Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hemamali J. Warshakoon"'
Autor:
Tyler C. Lewis, Rajalakshmi Balakrishna, Hemamali J. Warshakoon, Geetanjali Agnihotri, Breanna M. Crall, Timothy P. Day, Subbalakshmi S. Malladi, Sunil A. David
Publikováno v:
Journal of Medicinal Chemistry. 54:8148-8160
Toll-like receptor 2-agonistic lipopeptides typified by S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-R-cysteinyl-S-serine (PAM(2)CS) compounds are potential vaccine adjuvants. In continuation of previously reported structure-activity relationships on this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdda1cdd3e1e686d17dccd9375430a7f
https://doi.org/10.1021/jm201071e
https://doi.org/10.1021/jm201071e
Autor:
Sunil A. David, Xinkun Wang, Hemamali J. Warshakoon, Subbalakshmi S. Malladi, Nikunj M. Shukla, Matthew R. Kimbrell, Jennifer D. Hood
Publikováno v:
Human Vaccines. 6:322-335
There is a pressing need for the development of novel, safe and effective adjuvants. The recent discovery and characterization of pathogen-associated molecular pattern (PAMP)-recognizing elements such as the Toll-like, NOD-like and RIG-like receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40373f926b0c3cb5c051284800e24b76
https://doi.org/10.4161/hv.6.4.10866
https://doi.org/10.4161/hv.6.4.10866
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:57-62
We have recently confirmed that lipoteichoic acid (LTA), a major constituent of the gram-positive bacterial surface, is the endotoxin of gram-positive bacteria that induces proinflammatory molecules in a Toll-like receptor 2 (TLR2)-dependent manner.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b83a7eedd13e6aafcbcabef41753e30
https://doi.org/10.1128/aac.00812-08
https://doi.org/10.1128/aac.00812-08
Autor:
Diptesh Sil, Hemamali J. Warshakoon, Thuan B. Nguyen, Sunil A. David, Stewart J. Wood, E. V. K. Suresh Kumar, Apurba Datta, Kelly A. Miller
Publikováno v:
Molecular Pharmaceutics. 5:1131-1137
Hydrophobically substituted polyamine compounds, particularly N-acyl or N-alkyl derivatives of homospermine, are potent endotoxin (lipopolysaccharide) sequestrants. Despite their polycationic nature, the aqueous solubilites are limited owing to the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6ebce9244a2cde4fc91f63623b467a
https://doi.org/10.1021/mp8001123
https://doi.org/10.1021/mp8001123
Autor:
Rajalakshmi Balakrishna, Hemamali J. Warshakoon, Cole A. Mutz, Nikunj M. Shukla, Sunil A. David, Subbalakshmi S. Malladi
Toll-like receptors (TLRs) are pattern recognition receptors that recognize specific molecular patterns present in molecules that are broadly shared by pathogens but are structurally distinct from host molecules. The TLR7-agonistic imidazoquinolines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bedd4bcd5c13377078cbb69273fe7de
https://europepmc.org/articles/PMC3276691/
https://europepmc.org/articles/PMC3276691/
Autor:
Rehman Ukani, Wenyan Wu, Sunil A. David, Hemamali J. Warshakoon, Subbalakshmi S. Malladi, Timothy P. Day, Tyler C. Lewis
A bis-quinoline compound, (7-chloro-N-(4-(7-chloroquinolin-4-ylamino)butyl)quinolin-4-amine; RE-660) was found to have C–C chemokine receptor type 1 (CCR1)-agonistic properties. RE-660 displayed strong adjuvantic activity in mice when co-administer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f38a6c06e7af71e70d398ea14b527cc
https://europepmc.org/articles/PMC3248955/
https://europepmc.org/articles/PMC3248955/
Autor:
Rajalakshmi Balakrishna, Hemamali J. Warshakoon, Rehman Ukani, Sunil A. David, Subbalakshmi S. Malladi, Geetanjali Agnihotri, Xinkun Wang
Publikováno v:
Journal of medicinal chemistry. 54(5)
N-acyl-γ-glutamyl-diaminopimelic acid is a prototype ligand for Nod1. We report a detailed SAR of C12-γ-D-Glu-DAP. Analogues with glutaric or γ-aminobutyric acid replacing the glutamic acid show greatly attenuated Nod1-agonistic activity. Substitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186dc57dacafcbea713fc942475112f4
https://pubmed.ncbi.nlm.nih.gov/21299227
https://pubmed.ncbi.nlm.nih.gov/21299227
Autor:
Sunil A. David, Hemamali J. Warshakoon, Rehman Ukani, Nikunj M. Shukla, David S. Moore, Cole A. Mutz
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
Toll-like receptor (TLR)-7 agonists show prominent immunostimulatory activities. The synthesis of a TLR7-active N(1)-(4-aminomethyl)benzyl substituted imidazoquinoline 5d served as a convenient precursor for the covalent attachment of fluorophores wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10f37fe34326236f616b5314db8f9db
https://pubmed.ncbi.nlm.nih.gov/20933417
https://pubmed.ncbi.nlm.nih.gov/20933417
Autor:
Subbalakshmi S. Malladi, Apurba Datta, Wenyan Wu, Matthew R. Kimbrell, Rehman Ukani, Sunil A. David, Hemamali J. Warshakoon, Michael W. Amolins, Rongti Li
The N-termini of bacterial lipoproteins are acylated with a (S)-(2,3-bisacyloxypropyl)cysteinyl residue. Lipopeptides derived from lipoproteins activate innate immune responses by engaging Toll-like receptor 2 (TLR2) and are highly immunostimulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9564299d62546a9905398a35a9b4bd11
https://europepmc.org/articles/PMC2859677/
https://europepmc.org/articles/PMC2859677/
Autor:
Hemamali J. Warshakoon, Matthew R. Kimbrell, Diptesh Sil, Timothy P. Day, Sunil A. David, Subbalakshmi S. Malladi, Samusi A. Adediran
Publikováno v:
Molecular pharmaceutics. 6(5)
Amphotericin B (AmB), a well-known polyene antifungal agent, displays a marked tendency to self-associate and, as a consequence, exhibits very poor solubility in water. The therapeutic index of AmB is low and is associated with significant dose-relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7cac166fd2d89965f6c441debc33980
https://pubmed.ncbi.nlm.nih.gov/19663403
https://pubmed.ncbi.nlm.nih.gov/19663403