Zobrazeno 1 - 10
of 956
pro vyhledávání: '"Hemogenic endothelium"'
Publikováno v:
Медицинская иммунология, Vol 26, Iss 5, Pp 883-890 (2024)
The generation of immune cell populations from induced pluripotent stem cells (iPSCs) is a valuable model to study mechanisms that control hematopoietic development; it also is a promising approach to develop immunotherapeutic strategies to treat var
Externí odkaz:
https://doaj.org/article/69368d267fe84b8a9d7de380c905c4a6
Publikováno v:
eLife, Vol 12 (2024)
Hematopoietic stem cells emerge in the embryo from an aortic-derived tissue called the hemogenic endothelium (HE). The HE appears to give birth to cells of different nature and fate but the molecular principles underlying this complexity are largely
Externí odkaz:
https://doaj.org/article/fd7ce616d0cb4074981be2686f519a9c
Autor:
Pankaj Sahai-Hernandez, Claire Pouget, Shai Eyal, Ondrej Svoboda, Jose Chacon, Lin Grimm, Tor Gjøen, David Traver
Publikováno v:
eLife, Vol 12 (2023)
Development of the dorsal aorta is a key step in the establishment of the adult blood-forming system, since hematopoietic stem and progenitor cells (HSPCs) arise from ventral aortic endothelium in all vertebrate animals studied. Work in zebrafish has
Externí odkaz:
https://doaj.org/article/bbaa00beae7c476f9a0d6cf3c8cc9b43
Akademický článek
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Autor:
Ning Wang, Chuxin Chen, Yang Cheng, Yingjie Fu, Zhiyong Zhong, Yu Yang, Ling Lv, Honglin Chen, Jian Huang, Yuyou Duan
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-20 (2022)
Abstract Background Hematopoietic stem cells are able to self-renew and differentiate into all blood cell lineages. Hematopoietic stem cell transplantation is a mainstay of life-saving therapy for hematopoietic malignancies and hypoproliferative diso
Externí odkaz:
https://doaj.org/article/3eab7c64841145009a93105a014d1474
Autor:
Alejandra Vargas-Valderrama, Anne-Charlotte Ponsen, Morgane Le Gall, Denis Clay, Sébastien Jacques, Tudor Manoliu, Valérie Rouffiac, Karine Ser-le-Roux, Cyril Quivoron, Fawzia Louache, Georges Uzan, Maria-Teresa Mitjavila-Garcia, Estelle Oberlin, Hind Guenou
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-24 (2022)
Abstract Background hPSC-derived endothelial and hematopoietic cells (ECs and HCs) are an interesting source of cells for tissue engineering. Despite their close spatial and temporal embryonic development, current hPSC differentiation protocols are s
Externí odkaz:
https://doaj.org/article/5bcde842d3c945a4ac8d6055995870f9
Autor:
Shailendra Maurya, Wei Yang, Minori Tamai, Qiang Zhang, Petra Erdmann-Gilmore, Amelia Bystry, Fernanda Martins Rodrigues, Mark C. Valentine, Wing H Wong, Reid Townsend, Todd E. Druley
Publikováno v:
Epigenetics, Vol 17, Iss 2, Pp 220-238 (2022)
Germline or somatic variation in the family of KMT2 lysine methyltransferases have been associated with a variety of congenital disorders and cancers. Notably, KMT2A-fusions are prevalent in 70% of infant leukaemias but fail to phenocopy short latenc
Externí odkaz:
https://doaj.org/article/a58160069304439ba8850cc6a46f742f
Publikováno v:
Stem Cell Research, Vol 62, Iss , Pp 102808- (2022)
To achieve efficient, reproducible differentiation of human pluripotent stem cells (hPSCs) towards specific hematopoietic cell-types, a comprehensive understanding of the necessary cell signaling and developmental trajectories involved is required. P
Externí odkaz:
https://doaj.org/article/c4fb56483b48417cafff9d9309fc9992
Autor:
Anna Klaus, Thomas Clapes, Laurent Yvernogeau, Sreya Basu, Bart Weijts, Joris Maas, Ihor Smal, Niels Galjart, Catherine Robin
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110957- (2022)
Summary: Hematopoietic stem cells (HSCs) express a large variety of cell surface receptors that are associated with acquisition of self-renewal and multipotent properties. Correct expression of these receptors depends on a delicate balance between ce
Externí odkaz:
https://doaj.org/article/b4488eee3f6c4c19b6336b0c4501bb66
Autor:
Serge A. van de Pavert
Publikováno v:
Biomedical Journal, Vol 44, Iss 2, Pp 123-132 (2021)
Innate Lymphoid Cells (ILC) are involved in homeostasis and immunity. Their dynamic differentiation and characterization depend on their tissue of residency and is adapted to their role within these tissues. Lymphoid Tissue inducer (LTi) cells are an
Externí odkaz:
https://doaj.org/article/34977e4e7b864035b6f66de17f15e356