Zobrazeno 1 - 10
of 335
pro vyhledávání: '"Hemal H. Patel"'
Autor:
Beatrice A. Golomb, Roel Sanchez Baez, Jan M. Schilling, Mehul Dhanani, McKenzie J. Fannon, Brinton K. Berg, Bruce J. Miller, Pam R. Taub, Hemal H. Patel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Gulf War illness (GWI) is an important exemplar of environmentally-triggered chronic multisymptom illness, and a potential model for accelerated aging. Inflammation is the main hypothesized mechanism for GWI, with mitochondrial impairment al
Externí odkaz:
https://doaj.org/article/c96f6dc30f414d43a2648e2e3b97e337
Autor:
Juan P. Zuniga-Hertz, Ramamurthy Chitteti, Joe Dispenza, Raphael Cuomo, Jacqueline A. Bonds, Elena L. Kopp, Sierra Simpson, Jonathan Okerblom, Svetlana Maurya, Brinda K. Rana, Atsushi Miyonahara, Ingrid R. Niesman, Jacqueline Maree, Gianna Belza, Hillari D. Hamilton, Carla Stanton, David J. Gonzalez, Michelle A. Poirier, Tobias Moeller-Bertram, Hemal H. Patel
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 32, Iss , Pp 100675- (2023)
The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide. Management of the pandemic has relied mainly on SARS-CoV-2 vaccines, while alternative approaches such as meditation, shown to improve immunity, have been largely un
Externí odkaz:
https://doaj.org/article/dfbdeaceac4345899555a7cf3860a8bb
Autor:
Elena L. Kopp, Daniel N. Deussen, Raphael Cuomo, Reinhard Lorenz, David M. Roth, Sushil K. Mahata, Hemal H. Patel
Publikováno v:
Cells, Vol 12, Iss 24, p 2786 (2023)
Type 2 diabetes (T2D) has a complex pathophysiology which makes modeling the disease difficult. We aimed to develop a novel model for simulating T2D in vitro, including hyperglycemia, hyperlipidemia, and variably elevated insulin levels targeting mus
Externí odkaz:
https://doaj.org/article/e19c7bd6e49641b7a54de4fd681033b0
Autor:
Young Song, Joseph Leem, Mehul Dhanani, M. Dan McKirnan, Yasuhiro Ichikawa, Julie Braza, Elizabeth O. Harrington, H. Kirk Hammond, David M. Roth, Hemal H. Patel
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
Role of blood-based factors in development and progression of heart failure (HF) is poorly characterized. Blood contains factors released during pathophysiological states that may impact cellular function and provide mechanistic insights to HF manage
Externí odkaz:
https://doaj.org/article/308d08b0074848d983fb435b6412f387
Autor:
Engy A. Abdel-Rahman, Salma Hosseiny, Abdullah Aaliya, Mohamed Adel, Basma Yasseen, Abdelrahman Al-Okda, Yasmine Radwan, Saber H. Saber, Nada Elkholy, Eslam Elhanafy, Emily E. Walker, Juan P. Zuniga-Hertz, Hemal H. Patel, Helen R. Griffiths, Sameh S. Ali
Publikováno v:
Journal of Advanced Research, Vol 31, Iss , Pp 35-47 (2021)
Introduction: Incidents of myocardial infarction and sudden cardiac arrest vary with time of the day, but the mechanism for this effect is not clear. We hypothesized that diurnal changes in the ability of cardiac mitochondria to control calcium homeo
Externí odkaz:
https://doaj.org/article/5eaed48a125146708a2de0aabcb8bc0f
Autor:
Shanshan Wang, Joseph S. Leem, Sonia Podvin, Vivian Hook, Natalia Kleschevnikov, Paul Savchenko, Mehul Dhanani, Kimberly Zhou, Isabella C. Kelly, Tong Zhang, Atsushi Miyanohara, Phuong Nguyen, Alexander Kleschevnikov, Steve L. Wagner, John Q. Trojanowski, David M. Roth, Hemal H. Patel, Piyush M. Patel, Brian P. Head
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 434-450 (2021)
Alzheimer’s disease (AD) is the most common form of neurodegeneration and cognitive dysfunction in the elderly. Identifying molecular signals that mitigate and reverse neurodegeneration in AD may be exploited therapeutically. Transgenic AD mice (PS
Externí odkaz:
https://doaj.org/article/9a008a9a994349fab892e7d7e193a9c9
Autor:
Shanshan Wang, Taiga Ichinomiya, Paul Savchenko, Swetha Devulapalli, Dongsheng Wang, Gianna Beltz, Takashi Saito, Takaomi C. Saido, Steve L. Wagner, Hemal H. Patel, Brian P. Head
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Mitochondria play a crucial role in Alzheimer's disease (AD) onset and progression. Traditional transgenic AD mouse models which were widely used in the past decades share a common limitation: The overexpression of APP and overproduction of amyloid-b
Externí odkaz:
https://doaj.org/article/00ff52210f1f4e91aec4043d0ef48315
Autor:
Ying Jiang, Sarah Krantz, Xiang Qin, Shun Li, Hirushi Gunasekara, Young-Mee Kim, Adriana Zimnicka, Misuk Bae, Ke Ma, Peter T. Toth, Ying Hu, Ayesha N. Shajahan-Haq, Hemal H. Patel, Saverio Gentile, Marcelo G. Bonini, Jalees Rehman, Yiyao Liu, Richard D. Minshall
Publikováno v:
Redox Biology, Vol 52, Iss , Pp 102304- (2022)
As essential regulators of mitochondrial quality control, mitochondrial dynamics and mitophagy play key roles in maintenance of metabolic health and cellular homeostasis. Here we show that knockdown of the membrane-inserted scaffolding and structural
Externí odkaz:
https://doaj.org/article/5ff54eba886243c59a38ab64bfa4363d
Autor:
Gerburg K. Schwaerzer, Hema Kalyanaraman, Darren E. Casteel, Nancy D. Dalton, Yusu Gu, Seunghoe Lee, Shunhui Zhuang, Nisreen Wahwah, Jan M. Schilling, Hemal H. Patel, Qian Zhang, Ayako Makino, Dianna M. Milewicz, Kirk L. Peterson, Gerry R. Boss, Renate B. Pilz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show that mice carrying the same mutation recapitulate the human disease, and find that treatment with anti-oxidants in
Externí odkaz:
https://doaj.org/article/1bb1d770c1fc4afd9a8c4a6eaa023c6b
Autor:
Julia C. Wilmanns, Raghav Pandey, Olivia Hon, Anjana Chandran, Jan M. Schilling, Elvira Forte, Qizhu Wu, Gael Cagnone, Preeti Bais, Vivek Philip, David Coleman, Heidi Kocalis, Stuart K. Archer, James T. Pearson, Mirana Ramialison, Joerg Heineke, Hemal H. Patel, Nadia A. Rosenthal, Milena B. Furtado, Mauro W. Costa
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 102-114 (2019)
Objective: Congenital heart disease (CHD) is the most frequent birth defect worldwide. The number of adult patients with CHD, now referred to as ACHD, is increasing with improved surgical and treatment interventions. However the mechanisms whereby AC
Externí odkaz:
https://doaj.org/article/54e4286b7710480bb545986201e5fddc