Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Hemlata Varsani"'
Autor:
Yvonne Vercoulen, Felicitas Bellutti Enders, Jenny Meerding, Maud Plantinga, Elisabeth F Elst, Hemlata Varsani, Christa van Schieveen, Mette H Bakker, Mark Klein, Rianne C Scholman, Wim Spliet, Valeria Ricotti, Hans J P M Koenen, Roel A de Weger, Lucy R Wedderburn, Annet van Royen-Kerkhof, Berent J Prakken
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105353 (2014)
Juvenile dermatomyositis (JDM) is an immune-mediated inflammatory disease affecting the microvasculature of skin and muscle. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are key regulators of immune homeostasis. A role for Tregs in JDM pathogenesis h
Externí odkaz:
https://doaj.org/article/3296525a23284cd694bfd5b6d58efaec
Autor:
F W, Miller, W, Chen, T P, O'Hanlon, R G, Cooper, J, Vencovsky, L G, Rider, K, Danko, L R, Wedderburn, I E, Lundberg, L M, Pachman, A M, Reed, S R, Ytterberg, L, Padyukov, A, Selva-O'Callaghan, T R, Radstake, D A, Isenberg, H, Chinoy, W E R, Ollier, P, Scheet, B, Peng, A, Lee, J, Byun, J A, Lamb, P K, Gregersen, C I, Amos, Hemlata, Varsani
Publikováno v:
Genes & Immunity. 16:470-480
Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors in patients of European ancestry, we conducted a genome-wide association study (GWAS) of th
Autor:
Wei V. Chen, Lisa G. Rider, Robert G. Cooper, Ann M. Reed, Jiří Vencovský, Janine A. Lamb, Mark F. Gourley, Timothy R D J Radstake, David Hilton-Jones, William E R Ollier, Steven R. Ytterberg, Albert Selva-O'Callaghan, Paul H. Plotz, Peter K. Gregersen, David A. Isenberg, Ingrid E. Lundberg, Bo Peng, Terrance P. O'Hanlon, Patrick Kiely, Christopher P. Denton, Katalin Dankó, Paul Scheet, Frederick W. Miller, Hector Chinoy, Annette Lee, Lauren M. Pachman, Lucy R. Wedderburn, Leonid Padyukov, Hemlata Varsani, Christopher I. Amos
Publikováno v:
Arthritis & Rheumatism. 65:3239-3247
Objective. To identify new genetic associations with juvenile and adult dermatomyositis (DM). Methods. We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1178) and controls (n = 4724). To a
Autor:
Caroline Sewry, Lucy R. Wedderburn, Frances Hall, Sisa Grubnic, Susan C. Charman, Brenda Banwell, Alexandra M. Higton, Tilly Ratnaike, Eleni Sidiropoulou, Anthony A. Amato, Robert Busch, Felix Chua, Thomas S. Jacques, Ingrid E. Lundberg, Nicola Maguire, Carlo Minetti, Clive Kelly, Loukas Settas, Nicholas Hughes, Nada Hassan, Hemlata Varsani, Nazar Alsanjari, Janice L. Holton, Matthew Rogers, Vasiliki Tsavdaridou, Philippa A. Watson, Andrea M. Corse, Nagui Gendi, Inger Nenesmo, Susan Pugmire, Elisabeth J. Rushing, Patrick D W Kiely, Timothy Ho, M Field, Kevin E. Bove, Zoe McKinstry, Katrina McNulty, Clarissa Pilkington, Elizabeth J. Edwards, Brian Fang, Vadivelu Saravanan, Eleanor Murray, David A. Isenberg, Ana Campar, Andreas V. Hadjinicolaou, Ioannides Vlahos, Theodoros Dimitroulas, Martin Edward Perry, Suely Marie, Carolyn Lavelle, Alison Emslie-Smith, David Paton, Mark Lloyd
Publikováno v:
Rheumatology. 49:i115-i119
Autor:
Sonia Shah, Paul Knopp, Bhanu P. Singh, Halima Moncrieffe, Charles K. Li, Bin Gao, Lucy R. Wedderburn, Kanneboyina Nagaraju, Hemlata Varsani
Publikováno v:
The American Journal of Pathology. 175:1030-1040
Folding and transport of proteins, such as major histocompatibility complex (MHC) class I, through the endoplasmic reticulum (ER) is tightly regulated in all cells, including muscle tissue, where the specialized ER sarcoplasmic reticulum is also crit
Autor:
Hemlata Varsani, Kiran Nistala, Katy Newton, Halima Moncrieffe, Patricia Hunter, Lucy R. Wedderburn
Publikováno v:
Arthritis and Rheumatism
Objective To identify interleukin-17 (IL-17)–producing T cells from patients with juvenile idiopathic arthritis (JIA), and investigate their cytokine production, migratory capacity, and relationship to Treg cells at sites of inflammation, as well a
Autor:
Stephanie Simou, Neil McHugh, Peter W. Schutz, Lucy R. Wedderburn, Sarah L Tansley, Claire T Deakin, Thomas S. Jacques, Hemlata Varsani, Janice L. Holton, Erdal Sag, SA Yasin
Publikováno v:
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 44:S6-S6
Autor:
Hemlata Varsani, Lucy R. Wedderburn, Katie Arnold, Kiran Nistala, Claudia Mauri, David Bending, Christopher Piper
Publikováno v:
Pediatric Rheumatology Online Journal
Juvenile dermatomyositis (JDM) is a childhood autoimmune disease characterised by proximal muscle weakness and cutaneous manifestations. Previous studies have identified an increase in circulating B cells in JDM patients, but their provenance and fun
Autor:
P Woo, David C. Linch, Rachel Jeffery, Anand Patel, Hemlata Varsani, Lucy R. Wedderburn, Harry N White, K. J. Murray
Publikováno v:
Rheumatology. 40:1299-1307
We have studied immune reconstitution in a patient with paediatric-onset polyarteritis nodosa treated with high-dose immunosuppressive agents followed by stem cell rescue. The patient developed several new autoimmune phenomena over the 18 months afte
Publikováno v:
Immunology. 102:301-309
While the T-cell receptor (TCR) repertoire of the newborn is highly diverse, a gradual alteration in diversity of the expressed TCR repertoire, in particular the oligoclonality of CD8+ T cells, occurs with increasing age. The timing of the initiation