HIF-1α is a protective factor in conditional PHD2-βdeficient mice suffering from severe HIF-2-induced excessive erythropoiesis

Autor: Kathrin Geiger, Ben Wielockx, Guo-Hua Fong, Georg Breier, Vasuprada Iyengar, David M. Poitz, Max Gassmann, Gustavo B. Baretton, Joanna Kalucka, David R. Greaves, Teresa Otto, Alex M. Sykes, Alexander Weidemann, S. Bergmann, Steffen Jahn, Antje Muschter, Kristin Franke, Joachim Fandrey, Stefan R. Bornstein, Michael H. Muders, Rashim Pal Singh, Soulafa Mamlouk, Triantafyllos Chavakis, Kathrin Wieczorek, Tatsiana Ripich

Publikováno v: BLOOD
Franke, K, Kalucka, J, Mamlouk, S, Singh, R P, Muschter, A, Weidemann, A, Iyengar, V, Jahn, S, Wieczorek, K, Geiger, K, Muders, M, Sykes, A M, Poitz, D M, Ripich, T, Otto, T, Bergmann, S, Breier, G, Baretton, G, Fong, G-H, Greaves, D R, Bornstein, S, Chavakis, T, Fandrey, J, Gassmann, M & Wielockx, B 2013, ' HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis ', Blood, vol. 121, no. 8, pp. 1436-45 . https://doi.org/10.1182/blood-2012-08-449181

Erythropoiesis must be tightly balanced to guarantee adequate oxygen delivery to all tissues in the body. This process relies predominantly on the hormone erythropoietin (EPO) and its transcription factor hypoxia inducible factor (HIF). Accumulating

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https://hdl.handle.net/20.500.12866/10391