Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Hemali Amunugama"'
Publikováno v:
Molecular Pharmacology. 80:839-847
We have investigated the mechanisms by which clopidogrel inactivates human cytochrome P450 2B6 (CYP2B6) in a reconstituted system. It was found that clopidogrel and its thiolactone metabolite, 2-oxo-clopidogrel, both inactivate CYP2B6 in a time- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93a8373c076677851d72d84d31e694c
https://doi.org/10.1124/mol.111.073783
https://doi.org/10.1124/mol.111.073783
Autor:
Tracey Boncher, Hemali Amunugama, Robert A. Casero, M.D. Thulani Senanayake, Patrick M. Woster
Publikováno v:
Essays in Biochemistry. 46:77-94
Enzymes in the biosynthetic and catabolic polyamine pathway have long been considered targets for drug development, and early drug discovery efforts in the polyamine area focused on the design and development of specific inhibitors of the biosyntheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfdb01df24ddc8a11526a3a5db75b8f
https://doi.org/10.1042/bse0460006
https://doi.org/10.1042/bse0460006
Methadone is a μ-opioid receptor agonist widely used in the treatment of narcotic addiction and chronic pain conditions. Methadone is metabolized predominantly in the liver by cytochromes P450 to its pharmacologically inactive primary metabolite 2-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a1f12da083bda560a31dc23160e42c
https://europepmc.org/articles/PMC3422545/
https://europepmc.org/articles/PMC3422545/
