Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Hematopoietic stem cell homeostasis"'
Publikováno v:
Stem Cells Dev
The core function of hematopoietic stem and progenitor cells (HSPCs) is to provide lifelong production of all lineages of the blood and immune cells. The mechanisms that modulate HSPC homeostasis and lineage biasing are not fully understood. Growing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98518e3609b4e1af413e0776fd2dbd01
https://doi.org/10.1089/scd.2021.0096
https://doi.org/10.1089/scd.2021.0096
Autor:
Viviane Baral, Liang He, Mallorie Depond, Fawzia Louache, Florian Beghi, Yanyan Zhang, Virginie Joulin, M. Wittner, Patrick Gonin, Adlen Foudi, Bo R. Rueda
Publikováno v:
Current Stem Cell Reports
Current Stem Cell Reports, Springer, 2019, 13 (2), pp.274-290. ⟨10.1016/j.stemcr.2019.06.002⟩
Stem Cell Reports, Vol 13, Iss 2, Pp 274-290 (2019)
Stem Cell Reports
Current Stem Cell Reports, Springer, 2019, 13 (2), pp.274-290. ⟨10.1016/j.stemcr.2019.06.002⟩
Stem Cell Reports, Vol 13, Iss 2, Pp 274-290 (2019)
Stem Cell Reports
Summary Bone marrow (BM) niche cells help to keep adult hematopoietic stem cells (HSCs) in a quiescent state via secreted factors and induction of cell-cycle inhibitors. Here, we demonstrate that the adapter protein CABLES1 is a key regulator of long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64650b58594faa031a5d1f8eb50f74fe
https://doi.org/10.1016/j.stemcr.2019.06.002
https://doi.org/10.1016/j.stemcr.2019.06.002
Publikováno v:
The Journal of Immunology. 204:3400-3415
Mixed-lineage leukemia 1 (MLL1), which exerts its H3K4 methyltransferase activity by interacting with WDR5, ASH2L, and RBBP5, plays a pivotal role in regulating hematopoietic stem cell homeostasis. Disrupting the integrity of MLL1-complex has been re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a86cd7b53965dd3d917a2fe5b8204d
https://doi.org/10.4049/jimmunol.2000230
https://doi.org/10.4049/jimmunol.2000230
Publikováno v:
Current Stem Cell Reports
Purpose of Review Hematopoietic stem cells (HSCs) sit at the top of the hierarchy that meets the daily burden of blood production. HSC maintenance relies on extrinsic cues from the bone marrow (BM) microenvironment to balance stem cell self-renewal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9917303d7cacfc9ad4adf0fce675ebee
https://pubmed.ncbi.nlm.nih.gov/34868826
https://pubmed.ncbi.nlm.nih.gov/34868826
Publikováno v:
Experimental hematology. 103
Hematopoietic stem cells (HSCs) are immature blood cells that exhibit multilineage differentiation capacity. Homeostasis is critical for HSC potential and lifelong hematopoiesis, and HSC homeostasis is tightly governed by both intrinsic molecular net
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bb9f1b28fc17ed8307e80beb13dc5c
https://pubmed.ncbi.nlm.nih.gov/34464661
https://pubmed.ncbi.nlm.nih.gov/34464661
Publikováno v:
Blood Science. 1:19-28
As one of the best characterized adult stem cells, hematopoietic stem cell (HSC) homeostasis is of great importance to hematopoiesis and immunity due to HSC's abilities of self-renewal and multi-lineage differentiation into functional blood cells. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522e38a5d55e9c75cf9090d7df470578
https://doi.org/10.1097/bs9.0000000000000018
https://doi.org/10.1097/bs9.0000000000000018
Autor:
Alan Le Mercier, Weijia Yu, Boris Strilic, Remy Bonnavion, Yannick Jäger, Xinyi Chen, Hyun-Woo Jeong, Mohamad Wessam Alnouri, Michael A. Rieger, Yang Zhang, Stefan Offermanns, Sophie Ramas, Kishor K. Sivaraj, Tjeerd Sijmonsma, Haaglim Cho, Timm Schroeder, Ralf H. Adams, Kenneth Anthony Roquid
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 118 (17)
Proceedings of the National Academy of Sciences of the United States of America, 118 (17)
G protein–coupled receptor 182 (GPR182) has been shown to be expressed in endothelial cells; however, its ligand and physiological role has remained elusive. We found GPR182 to be expressed in microvascular and lymphatic endothelial cells of most o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088d86aaf670dfd5c694c17127f3a38f
http://europepmc.org/articles/PMC8092405
http://europepmc.org/articles/PMC8092405
Autor:
Roberta Chirillo, Ilenia Aversa, Anna Di Vito, Alessandro Salatino, Anna Martina Battaglia, Alessandro Sacco, Maddalena Adriana Di Sanzo, Maria Concetta Faniello, Barbara Quaresima, Camillo Palmieri, Flavia Biamonte, Francesco Costanzo
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology, Vol 10 (2020)
The cell-microenvironment communication is essential for homing of hematopoietic stem cells in stromal niches. Recent evidences support the involvement of epithelial-to-mesenchymal (EMT) process in hematopoietic stem cell homeostasis as well as in le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bea41f91820118442d24ad59fbd5fa
https://pubmed.ncbi.nlm.nih.gov/32432042
https://pubmed.ncbi.nlm.nih.gov/32432042
Autor:
Karin M. Hoffmeister, Christian A. Di Buduo, Leonardo Rivadeneyra, Melissa M. Lee-Sundlov, Silvia Giannini, Joseph T.Y. Lau, Hervé Falet, Robert Burns, Alessandra Balduini
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Glycosylation is critical to megakaryocyte (MK) and thrombopoiesis in the context of gene mutations that affect sialylation and galactosylation. Here, we identify the conserved B4galt1 gene as a critical regulator of thrombopoiesis in MKs. β4GalT1 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e9e7fe5cb781752a1c1deb95bbf46f
https://doi.org/10.1038/s41467-019-14178-y
https://doi.org/10.1038/s41467-019-14178-y
Publikováno v:
Blood. 138:1083-1083
Though fatty acid oxidation has been shown to be essential for hematopoietic stem cell maintenance, the importance of fatty acid uptake from the bone marrow microenvironment vs. de novo lipogenesis has not been elucidated. The process of de novo lipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b23e8e61ee29962c24bdc8c77893775c
https://doi.org/10.1182/blood-2021-154053
https://doi.org/10.1182/blood-2021-154053