Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Hemal H Mehta"'
Autor:
Hiroshi Kumagai, Su-Jeong Kim, Brendan Miller, Hirofumi Zempo, Kumpei Tanisawa, Toshiharu Natsume, Shin Hyung Lee, Junxiang Wan, Naphada Leelaprachakul, Michi Emma Kumagai, Ricardo Ramirez, II, Hemal H. Mehta, Kevin Cao, Tae Jung Oh, James A. Wohlschlegel, Jihui Sha, Yuichiro Nishida, Noriyuki Fuku, Shohei Dobashi, Eri Miyamoto-Mikami, Mizuki Takaragawa, Mizuho Fuku, Toshinori Yoshihara, Hisashi Naito, Ryoko Kawakami, Suguru Torii, Taishi Midorikawa, Koichiro Oka, Megumi Hara, Chiharu Iwasaka, Yosuke Yamada, Yasuki Higaki, Keitaro Tanaka, Kelvin Yen, Pinchas Cohen
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111212- (2024)
Summary: MOTS-c is a mitochondrial microprotein that improves metabolism. Here, we demonstrate CK2 is a direct and functional target of MOTS-c. MOTS-c directly binds to CK2 and activates it in cell-free systems. MOTS-c administration to mice prevente
Externí odkaz:
https://doaj.org/article/9c8eb5228eec4499b6a78ec85413ec62
Autor:
Tong Xu, Jason A. Junge, Alireza Delfarah, Yi-Tsung Lu, Cosimo Arnesano, Maheen Iqbal, Kevin Delijani, Tien-Chan Hsieh, Emmanuelle Hodara, Hemal H. Mehta, Pinchas Cohen, Nicholas A. Graham, Scott E. Fraser, Amir Goldkorn
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Genetic mutations have long been recognized as drivers of cancer drug resistance, but recent work has defined additional non-genetic mechanisms of plasticity, wherein cancer cells assume a drug resistant phenotype marked by altered epigeneti
Externí odkaz:
https://doaj.org/article/61124d6369024ac5a8162156b065d51c
Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples
Autor:
Brendan Miller, Ana Silverstein, Melanie Flores, Kevin Cao, Hiroshi Kumagai, Hemal H. Mehta, Kelvin Yen, Su- Jeong Kim, Pinchas Cohen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and
Externí odkaz:
https://doaj.org/article/ad2cd95d5924471fa2c8522a8e192362
Autor:
Ana R. Silverstein, Melanie K. Flores, Brendan Miller, Su-Jeong Kim, Kelvin Yen, Hemal H. Mehta, Pinchas Cohen
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss , Pp 132-140 (2020)
Recent advancements in genomic, transcriptomic, proteomic, and metabolomic techniques have prompted fresh inquiry in the field of aging. Here, we outline the application of these techniques in the context of the mitochondrial genome and suggest their
Externí odkaz:
https://doaj.org/article/46373e4dd3e94a9cbbad5a896b630fec
Autor:
Su‐Jeong Kim, Brendan Miller, Hemal H. Mehta, Jialin Xiao, Junxiang Wan, Thalida E. Arpawong, Kelvin Yen, Pinchas Cohen
Publikováno v:
Physiological Reports, Vol 7, Iss 13, Pp n/a-n/a (2019)
Abstract MOTS‐c is an exercise mimetic and improves insulin sensitivity in aged and diet‐induced obese mice. Although plasma markers are good markers for the metabolic condition, whether MOTS‐c changes plasma markers in diet‐induced obese mic
Externí odkaz:
https://doaj.org/article/8047f8fed8d741eabc6a979f46f209b3
Autor:
Hiroshi Kumagai, Su-Jeong Kim, Brendan Miller, Toshiharu Natsume, Shin Hyung Lee, Ayaka Sato, Ricardo Ramirez, Junxiang Wan, Hemal H Mehta, Kelvin Yen, Pinchas Cohen
Publikováno v:
Physiology. 38
MOTS-c is a novel mitochondrial DNA-encoded microprotein and is expressed in several tissues including skeletal muscle. Since the primary function of MOTS-c is to improve aging- and high-fat diet-induced impaired glucose uptake in the skeletal muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::606f12e8e2ee055f509ff4c42084bf42
https://doi.org/10.1152/physiol.2023.38.s1.5725846
https://doi.org/10.1152/physiol.2023.38.s1.5725846
Autor:
Kuk-Wha Lee, Laura J. Cobb, Pinchas Cohen, Gregory Lawson, Joanne J. Sohn, Jonathan Said, Junxiang Wan, Vladislava Paharkova, Colette Galet, Qinglei Gao, Hemal H. Mehta
Supplementary Figure 1 from IGFBP-3 Is a Metastasis Suppression Gene in Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b48acd30c45bc8e6ebe26fc42377877
https://doi.org/10.1158/0008-5472.22388561.v1
https://doi.org/10.1158/0008-5472.22388561.v1
Autor:
Kuk-Wha Lee, Laura J. Cobb, Pinchas Cohen, Gregory Lawson, Joanne J. Sohn, Jonathan Said, Junxiang Wan, Vladislava Paharkova, Colette Galet, Qinglei Gao, Hemal H. Mehta
Supplementary Figure 2 from IGFBP-3 Is a Metastasis Suppression Gene in Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c27421e53764cf1c9b59ba409c6764
https://doi.org/10.1158/0008-5472.22388558.v1
https://doi.org/10.1158/0008-5472.22388558.v1
Autor:
Kuk-Wha Lee, Laura J. Cobb, Pinchas Cohen, Gregory Lawson, Joanne J. Sohn, Jonathan Said, Junxiang Wan, Vladislava Paharkova, Colette Galet, Qinglei Gao, Hemal H. Mehta
Supplementary Material from IGFBP-3 Is a Metastasis Suppression Gene in Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0400549309d19bcde0e13e06c0d87a5b
https://doi.org/10.1158/0008-5472.22388555
https://doi.org/10.1158/0008-5472.22388555
Autor:
Brendan Miller, Thalida E. Arpawong, Henry Jiao, Su-Jeong Kim, Kelvin Yen, Hemal H. Mehta, Junxiang Wan, John C. Carpten, Pinchas Cohen
Publikováno v:
Cells, Vol 8, Iss 4, p 306 (2019)
Mitochondrial genome-wide association studies identify mitochondrial single nucleotide polymorphisms (mtSNPs) that associate with disease or disease-related phenotypes. Most mitochondrial and nuclear genome-wide association studies adjust for genetic
Externí odkaz:
https://doaj.org/article/8dbaca86741a4ffb9294ca368f792920