MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy

Autor: Guido Moll, Norman Drzeniek, Julian Kamhieh-Milz, Sven Geissler, Hans-Dieter Volk, Petra Reinke

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Numerous clinical trials of mesenchymal stromal/stem cells (MSCs) as a new treatment for coronavirus-induced disease (COVID-19) have been registered recently, most of them based on intravenous (IV) infusion. There is no approved effective therapy for

Externí odkaz: https://doaj.org/article/0a2158a860374bd0bd3c1edd8d051994

The optimal incubation time for in vitro hemocompatibility testing

Autor: Gerwin E. Engels, Sjoerd Leendert Johannes Blok, Willem van Oeveren

Publikováno v: Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 107(7), 2335-2342. Wiley-Blackwell
Journal of Biomedical Materials Research. Part B, Applied Biomaterials

During hemocompatibility testing, activation products may reach plateau values which can result in less distinction between hemocompatible and hemo-incompatible materials. Of concern is an underestimation of the blood activation caused by the biomate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c4db565be95203b3ecae2c6e2fa333
https://research.rug.nl/en/publications/7ea23481-0431-4217-83f5-a018021d11c3

Downsizing of a Pulsatile Total Artificial Heart-The Effect on Hemolysis

Autor: Mario Diedrich, Sebastian V. Jansen, Heiko De Ben, Marvin Lowes, Moritz K Brockhaus, Thomas Schmitz-Rode, Stephan Hildebrand, Ulrich Steinseifer

Publikováno v: ASAIO journal (American Society for Artificial Internal Organs : 1992). 68(1)

A downsized version of the ReinHeart total artificial heart (TAH) was developed. Hemocompatibility needs to be revised since the operating point of the downsized TAH has changed to a higher pump frequency to accomplish the same cardiac output. A mock

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7d393d53033e17ec40af531238a980
https://pubmed.ncbi.nlm.nih.gov/33769348

Bioconjugation of a Collagen-Mimicking Peptide Onto Poly(vinyl alcohol) Encourages Endothelialization While Minimizing Thrombosis

Autor: Novella M Bates, Monica T. Hinds, Meghan E. Fallon, Evelyn K.F. Yim, Deirdre E.J. Anderson, Heather E Heidenreich, Yuan Yao

Publikováno v: Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)

Poly(vinyl alcohol) hydrogel, PVA, is a suitable material for small-diameter vascular grafting. However, the bioinert properties of the material do not allow for in situ endothelialization, which is needed to combat common graft failure mechanisms, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcac5fc924f7d908aa41061a07ec9db
https://pubmed.ncbi.nlm.nih.gov/33425883

In Vitro Hemocompatibility Evaluation of Ventricular Assist Devices in Pediatric Flow Conditions: A Benchmark Study

Autor: Luiz C. Sampaio, Charles D. Fraser, Jun Teruya, Chris H H Chan, Kayla Moody, Sara Diab, O. Howard Frazier, Iki Adachi

Publikováno v: Artificial Organs. 42:1028-1034

Development of pediatric ventricular assist devices (VADs) has significantly lagged behind that of adult devices. This frustrating reality is reflected by the fact that the Berlin Heart EXCOR VAD is currently the only approved pediatric-specific devi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9caecf37bd57eb1d81ba53743ee4fd6e
https://doi.org/10.1111/aor.13165