Zobrazeno 1 - 10
of 1 473
pro vyhledávání: '"Heme biosynthesis"'
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
The heme synthase AhbD catalyzes the last step of the siroheme-dependent heme biosynthesis pathway, which is operative in archaea and sulfate-reducing bacteria. The AhbD-catalyzed reaction consists of the oxidative decarboxylation of two propionate s
Externí odkaz:
https://doaj.org/article/a0c30daf8b294d5a838ad051373c5bff
Autor:
Hadia Aftab, Rebecca K. Donegan
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Heme biosynthesis in the Gram-positive bacteria occurs mostly via a pathway that is distinct from that of eukaryotes and Gram-negative bacteria in the three terminal heme synthesis steps. In many of these bacteria heme is a necessary cofactor that fu
Externí odkaz:
https://doaj.org/article/ee766036931140ee88b59323d70f9c1b
Autor:
Toni Mingers, Stefan Barthels, Violetta Mass, José Manuel Borrero-de Acuña, Rebekka Biedendieck, Ana Cooke, Tamara A. Dailey, Svetlana Gerdes, Wulf Blankenfeldt, Harry A. Dailey, Martin J. Warren, Martina Jahn, Dieter Jahn
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Nature utilizes three distinct pathways to synthesize the essential enzyme cofactor heme. The coproporphyrin III-dependent pathway, predominantly present in Bacillaceae, employs an oxygen-dependent coproporphyrinogen III oxidase (CgoX) that converts
Externí odkaz:
https://doaj.org/article/c08797d53e68449fa3988cd244d0c552
Autor:
Tian Tian, Xinwei Wu, Pingping Wu, Xinyi Lu, Qi Wang, Yifan Lin, Canjie Liu, Jungang Zhou, Yao Yu, Hong Lu
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2024)
Soy leghemoglobin, when bound to heme, imparts a meat-like color and flavor and can serve as a substitute for animal-derived proteins. Enhancing cellular heme synthesis improves the recombinant expression of leghemoglobin in yeast. To achieve high-le
Externí odkaz:
https://doaj.org/article/0e7803fb516e4187a6eae2e6124d901c
Autor:
Shaomei Yang, Anlong Wang, Jiachang Li, Yunhang Shao, Fengjie Sun, Shucheng Li, Kai Cao, Hongliang Liu, Peng Xiong, Zhengquan Gao
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background Heme is an iron/porphyrin complex compound, widely used in the health care, food, and pharmaceutical industries. It is more advantageous and attractive to develop microbial cell factories to produce heme by fermentation, with lowe
Externí odkaz:
https://doaj.org/article/9fe7f0b34e1a4ea994d68f63beb02e04
Autor:
Jiyeun Park, Hyun-Hee Lee, Heeji Moon, Nahyun Lee, Sieun Kim, Jung-Eun Kim, Yoonji Lee, Kyunghun Min, Hun Kim, Gyung Ja Choi, Yin-Won Lee, Young-Su Seo, Hokyoung Son
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT In plant-pathogen interactions, oxidative bursts are crucial for plants to defend themselves against pathogen infections. Rapid production and accumulation of reactive oxygen species kill pathogens directly and cause local cell death, preven
Externí odkaz:
https://doaj.org/article/1688442c32674e89913752858b2f176c
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 16, Iss 1, Pp 1-11 (2023)
Abstract Background Heme has attracted much attention because of its wide applications in medicine and food. The products of genes hemBCDEFY convert 5-aminolevulinic acid to protoporphyrin IX (PPIX; the immediate precursor of heme); protoporphyrin fe
Externí odkaz:
https://doaj.org/article/8e3a4d35533244e398729928628e4bcf
Publikováno v:
Biology, Vol 12, Iss 12, p 1527 (2023)
Coproporphyrinogen oxidase (CgoX) and protoporphyrinogen oxidase (PgoX) catalyze the oxidation of the flexible cyclic tetrapyrrole of porphyrinogen compounds into fully conjugated, planar macrocyclic porphyrin compounds during heme biosynthesis. Thes
Externí odkaz:
https://doaj.org/article/eff91766a6a64e459c2ac5fb67d6e5f1
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 27 (2023)
Acute intermittent porphyria (AIP) is characterized by acute neurovisceral attacks that are precipitated by the induction of hepatic 5-aminolevulinic acid synthase 1 (ALAS1). In erythropoietic protoporphyria (EPP), sun exposure leads to skin photosen
Externí odkaz:
https://doaj.org/article/b2a9a0093e7c481e8dbbc7536f5301e4
Autor:
Laurie K. Jackson, Tammy A. Dailey, Brenden Anderle, Martin J. Warren, Hector A. Bergonia, Harry A. Dailey, John D. Phillips
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1485 (2023)
The final three steps of heme biogenesis exhibit notable differences between di- and mono-derm bacteria. The former employs the protoporphyrin-dependent (PPD) pathway, while the latter utilizes the more recently uncovered coproporphyrin-dependent (CP
Externí odkaz:
https://doaj.org/article/424c33bb97e640e3bd52c473917fdcd6