Výsledky vyhledávání - "Hematology/Coagulation Disorders"

Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation

Autor: Judith M.E.M. Cosemans, Matthew T. Harper, Johan W. M. Heemskerk, Karen Gilio, Alastair W. Poole, Kellie J. Hall

Publikováno v: PLoS ONE
PLoS ONE, Vol 3, Iss 9, p e3277 (2008)

BACKGROUND: PKCtheta is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKCtheta(-/-) T cells exhibit reduced activation and PKCtheta(-/-) mice are resistant to autoimmune disease, making PKCtheta an attractive the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0816b62cd637f333d1eaaef3e6ee83

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Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity

Autor: Alice Cheng, Dominique Missiakas, Hwan Keun Kim, Taeok Bae, Olaf Schneewind, Molly Mcadow

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 6, Iss 8, p e1001036 (2010)

The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde534807a293960eb1d7c14a62b6193
http://europepmc.org/articles/PMC2916881

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Anticoagulation after anterior myocardial infarction and the risk of stroke

Autor: Jacob A. Udell, Julie T. Wang, Jack V. Tu, David J. Gladstone

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12150 (2010)
PLoS ONE

BackgroundSurvivors of anterior MI are at increased risk for stroke with predilection to form ventricular thrombus. Commonly patients are discharged on dual antiplatelet therapy. Given the frequency of early coronary reperfusion and risk of bleeding,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b277e069ca54dd8003216c48b3c7453
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20730096/pdf/?tool=EBI

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Pathogen Entrapment by Transglutaminase—A Conserved Early Innate Immune Mechanism

Autor: Heiko Herwald, Martina Klupp, Richard M. Cripps, Pavel Dobeš, Ulrich Theopold, Matthias Mörgelin, Torsten G. Loof, Pavel Hyršl, Jennifer Ikle, Zhi Wang, Olga Loseva, Christine Wilhelmsson

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 6, Iss 2, p e1000763 (2010)

Clotting systems are required in almost all animals to prevent loss of body fluids after injury. Here, we show that despite the risks associated with its systemic activation, clotting is a hitherto little appreciated branch of the immune system. We c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee88ab8b971e0a1824c6b70e969c55e
http://europepmc.org/articles/PMC2820530

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Endothelial Cell Processing and Alternatively Spliced Transcripts of Factor VIII: Potential Implications for Coagulation Cascades and Pulmonary Hypertension

Autor: Michael Laffan, Claire L. Shovlin, Richard A. Manning, Graeme M. Birdsey, Fatima S Govani, Gillian Angus, IG Mollet, Francesco Mauri, Grace N Okoli, Kay Elderfield

Publikováno v: PLoS ONE
e9154
PLoS ONE, Vol 5, Iss 2, p e9154 (2010)

Background Coagulation factor VIII (FVIII) deficiency leads to haemophilia A. Conversely, elevated plasma levels are a strong predictor of recurrent venous thromboemboli and pulmonary hypertension phenotypes in which in situ thromboses are implicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42152af5ae1076a29340ddbd7747da2
http://europepmc.org/articles/PMC2823490

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Evolution of primary hemostasis in early vertebrates

Autor: Vrinda Kulkarni, Maira Carrillo, Pudur Jagadeeswaran, Seongcheol Kim

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8403 (2009)
PLoS ONE

Hemostasis is a defense mechanism which protects the organism in the event of injury to stop bleeding. Recently, we established that all the known major mammalian hemostatic factors are conserved in early vertebrates. However, since their highly vasc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01467230791ae549ac249e0ae173aaab
http://europepmc.org/articles/PMC2793433?pdf=render

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Identifying blood biomarkers and physiological processes that distinguish humans with superior performance under psychological stress

Autor: Shane C. Burgess, Russell S. Stocker, Nausheen Momen, Amanda M. Cooksey

Publikováno v: PLoS ONE
PLoS ONE, Vol 4, Iss 12, p e8371 (2009)

Background Attrition of students from aviation training is a serious financial and operational concern for the U.S. Navy. Each late stage navy aviator training failure costs the taxpayer over $1,000,000 and ultimately results in decreased operational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9975fa9759652c3d8aeeb3889de90b
https://pubmed.ncbi.nlm.nih.gov/20020041

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Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling

Autor: Ricardo Martín Gómez, Carolina Jaquenod De Giusti, Mirta Schattner, Lina Paola D'Atri, Agustín Enrique Ure, Roberto Gabriel Pozner, Oscar B. Torres, Joseph E. Italiano, Víctor Romanowski

Publikováno v: PLoS Pathogens
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
PLoS Pathogens, Vol 6, Iss 4, p e1000847 (2010)

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by Junín virus (JUNV), a member of the arenaviridae family. Although a recently introduced live attenuated vaccine has proven to be effective, AHF remains a potentially lethal in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19899fb818dd0feee90e5198261b19c
https://pubmed.ncbi.nlm.nih.gov/20419155

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The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity

Autor: Fabrizia Urbinati, H. Leighton Grimes, Punam Malik, Tomoyasu Higashimoto, Paritha Arumugam, Chinavenmeni S. Velu

Publikováno v: PLoS ONE, Vol 4, Iss 9, p e6995 (2009)
PLoS ONE

Chromatin insulators separate active transcriptional domains and block the spread of heterochromatin in the genome. Studies on the chicken hypersensitive site-4 (cHS4) element, a prototypic insulator, have identified CTCF and USF-1/2 motifs in the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c4abd5a6839a7cce72ca12f5fa0c03
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19746166/pdf/?tool=EBI

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Models for prediction of factor VIII half-life in severe haemophiliacs:Distinct approaches for blood group O and non-O patients

Autor: Peter J. Lenting, Krista Fischer, Ronan Pendu, Carina J. van Schooten, Cécile V. Denis, Karin van Dijk, H. Marijke van den Berg

Publikováno v: Fischer, K, Pendu, R, van Schooten, C J, van Dijk, K, Denis, C V, van den Berg, H M & Lenting, P J 2009, ' Models for prediction of factor VIII half-life in severe haemophiliacs : Distinct approaches for blood group O and non-O patients ', PLoS ONE, vol. 4, no. 8, e6745 . https://doi.org/10.1371/journal.pone.0006745
PLoS ONE, Vol 4, Iss 8, p e6745 (2009)
PLoS ONE, 4(8):e6745. Public Library of Science
PLoS ONE

Background: Von Willebrand factor (VWF) is critical for the in vivo survival of factor VIII (FVIII). Since FVIII half-life correlates with VWF-antigen pre-infusion levels, we hypothesized that VWF levels are useful to predict FVIII half-life. Methodo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa11f1caf9a657fc6db4a23a11c3d135
https://research.vumc.nl/en/publications/f7085726-1c37-4c3e-9f4a-b3736fc00755

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