Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hema Srinath"'
Autor:
Venkataraman Subramanian, Aaron Muth, Sangram S. Parelkar, Mitesh Nagar, Philip S. Kerry, Kathleen W. Clancy, Hema Srinath, Paul A. McEwan, Paul R. Thompson, Edward Beaumont
Publikováno v:
Journal of Medicinal Chemistry. 60:3198-3211
Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective inhibitor has been developed. Such a compound will be critical for elucidatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561b77dfe7b0e745cc01ee7ec0fb4140
https://doi.org/10.1021/acs.jmedchem.7b00274
https://doi.org/10.1021/acs.jmedchem.7b00274
Publikováno v:
Journal of Biological Chemistry. 282:11365-11376
The family of Smad proteins mediates transforming growth factor-beta (TGF-beta) signaling in cell growth and differentiation. Smads repress or activate TGF-beta signaling by interacting with corepressors (e.g. Ski) or coactivators (e.g. CREB-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed90ae6412eb5653890d79b8fc9561d
https://doi.org/10.1074/jbc.m700186200
https://doi.org/10.1074/jbc.m700186200
Autor:
John J. Correia, Kai Lin, Rachel Delston, Hema Srinath, Suvana S. Lam, Bin Y. Qin, Rik Derynck, Cheng Liu
Publikováno v:
Nature Structural & Molecular Biology. 10:913-921
IRF-3, a member of the interferon regulatory factor (IRF) family of transcription factors, functions as a molecular switch for antiviral activity. IRF-3 uses an autoinhibitory mechanism to suppress its transactivation potential in uninfected cells, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea7d319d30dc0c7db293af589ec3dd3
https://doi.org/10.1038/nsb1002
https://doi.org/10.1038/nsb1002
Autor:
Katherine A. Fitzgerald, Celia A. Schiffer, John J. Correia, Kai Lin, William E. Royer, Suvana S. Lam, Weijun Chen, Zhaozhao Jiang, Hema Srinath
Publikováno v:
Nature structuralmolecular biology. 15(11)
Interferon regulatory factors (IRFs) are essential in the innate immune response and other physiological processes. Activation of these proteins in the cytoplasm is triggered by phosphorylation of serine and threonine residues in a C-terminal autoinh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ea37347ee427980af7ee4ffd898f18
https://pubmed.ncbi.nlm.nih.gov/18836453
https://pubmed.ncbi.nlm.nih.gov/18836453
Publikováno v:
Journal of molecular biology. 379(2)
IRF-3, a member of the interferon regulatory factor (IRF) family of transcription factors, functions in innate immune defense against viral infection. Upon infection, host cell IRF-3 is activated by phosphorylation at its seven C-terminal Ser/Thr res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7989513ffee4849bc40eb382a6a227c
https://pubmed.ncbi.nlm.nih.gov/18440553
https://pubmed.ncbi.nlm.nih.gov/18440553
Autor:
Hema Srinath, Katherine A. Fitzgerald, Kai Lin, John J. Correia, Celia A. Schiffer, Zhaozhao Jiang, Weijun Chen, William E. Royer, Suvana S. Lam
Publikováno v:
Biophysical Journal. (3):586a-587a
Members of the Interferon Regulatory Factor (IRF) family of proteins play important roles in development of the immune system, host defense, inflammation and apoptosis. Activation of these proteins in the cytoplasm is triggered by phosphorylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9b0c779c74dcf5e6b3b3575a24c6c7