Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hemma Schueffl"'
Autor:
Valeriya Gushchina, Nadja Kupper, Michael Schwarzkopf, Gitta Frisch, Karina Piatek, Cornelia Aigner, Alexandra Michel, Hemma Schueffl, Luca Iamartino, Taha Elajnaf, Teresa Manhardt, Andrea Vlasaty, Petra Heffeter, Marcella Bassetto, Enikö Kállay, Martin Schepelmann
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The prostaglandin E2 (PGE2) pathway is one of the main mediators of intestinal inflammation. As activation of the calcium-sensing receptor (CaSR) induces expression of inflammatory markers in the colon, we assessed the impact of the CaS
Externí odkaz:
https://doaj.org/article/bfae8753d1d3454c835375973e899db4
Autor:
Magdalena Billerhart, Monika Schönhofer, Hemma Schueffl, Wolfram Polzer, Julia Pichler, Simon Decker, Alexander Taschauer, Julia Maier, Martina Anton, Sebastian Eckmann, Manuel Blaschek, Petra Heffeter, Haider Sami, Manfred Ogris
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 192-204 (2021)
CD47 protects healthy cells from macrophage attack by binding to signal regulatory protein α (SIRPα), while its upregulation in cancer prevents immune clearance. Systemic treatment with CD47 antibodies requires a weakened Fc-mediated effector funct
Externí odkaz:
https://doaj.org/article/fbc76bda15084da5b486c7e7f8991b05
Autor:
Theresa Mendrina, Isabella Poetsch, Hemma Schueffl, Dina Baier, Christine Pirker, Alexander Ries, Bernhard K. Keppler, Christian R. Kowol, Dan Gibson, Michael Grusch, Walter Berger, Petra Heffeter
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 677 (2023)
For a variety of cancer types, platinum compounds are still among the best treatment options. However, their application is limited by side effects and drug resistance. Consequently, multi-targeted platinum(IV) prodrugs that target specific traits of
Externí odkaz:
https://doaj.org/article/d102ca7b6f4249b589624b681c2fe80d
Autor:
Eva Mittermair, Hanspeter Kählig, Ammar Tahir, Stefanie Rindler, Xenia Hudec, Hemma Schueffl, Petra Heffeter, Brigitte Marian, Liselotte Krenn
Publikováno v:
Molecules, Vol 25, Iss 19, p 4449 (2020)
The tree fern Metaxya rostrata (Kunth) C. Presl is common in the rainforests of Central and South America, where suspensions of the dried rhizome are traditionally used to treat intestinal diseases. Two compounds from this plant, 2-deprenyl-rheediaxa
Externí odkaz:
https://doaj.org/article/8f05f046c3644d25a27b7a1ccf14c631
Publikováno v:
Targeted Metallo-Drugs ISBN: 9781003272250
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7cab4fad7344c83091b08784f64284f
https://doi.org/10.1201/9781003272250-1
https://doi.org/10.1201/9781003272250-1
Autor:
Tomer Babu, Hiba Ghareeb, Uttara Basu, Hemma Schueffl, Sarah Theiner, Petra Heffeter, Gunda Koellensperger, Norman Metanis, Valentina Gandin, Ingo Ott, Claudia Schmidt, Dan Gibson
Publikováno v:
Angewandte Chemie. 135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805c9e38e533165ab2b182cc99d5dcc9
https://doi.org/10.1002/ange.202217233
https://doi.org/10.1002/ange.202217233
Autor:
Sebastian Eckmann, Martina Anton, Julia Pichler, Manfred Ogris, Simon Decker, Wolfram Polzer, Hemma Schueffl, Julia Maier, Magdalena Billerhart, Petra Heffeter, Monika Schönhofer, Manuel Blaschek, Alexander Taschauer, Haider Sami
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 23, Iss, Pp 192-204 (2021)
Molecular Therapy: Oncolytics, Vol 23, Iss, Pp 192-204 (2021)
CD47 protects healthy cells from macrophage attack by binding to signal regulatory protein α (SIRPα), while its upregulation in cancer prevents immune clearance. Systemic treatment with CD47 antibodies requires a weakened Fc-mediated effector funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e1106e4f3903bcbd70d2572079db48
http://europepmc.org/articles/PMC8526499
http://europepmc.org/articles/PMC8526499
Autor:
Enrico Falcone, Alessandra G. Ritacca, Sonja Hager, Hemma Schueffl, Bertrand Vileno, Youssef El Khoury, Petra Hellwig, Christian R. Kowol, Petra Heffeter, Emilia Sicilia, Peter Faller
Publikováno v:
Journal of the American Chemical Society. 144(32)
Glutathione (GSH) is the most abundant thiol in mammalian cells and plays a crucial role in maintaining redox cellular homeostasis. The thiols of two GSH molecules can be oxidized to the disulfide GSSG. The cytosolic GSH/GSSG ratio is very high (100)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126a592cc81eacc9ff416dbfbacd05cf
https://pubmed.ncbi.nlm.nih.gov/35929814
https://pubmed.ncbi.nlm.nih.gov/35929814
Autor:
Éva A. Enyedy, Bernhard K. Keppler, Christian R. Kowol, Orsolya Dömötör, Petra Heffeter, Marlene Mathuber, Hemma Schueffl, Claudia Karnthaler
Publikováno v:
Inorganic Chemistry
Although tyrosine kinase inhibitors (TKIs) have revolutionized cancer therapy in the past two decades, severe drawbacks such as strong adverse effects and drug resistance limit their clinical application. Prodrugs represent a valuable approach to ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d7738f88bdddbbe581e488ee4fd366
https://doi.org/10.1021/acs.inorgchem.0c03083
https://doi.org/10.1021/acs.inorgchem.0c03083
Publikováno v:
Planta Medica. 86:1073-1079
We recently isolated the prenylated xanthones 2-deprenyl-rheediaxanthone B (XB) and 2-deprenyl-7-hydroxy-rheediaxanthone B (OH-XB) from the South American tree fern Metaxya rostrata. This study explores the mechanisms underlying the FoxM1 downregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399f97282abb68c38a43a409ff3cb0cb
https://doi.org/10.1055/a-1097-8722
https://doi.org/10.1055/a-1097-8722