD (CCDC) docking in the putative agonist binding site of an alpha7 homology model and a series of aminoalkyl benzoimidazoles was synthesised to obtain potentially brain penetrant drugs. The array was prepared st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196bff4063b62649b9cfa8c222125f16
https://pubmed.ncbi.nlm.nih.gov/18078760
https://pubmed.ncbi.nlm.nih.gov/18078760
Autor:
Christian M. Apfel, Hendrick Bothmann, Arnulf Dorn, Andreas Ebneth, Francis Hermann, Gerhard Trube, Klaus Christensen
Publikováno v:
Journal of biomolecular screening. 10(4)
The number of projects in drug development that fail in late phases because of cardiac side effects such as QT prolongation can impede drug discovery and development of projects. The molecular target responsible for QT prolongation by a wide range of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe45e8cf59b4c7d3f0c4e38ba6976142
https://pubmed.ncbi.nlm.nih.gov/15964935
https://pubmed.ncbi.nlm.nih.gov/15964935
Autor:
Cody Kelley, Renza Roncarati, Simon Haydar, Georg C. Terstappen, Marco Gianfriddo, Steven M. Grauer, Suzan Aschmies, John Dunlop, Hendrick Bothmann, Radka Graf, Brian Jow, Thomas A. Comery, Carla Scali, Chiara Ghiron
Publikováno v:
Schizophrenia Research. 102:262
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42bf3576d8ea79e212b8f4363f90c4d9
https://doi.org/10.1016/s0920-9964(08)70790-4
https://doi.org/10.1016/s0920-9964(08)70790-4