Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hend M. Abdelghany"'
Autor:
Rasha F Ahmed, Olfat Gamil Shaker, Hend M abdelghany, Nilly Helmy Abdallah, Samar Hisham Elsayed, Bothina Ahmed Kamel
Publikováno v:
Lupus. 31:89-96
Background The skin and the kidney are commonly affected in systemic lupus erythematosus (SLE) with similar molecular mechanisms. Although clinical indicators of renal injury in SLE are fairly uncontroversial, few biomarkers are reliable. The role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0f5d9bdf2f3b178648087502e8aef4
https://doi.org/10.1177/09612033211067166
https://doi.org/10.1177/09612033211067166
Publikováno v:
IUBMB life. 70(6)
Liver fibrosis is an excessively reversible wound healing process and the fibrotic disorder is the activation of hepatic stellate cell that requires extensive alterations in gene expression. As reversible deacetylation of histone proteins modulate ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd6150c073e550f20dadc8b6d3026557
https://pubmed.ncbi.nlm.nih.gov/29601129
https://pubmed.ncbi.nlm.nih.gov/29601129
Autor:
Scott Bailey, Hend M. Abdelghany, Alexander G. McLennan, John B. Rafferty, G. Michael Blackburn
Publikováno v:
Journal of Biological Chemistry. 278:4435-4439
The contributions to substrate binding and catalysis of 13 amino acid residues of the Caenorhabditis elegans diadenosine tetraphosphate pyrophosphohydrolase (Ap(4)A hydrolase) predicted from the crystal structure of an enzyme-inhibitor complex have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b19cf2e5399b0f88f7b0eafff716436
https://doi.org/10.1074/jbc.m211983200
https://doi.org/10.1074/jbc.m211983200
Autor:
Scott Bailey, Alexander G. McLennan, Lakhdar Gasmi, John B. Rafferty, Hend M. Abdelghany, Jared L. Cartwright
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1550:27-36
Asymmetrically cleaving diadenosine 5',5"'-P(1),P(4)-tetraphosphate (Ap4A) hydrolase activity has been detected in extracts of adult Caenorhabditis elegans and the corresponding cDNA amplified and expressed in Escherichia coli. As expected, sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3387861d54839b61f13dede2121ba6a9
https://doi.org/10.1016/s0167-4838(01)00263-1
https://doi.org/10.1016/s0167-4838(01)00263-1
Autor:
Svetlana E. Sedelnikova, Alexander G. McLennan, John B. Rafferty, Hend M. Abdelghany, Scott Bailey, G. Michael Blackburn
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 58:526-528
The molecule diadenosine tetraphosphate (Ap(4)A) has been suggested to be a component of the cellular response to metabolic stress and/or, via the intracellular Ap(3)A/Ap(4)A ratio, to be involved in differentiation and apoptosis. Thus, the enzyme Ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de74bea31ae962fe9ba8f34d5017bdae
https://doi.org/10.1107/s0907444902000768
https://doi.org/10.1107/s0907444902000768
Autor:
Scott Bailey, Svetlana E. Sedelnikova, Alexander G. McLennan, Hend M. Abdelghany, G. Michael Blackburn, Patrick J. Baker, John B. Rafferty
Publikováno v:
Structure (London, England : 1993). 10(4)
The crystal structure of C. elegans Ap 4 A hydrolase has been determined for the free enzyme and a binary complex at 2.0 A and 1.8 A, respectively. Ap 4 A hydrolase has a key role in regulating the intracellular Ap 4 A levels and hence potentially th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3085d3335610b656549eabba948f7853
https://pubmed.ncbi.nlm.nih.gov/11937063
https://pubmed.ncbi.nlm.nih.gov/11937063