Utilization of In Vitro, In Vivo and In Silico Tools to Evaluate the pH-Dependent Absorption of a BCS Class II Compound and Identify a pH-Effect Mitigating Strategy.

Autor: Gesenberg C; Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey, USA. christoph.gesenberg@bms.com.; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey, USA. christoph.gesenberg@bms.com., Mathias NR; Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey, USA., Xu Y; Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey, USA.; Quantitative Clinical Pharmacology, Acerta Pharma, LLC, A Member of the AstraZeneca Group, South San Francisco, California, USA., Crison J; Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey, USA., Savant I; Clinical Pharmacology, Bristol-Myers Squibb Company, Princeton, New Jersey, USA.; Clinical Pharmacology and Translational Medicine, Eisai Inc., Woodcliff Lake, New Jersey, USA., Saari A; Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey, USA.; Drug Safety Evaluation, Bristol-Myers Squibb Company, New Brunswick, New Jersey, USA., Good DJ; Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey, USA., Hemenway JN; Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey, USA.; Formulation and Process Development, Gilead Sciences, Inc., Foster City, California, USA., Narang AS; Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey, USA.; Small Molecule Pharmaceutical Sciences, Genentech, Inc., South San Francisco, California, USA., Schartman RR; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut, USA.; PreFormulation Solutions, Wallingford, Connecticut, USA., Zheng N; Bioanalytical Sciences, Bristol-Myers Squibb Company, Princeton, New Jersey, USA., Buzescu A; Bioanalytical Sciences, Bristol-Myers Squibb Company, Princeton, New Jersey, USA., Patel J; Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey, USA.; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA.

Publikováno v: Pharmaceutical research [Pharm Res] 2019 Oct 21; Vol. 36 (12), pp. 164. Date of Electronic Publication: 2019 Oct 21.

In vitro and in vivo evaluation of a novel water-soluble N-glycyl prodrug (N-GLY-CBZ) of carbamazepine.

Autor: Hemenway JN; Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA., Stella VJ

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2010 Nov; Vol. 99 (11), pp. 4565-75.

Preparation, characterization and in vivo conversion of new water-soluble sulfenamide prodrugs of carbamazepine.

Autor: Hemenway JN; Department of Pharmaceutical Chemistry, 2095 Constant Avenue, University of Kansas, Lawrence, KS 66047, USA., Nti-Addae K, Guarino VR, Stella VJ

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Dec 01; Vol. 17 (23), pp. 6629-32. Date of Electronic Publication: 2007 Sep 15.