Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Heme export"'
Publikováno v:
mLife, Vol 3, Iss 3, Pp 327-342 (2024)
Abstract Heme is an important cofactor and a regulatory molecule involved in various physiological processes in virtually all living cellular organisms, and it can also serve as the primary iron source for many bacteria, particularly pathogens. Howev
Externí odkaz:
https://doaj.org/article/2bc110128af141968a5fb46d2243a0d8
Autor:
Giovanna De Simone, Romualdo Varricchio, Tommaso Francesco Ruberto, Alessandra di Masi, Paolo Ascenzi
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 575 (2023)
Heme is the reactive center of several metal-based proteins that are involved in multiple biological processes. However, free heme, defined as the labile heme pool, has toxic properties that are derived from its hydrophobic nature and the Fe-atom. Th
Externí odkaz:
https://doaj.org/article/1b9da3e5726a405a8c9f0f011241cc63
Akademický článek
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Autor:
Megan E Tucker, Rusty A. Gonser, Veronica Fiorito, Kyra Firestone, Fiorella Altruda, Deborah Chiabrando, Joseph H. Hersh, Alexander Asamoah, Emanuela Tolosano, Francesca Bertino, Kelly E. Jackson, Emanuele Bellacchio, Francesca Destefanis
Publikováno v:
Pain. 160:2766-2775
Hereditary sensory and autonomic neuropathies (HSANs) are a group of clinically and genetically heterogeneous disorders of the peripheral nervous system mainly characterized by impaired nociception and autonomic dysfunction. We previously identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23900d881fbb30df6b2753354df4e0a2
https://doi.org/10.1097/j.pain.0000000000001675
https://doi.org/10.1097/j.pain.0000000000001675
Autor:
Silvia Deaglio, S. Torretta, Nazzareno Capitanio, Carlotta Cancelliere, Emanuela Tolosano, Enzo Medico, Alberto Bardelli, Francesca Destefanis, Anna Lucia Allocco, Veronica Fiorito, Consiglia Pacelli, Paolo Pinton, Livio Trusolino, Elena Gazzano, Fiorella Altruda, Deborah Chiabrando, Sara Petrillo, Paolo Provero, Saverio Marchi, S. Cardaci, Valentina Audrito, Chiara Riganti, Paolo E. Porporato
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109252-(2021)
Summary Heme is an iron-containing porphyrin of vital importance for cell energetic metabolism. High rates of heme synthesis are commonly observed in proliferating cells. Moreover, the cell-surface heme exporter feline leukemia virus subgroup C recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd5eeb98212722901ee7f2ed8574263
https://hdl.handle.net/11392/2497991
https://hdl.handle.net/11392/2497991
Bacterial growth and survival critically hinges on the ability to rapidly adapt to ever-changing environmental conditions. Elaborated stress response systems allow bacteria to sensitively detect and adequately respond to fluctuations in environmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e63dd3b044c7d48833bf15e81187ac
Autor:
Federico Mussano, Giorgio R. Merlo, Emanuela Tolosano, Tullio Genova, Deborah Chiabrando, Fiorella Altruda, Luca Munaron, Lorenzo Silengo, Veronica Fiorito, Giada Ingoglia, Francesca Vinchi, Stefano Carossa, Sara Petrillo
Publikováno v:
ResearcherID
Publons
Publons
Heme is required for cell respiration and survival. Nevertheless, its intracellular levels need to be finely regulated to avoid heme excess, which may catalyze the production of reactive oxygen species (ROS) and promote cell death. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c44ca07827f583fc881f6ca0ef2f66
https://doi.org/10.1038/s41418-017-0001-7
https://doi.org/10.1038/s41418-017-0001-7
Autor:
Qiang Tian, Christopher Lausted, Janis L. Abkowitz, Raymond T. Doty, Xiaowei Yan, Changting Meng
Publikováno v:
Exp Hematol
Rpl11 haploinsufficient mice develop a macrocytic anemia similar to patients with DBA. Here, we fully characterize this model from clinical and pathophysiological perspectives. Early erythroid precursors have increased heme content and high cytoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b7183ee6326131c4431addc45c9bf4
https://doi.org/10.1016/j.exphem.2021.02.010
https://doi.org/10.1016/j.exphem.2021.02.010
Publikováno v:
Journal of Bacteriology. 196:1335-1342
The reactive nature of heme enables its use as an enzymatic cofactor while rendering excess heme toxic. The importance of heme detoxification machinery is highlighted by the presence of various types of these homeostatic systems in Gram-positive and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cee9dab100ad457e5a37394d15775e
https://doi.org/10.1128/jb.01067-13
https://doi.org/10.1128/jb.01067-13
Autor:
Laurent Kiger, Sandia Adypagavane, Laura Bencheikh, Nicolas Hebert, Stephane Moutereau, Frédéric Galactéros, Michael Marden, Yves Beuzard, France Pirenne, Pablo Bartolucci
Publikováno v:
Blood. 134:3381-3381
Introduction: Hemolytic anemia combines 3 components to various extents: extravascular hemolysis, intravascular hemolysis and dyserythropoiesis. Global hemolysis in excess to defense lines induces oxidative and inflammatory syndromes and vascular dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3129a298bd463580b0e2259fe808f85a
https://doi.org/10.1182/blood-2019-130600
https://doi.org/10.1182/blood-2019-130600