Výsledky vyhledávání - "Hematology/Hemoglobinopathies"

A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria

Autor: Tatiana M. Lopera-Mesa, Hisashi Fujioka, Nathaniel J. Brittain, Rick M. Fairhurst, Chanaki Amaratunga, Rushina Cholera, Takayuki Arie, Jeffrey R. Keefer

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e14798 (2011)
PLoS ONE

Background In Africa, infant susceptibility to Plasmodium falciparum malaria increases substantially as fetal hemoglobin (HbF) and maternal immune IgG disappear from circulation. During the first few months of life, however, resistance to malaria is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e46c76a96ccb9bd100338ecbccb42de
http://europepmc.org/articles/PMC3075246?pdf=render

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Mortality in sickle cell anemia in Africa: a prospective cohort study in Tanzania

Publikováno v: PLoS ONE
PLOS ONE, 6 (2), Article e14699. (2011)
PLoS ONE, Vol 6, Iss 2, p e14699 (2011)

Background:The World Health Organization has declared Sickle Cell Anemia (SCA) a public health priority. There are 300,000 births/year, over 75% in Africa, with estimates suggesting that 6 million Africans will be living with SCA if average survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce95a10aaf2d5b21995c46604c82ff40
https://researchonline.lshtm.ac.uk/id/eprint/1154/1/pone.0014699.pdf

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The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity

Autor: Fabrizia Urbinati, H. Leighton Grimes, Punam Malik, Tomoyasu Higashimoto, Paritha Arumugam, Chinavenmeni S. Velu

Publikováno v: PLoS ONE, Vol 4, Iss 9, p e6995 (2009)
PLoS ONE

Chromatin insulators separate active transcriptional domains and block the spread of heterochromatin in the genome. Studies on the chicken hypersensitive site-4 (cHS4) element, a prototypic insulator, have identified CTCF and USF-1/2 motifs in the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c4abd5a6839a7cce72ca12f5fa0c03
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19746166/pdf/?tool=EBI

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Gene Specificity of Suppression of Transgene-Mediated Insertional Transcriptional Activation by the Chicken HS4 Insulator

Autor: Romain Desprat, Eric E. Bouhassira

Publikováno v: PLoS ONE
PLoS ONE, Vol 4, Iss 6, p e5956 (2009)

Insertional mutagenesis has emerged as a major obstacle for gene therapy based on vectors that integrate randomly in the genome. Reducing the genotoxicity of genomic viral integration can, in first approximation, be equated with reducing the risk of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f050d87e2d523d590a2bcdd3a195c8
http://europepmc.org/articles/PMC2694267

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Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients

Autor: Swee Lay Thein, Pinar Ulug, Lisa E. Creary, Colin A. McKenzie, Martin Farrall, Stephan Menzel, Terrence Forrester, Veronica Taylor, Neil A. Hanchard

Publikováno v: PLoS ONE, Vol 4, Iss 1, p e4218 (2009)
King's College London
PLoS ONE

Fetal haemoglobin (HbF) is a major ameliorating factor in sickle cell disease. We investigated if a quantitative trait locus on chromosome 6q23 was significantly associated with HbF and F cell levels in individuals of African descent. Single nucleoti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9933512ef8191f36f0cd8e0f75b26b0
http://hdl.handle.net/10044/1/57625

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Statistical dynamics of flowing red blood cells by morphological image processing

Autor: David T. Eddington, John M. Higgins, Sangeeta N. Bhatia, Lakshminarayanan Mahadevan

Publikováno v: PLoS Computational Biology
PLoS
PLoS Computational Biology, Vol 5, Iss 2, p e1000288 (2009)

Blood is a dense suspension of soft non-Brownian cells of unique importance. Physiological blood flow involves complex interactions of blood cells with each other and with the environment due to the combined effects of varying cell concentration, cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871c95804d1cd68e324ceb979b836202
https://pubmed.ncbi.nlm.nih.gov/19214200

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The Genomic Analysis of Erythrocyte microRNA Expression in Sickle Cell Diseases

Autor: Jen-Tsan Chi, Shao-Yin Chen, Marilyn J. Telen, Yulei Wang

Publikováno v: PLoS ONE
PLoS ONE, Vol 3, Iss 6, p e2360 (2008)

BackgroundSince mature erythrocytes are terminally differentiated cells without nuclei and organelles, it is commonly thought that they do not contain nucleic acids. In this study, we have re-examined this issue by analyzing the transcriptome of a pu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01eff43c668b922ba61555005a3c846e
http://europepmc.org/articles/PMC2408759

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Beta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapy

Autor: Eden Fussner, Angela Moffett, James Ellis, Mandy Y. M. Lo, Alla Buzina, David P. Bazett-Jones, Peter Pasceri, Rikki R. Bharadwaj, Akitsu Hotta, J. Victor Garcia-Martinez

Publikováno v: PLoS Genetics, Vol 4, Iss 4, p e1000051 (2008)
PLoS Genetics

The Locus Control Region (LCR) requires intronic elements within β-globin transgenes to direct high level expression at all ectopic integration sites. However, these essential intronic elements cannot be transmitted through retrovirus vectors and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75477a6af3c45ce414ff21a9770bc56
http://europepmc.org/articles/PMC2271131?pdf=render

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HIGH RISK OF SEVERE ANAEMIA AFTER CHLOROPROGUANIL-DAPSONE+ARTESUNATE ANTIMALARIAL TREATMENT IN PATIENTS WITH G6PD(A-) DEFICIENCY

Autor: Aline Uwimana, David Modiano, Umberto D'Alessandro, Pamela Avellino, Corine Karema, Sue J. Lee, Germana Bancone, Caterina I. Fanello

Publikováno v: PLoS ONE
PLoS ONE, Vol 3, Iss 12, p e4031 (2008)

Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited human enzyme defect. This deficiency provides some protection from clinical malaria, but it can also cause haemolysis after administration of drugs with oxida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc99d83fea4a1b1d5d3226a7ad4a15f
http://hdl.handle.net/11573/364997

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