Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Hemant R Jadhav"'
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Background To overcome the problem of side effects and toxicity, development of new anticancer agents is needed. Recently, piperidine salicylanilide derivatives with nanomolar epidermal growth factor receptor (EGFR) inhibitory and cytotoxici
Externí odkaz:
https://doaj.org/article/12d0957d1ab54029906280b6c6488bb6
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
It is estimated that the human genome encodes 15% of proteins that are considered to be disease-modifying. Only 2% of these proteins possess a druggable site that the approved clinical candidates target. Due to this disparity, there is an immense nee
Externí odkaz:
https://doaj.org/article/547a1112b03b447a898d1cc7c8918b91
Autor:
Mohd Abdullaha, Razia Banoo, Vijay K. Nuthakki, Mohit Sharma, Sukhleen Kaur, Shikha Thakur, Ajay Kumar, Hemant R. Jadhav, Sandip B. Bharate
Publikováno v:
ACS Omega. 8:17591-17608
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73275e23808c3f40458200992aa6c008
https://doi.org/10.1021/acsomega.2c08167
https://doi.org/10.1021/acsomega.2c08167
Publikováno v:
Current Topics in Medicinal Chemistry. 20:1522-1534
Glycogen Synthase Kinase 3 (GSK3) is one of the Serine/Threonine protein kinases, which has gained a lot of attention for its role in a variety of pathways. It has two isoforms, GSK3α and GSK3β. However, GSK3β is highly expressed in different area
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b139d725bb6c1052a543d0bbb85cae60
https://doi.org/10.2174/1568026620666200516153136
https://doi.org/10.2174/1568026620666200516153136
Publikováno v:
Letters in Drug Design & Discovery. 17:418-427
Background: A series of eighteen 2-Oxo-N-substituted phenyl- 2H-chromene-3- carboxamide analogues has been evaluated for HIV-1 integrase (IN) inhibition. Methods: The derivatives were synthesized via a two-step pathway commencing with 2- hydroxybenza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d78dc2ec832689cf025a38e3e6f85a38
https://doi.org/10.2174/1570180816666190617150803
https://doi.org/10.2174/1570180816666190617150803
Publikováno v:
Scopus-Elsevier
In the present study, a series of indole-3-carbaldehydes having substituted N-sulfonyl phenyl or Nphenacyl group was synthesized and evaluated for anti-HIV activity, in particular, in vitro and in silico HIV-1 integrase inhibition. Three compounds (8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0991d5a13ab337eca570b7dc468f13
https://doi.org/10.53879/id.57.02.11912
https://doi.org/10.53879/id.57.02.11912
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ecf6426114b57d9788bfde136a40d83
https://doi.org/10.2139/ssrn.4133494
https://doi.org/10.2139/ssrn.4133494
Publikováno v:
Anti-Infective Agents. 17:105-114
Background: A series of novel 3-(1,3-dioxoisoindolin-2-yl)-N-substituted phenyl benzamide derivatives was synthesized and tested in vitro against human immunodeficiency virus type-1 Integrase (HIV-1 IN). Methods: Out of the 18 analogues, six (compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deea380cebf740e6a1992a189419c367
https://doi.org/10.2174/2211352516666181102121920
https://doi.org/10.2174/2211352516666181102121920
Pharmaceutical researchers are constantly looking for drug products, drug delivery systems and devices for improving the health of society. A scientific and systematic search for new knowledge requires a thorough understanding of research methods and
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 17(10)
Alzheimer’s disease is one of the most common neurodegenerative disorder afflicting a large mass of population. BACE-1 (β-secretase) is an aspartyl protease of the amyloidogenic pathway considered responsible for Alzheimer’s disease (AD). Since
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07468c99ffbffebf8b67fe3f84ca12c4
https://pubmed.ncbi.nlm.nih.gov/33349218
https://pubmed.ncbi.nlm.nih.gov/33349218