Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Hemant M. Kocher"'
Autor:
Gabriel A. Aguirre, Michelle R. Goulart, Barts Pancreas Tissue Bank, Jesmond Dalli, Hemant M. Kocher
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/7cbed1be824c42178dfe973bfdbd0d2f
Autor:
Gabriel A. Aguirre, Michelle R. Goulart, Barts Pancreas Tissue Bank, Jesmond Dalli, Hemant M. Kocher
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Activation of pancreatic stellate cells (PSCs) to cancer-associated fibroblasts (CAFs) is responsible for the extensive desmoplastic reaction observed in PDAC stroma: a key driver of pancreatic ductal adenocarcinoma (PDAC) chemoresistance leading to
Externí odkaz:
https://doaj.org/article/4997d9d959754e02bca051383bcca64b
Autor:
Olalekan H. Usman, Liting Zhang, Gengqiang Xie, Hemant M. Kocher, Chang-il Hwang, Yue Julia Wang, Xian Mallory, Jerome Irianto
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract The establishment of patient-derived pancreatic cancer organoid culture in recent years creates an exciting opportunity for researchers to perform a wide range of in vitro studies on a model that closely recapitulates the tumor. One of the o
Externí odkaz:
https://doaj.org/article/3a41ca1bac8a43188228952c1df43c8d
Autor:
Patrick V. Lawrence, Krisha Desai, Christopher Wadsworth, Nagina Mangal, Hemant M. Kocher, Nagy Habib, Anguraj Sadanandam, Mikael H. Sodergren
Publikováno v:
Current Oncology, Vol 29, Iss 10, Pp 6754-6763 (2022)
Background: Most patients with pancreatic ductal adenocarcinoma (PDAC) are metastatic at presentation with dismal prognosis warranting improved systemic therapy options. Longitudinal sampling for the assessment of treatment response poses a challenge
Externí odkaz:
https://doaj.org/article/d123e1a762b94871b2cc312440ff6c7f
Autor:
Lavanya Sivapalan, Graeme J. Thorn, Emanuela Gadaleta, Hemant M. Kocher, Helen Ross-Adams, Claude Chelala
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-17 (2022)
Abstract Background The utility of circulating tumour DNA (ctDNA) for longitudinal tumour monitoring in pancreatic ductal adenocarcinoma (PDAC) has not been explored beyond mutations in the KRAS proto-oncogene. Here, we aimed to characterise and trac
Externí odkaz:
https://doaj.org/article/f03d4864c59b41ca8e5c3d44dd567d9c
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Pancreatic cancer risk is poorly quantified in relation to the temporal presentation of medical comorbidities and lifestyle. This study aimed to examine this aspect, with possible influence of demographics. Methods We conducted a
Externí odkaz:
https://doaj.org/article/25ed823fd3654f7f99f113961c10c338
Autor:
Renato B. Baleeiro, Christian J. Bouwens, Peng Liu, Carmela Di Gioia, Louisa S. Chard Dunmall, Ai Nagano, Rathistevy Gangeswaran, Claude Chelala, Hemant M. Kocher, Nicholas R. Lemoine, Yaohe Wang
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
MHC class II expression is a hallmark of professional antigen-presenting cells and key to the induction of CD4+ T helper cells. We found that these molecules are ectopically expressed on tumor cells in a large proportion of patients with pancreatic d
Externí odkaz:
https://doaj.org/article/aa1693edb0764d5493563bed35308e13
Autor:
Michelle R. Goulart, Jennifer Watt, Imran Siddiqui, Rita T. Lawlor, Ahmet Imrali, Christine Hughes, Amina Saad, Joanne ChinAleong, Chris Hurt, Catrin Cox, Roberto Salvia, Alberto Mantovani, Tatjana Crnogorac-Jurcevic, Somnath Mukherjee, Aldo Scarpa, Paola Allavena, Hemant M. Kocher
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-10 (2021)
Abstract Pancreatic ductal adenocarcinoma (PDAC), characterized by dense desmoplastic stroma laid down by pancreatic stellate cells (PSC), has no reliable diagnostic biomarkers for timely detection. A multi-center cohort of PDAC patients and controls
Externí odkaz:
https://doaj.org/article/e6dda48966e7423ba07476657d983905
Autor:
Francesca R. Delvecchio, Rachel E.A. Fincham, Sarah Spear, Andrew Clear, Marina Roy-Luzarraga, Frances R. Balkwill, John G. Gribben, Michele Bombardieri, Kairbaan Hodivala-Dilke, Melania Capasso, Hemant M. Kocher
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1543-1565 (2021)
Background and aims: The presence of tertiary lymphoid structures (TLSs) may confer survival benefit to patients with pancreatic ductal adenocarcinoma (PDAC), in an otherwise immunologically inert malignancy. Yet, the precise role in PDAC has not bee
Externí odkaz:
https://doaj.org/article/b635dee8c698441ab3175efcb13b1c08
Autor:
Hemant M. Kocher, Bristi Basu, Fieke E. M. Froeling, Debashis Sarker, Sarah Slater, Dominic Carlin, Nandita M. deSouza, Katja N. De Paepe, Michelle R. Goulart, Christine Hughes, Ahmet Imrali, Rhiannon Roberts, Maria Pawula, Richard Houghton, Cheryl Lawrence, Yathushan Yogeswaran, Kelly Mousa, Carike Coetzee, Peter Sasieni, Aaron Prendergast, David J. Propper
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
All-trans retinoic acid - ATRA- is known to remodulate the stroma of pancreatic cancer in mice. Here, the authors carried out a Phase Ib trial in pancreatic patients and show that ATRA in combination with chemotherapy is a safe potential treatment fo
Externí odkaz:
https://doaj.org/article/7c7d3ad82a9e4375ae3a8da492b9ac27