Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma.

Autor: Frontzek F; Department of Medicine A, Department of Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Staiger AM; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Tübingen, Germany.; Department of Clinical Pathology, Robert Bosch Hospital, Stuttgart, Germany., Zapukhlyak M; Department of Medicine A, Department of Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Xu W; Department of Medicine A, Department of Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Bonzheim I; Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen-Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany., Borgmann V; Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen-Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany., Sander P; Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen-Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany., Baptista MJ; Department of Hematology, ICO-Hospital Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute (IJC), Universitat Autònoma de Barcelona, Badalona, Spain., Heming JN; Department of Medicine A, Department of Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Berning P; Department of Medicine A, Department of Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Wullenkord R; Department of Medicine A, Department of Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Erdmann T; Department of Medicine A, Department of Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Lutz M; Department of Medicine A, Department of Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Veratti P; Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany., Ehrenfeld S; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Wienand K; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany., Horn H; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Tübingen, Germany.; Department of Clinical Pathology, Robert Bosch Hospital, Stuttgart, Germany., Goodlad JR; Department of Pathology, Queen Elizabeth University Hospital, Glasgow, United Kingdom., Wilson MR; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Anagnostopoulos I; Institute of Pathology, University of Würzburg, Würzburg, Germany.; Charité Comprehensive Cancer Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany., Lamping M; Charité Comprehensive Cancer Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany., Gonzalez-Barca E; Department of Hematology. ICO-Hospital Duran i Reynals, Universitat de Barcelona, L'Hospitalet de Llobregat, Llobregat, Spain., Climent F; Department of Pathology. Hospital Universitari de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Llobregat, Spain., Salar A; Department of Hematology, Hospital del Mar, Barcelona, Spain., Castellvi J; Department of Pathology, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Abrisqueta P; Department of Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Menarguez J; Department of Pathology, Hospital Gregorio Marañón, Madrid, Spain., Aldamiz T; Department of Infectious Diseases, Hospital Gregorio Marañón, Madrid, Spain., Richter J; Division of Hematophathology, Christian-Albrechts-University, Kiel, Germany., Klapper W; Division of Hematophathology, Christian-Albrechts-University, Kiel, Germany., Tzankov A; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Dirnhofer S; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Rosenwald A; Institute of Pathology, University of Würzburg, Würzburg, Germany., Mate JL; Department of Pathology, Hospital Germans Trias i Pujol, Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona, Badalona, Spain., Tapia G; Department of Pathology, Hospital Germans Trias i Pujol, Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona, Badalona, Spain., Lenz P; Department of Physics, University of Marburg, Marburg, Germany., Miething C; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Hartmann W; Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany., Chapuy B; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany., Fend F; Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen-Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany., Ott G; Department of Clinical Pathology, Robert Bosch Hospital, Stuttgart, Germany., Navarro JT; Department of Hematology, ICO-Hospital Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute (IJC), Universitat Autònoma de Barcelona, Badalona, Spain., Grau M; Department of Medicine A, Department of Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Lenz G; Department of Medicine A, Department of Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany. Georg.Lenz@ukmuenster.de.

Publikováno v: Nature communications [Nat Commun] 2021 Aug 31; Vol. 12 (1), pp. 5183. Date of Electronic Publication: 2021 Aug 31.