Zobrazeno 1 - 10
of 466
pro vyhledávání: '"Hematopoietic stem cell niche"'
Autor:
Wensheng Zhang, Yong Wang, Fushun Zhong, Xinghuan Wang, Robert Sucher, Cheng-Hung Lin, Gerald Brandacher, Mario G. Solari, Vijay S. Gorantla, Xin Xiao Zheng
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Compelling experimental evidence confirms that the robustness and longevity of mixed chimerism (MC) relies on the persistence and availability of donor-derived hematopoietic stem cell (HSC) niches in recipients. Based on our prior work in rodent vasc
Externí odkaz:
https://doaj.org/article/8e41af8c010d4f2db7bb8bea0a628768
Akademický článek
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Autor:
Carsten Riether
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Adult bone marrow (BM) hematopoietic stem cells (HSCs) are maintained in a quiescent state and sustain the continuous production of all types of blood cells. HSCs reside in a specialized microenvironment the so-called HSC niche, which equally promote
Externí odkaz:
https://doaj.org/article/6725390c867846bd91cf3ed50c8b7313
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Bone marrow microenvironment (BMM) has been proven to have benefits for both normal hematopoietic stem cell niche and pathological leukemic stem cell niche. In fact, the pathological leukemia microenvironment reprograms bone marrow niche cells, espec
Externí odkaz:
https://doaj.org/article/bbad234245804f2c9cffcefe508926c3
Autor:
V. I. Rugal, S. S. Bessmeltsev, N. Yu. Semenova, S. V. Gritsaev, I. I. Kostroma, N. I. Enukashvili, A. V. Chubar, D. A. Ivolgin
Publikováno v:
Сибирский научный медицинский журнал, Vol 39, Iss 1, Pp 112-118 (2019)
The purpose of the study is to evaluate the morphological and functional features of the tumor microenvironment and the cultural characteristics of mesenchymal stromal cells (MSC) of patients with multiple myeloma (MM) before and after treatment. Mat
Externí odkaz:
https://doaj.org/article/b0d8de79811c46788f3fc6713f7b2c9d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Self-renewal and multidirectional differentiation of hematopoietic stem cells (HSCs) are strictly regulated by numerous cellular components and cytokines in the bone marrow (BM) microenvironment. Several cell types that regulate HSC niche have been i
Externí odkaz:
https://doaj.org/article/e777af04aa4b41259248e8d6be2fbffb
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Acute myeloid leukemia (AML) is a heterogeneous, complex, and deadly disease, whose treatment has hardly evolved for decades and grounds on the use of intensive chemotherapy regimens. Chemotherapy helps reduce AML bulk, but promotes relapse in the lo
Externí odkaz:
https://doaj.org/article/73c104d8464042bc85811050c003b387
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Hematopoietic stem cells (HSCs) generated during embryonic development are able to maintain hematopoiesis for the lifetime, producing all mature blood lineages. HSC transplantation is a widely used cell therapy intervention in the treatment of hemato
Externí odkaz:
https://doaj.org/article/fd18f3ffe065439b9b60d3bddf23434d
Autor:
Yinghao Li, Da Huo, Wen Zeng, Dayu Sun, Chuhong Zhu, Mingcan Yang, Qin Zhongliang, Ju Tan, Ge Guan, Guanyuan Yang, Yanzhao Li, Xiaolin Zhao
Publikováno v:
Bioactive Materials
Bioactive Materials, Vol 6, Iss 12, Pp 4415-4429 (2021)
Bioactive Materials, Vol 6, Iss 12, Pp 4415-4429 (2021)
Cell therapy has been a promising strategy for cardiac repair after myocardial infarction (MI), but a poor ischemic environment and low cell delivery efficiency remain significant challenges. The spleen serves as a hematopoietic stem cell niche and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f9d6a962ae16bca52e8fe03cea07ef
https://doi.org/10.1016/j.bioactmat.2021.04.010
https://doi.org/10.1016/j.bioactmat.2021.04.010
Publikováno v:
ACS Biomaterials Science & Engineering. 7:2592-2604
The three-dimensional (3D) marrow microenvironment plays an essential role in regulating human cord blood-derived CD34+ cells (hCB-CD34+) migration, proliferation, and differentiation. Extensive in vitro and in vivo studies have aimed to recapitulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede507c4990ffd0375c9d04bac901173
https://doi.org/10.1021/acsbiomaterials.0c01297
https://doi.org/10.1021/acsbiomaterials.0c01297