Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hema S. Krishnan"'
Autor:
Benjamin H. Rotstein PhD, Michael S. Placzek PhD, Hema S. Krishnan PhD, Aleksandra Pekošak MPharm, Thomas Lee Collier PhD, Changning Wang PhD, Steven H. Liang PhD, Ethan S. Burstein PhD, Jacob M. Hooker PhD, Neil Vasdev PhD
Publikováno v:
Molecular Imaging, Vol 15 (2016)
Activation of retinoid X receptors (RXRs) has been proposed as a therapeutic mechanism for the treatment of neurodegeneration, including Alzheimer's and Parkinson's diseases. We previously reported radiolabeling of a Food and Drug Administration-appr
Externí odkaz:
https://doaj.org/article/725b84346084474882a75638559914f5
Autor:
Nicole D. Bartolo, Sarah E. Reid, Hema S. Krishnan, Azra Haseki, Muthukrishnan Renganathan, Tally M. Largent-Milnes, Braxton A. Norwood, Marco L. Loggia, Jacob M. Hooker
Publikováno v:
ACS chemical neuroscience. 13(24)
Voltage-gated sodium channels (Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143513fb1aeceed44f8d0592161670df
https://pubmed.ncbi.nlm.nih.gov/36472927
https://pubmed.ncbi.nlm.nih.gov/36472927
Autor:
Peter J. H. Scott, Debasis Patnaik, Xia Shao, Lucius L Xuan, Nicolas Salem, Phillip S. Sherman, Surya A. Reis, Ashley C Knight, Andrew V. Mossine, Jenelle Stauff, Shil Patel, Peter S. Chindavong, Lisa Wells, David R. Bonsall, Neil Vasdev, Jinshan Michael Chen, Stephen J. Haggarty, Ravi G. Kurumbail, Janna Arteaga, Wen-Ning Zhao, Chialin Cheng, Laurent Martarello, Steven H. Liang, Vadim Bernard-Gauthier, Brenda Amaral, Hema S. Krishnan, Cassis Varlow
Publikováno v:
Journal of Medicinal Chemistry. 62:9600-9617
Using structure-guided design, several cell based assays, and microdosed positron emission tomography (PET) imaging, we identified a series of highly potent, selective, and brain-penetrant oxazole-4-carboxamide-based inhibitors of glycogen synthase k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6f19c69be22ace49ff49e06bec2585
https://doi.org/10.1021/acs.jmedchem.9b01030
https://doi.org/10.1021/acs.jmedchem.9b01030
Publikováno v:
ACS chemical neuroscience. 11(17)
Neurofibrillary tangle (NFT) imaging methods at the distinct scales of atomic and whole-brain resolutions have coevolved rapidly. Linking these two areas of research provides insight into how and why certain tau radiotracers, using positron emission
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aba0ec22c54e12d5f094933b4a15664
https://pubmed.ncbi.nlm.nih.gov/32786315
https://pubmed.ncbi.nlm.nih.gov/32786315
Autor:
Jacob M. Hooker, Zhen Chen, Jing Yang, Chongzhao Ran, Hema S. Krishnan, Neil Vasdev, Kenneth Dahl, Steven H. Liang, E. Livni, Vidya Narayanaswami, Thomas Lee Collier, Vadim Bernard-Gauthier, Michael S. Placzek
Publikováno v:
Molecular Pharmaceutics. 15:695-702
Dyshomeostasis or abnormal accumulation of metal ions such as copper, zinc, and iron have been linked to the pathogenesis of multiple neurodegenerative disorders including Alzheimer’s disease (AD) and Huntington’s disease (HD). 5,7-Dichloro-2-((d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d78f07f56c13d9341e880850e702a46
https://doi.org/10.1021/acs.molpharmaceut.7b00936
https://doi.org/10.1021/acs.molpharmaceut.7b00936
Publikováno v:
Chemistry - A European Journal. 23:15553-15577
Positron emission tomography (PET) imaging study of fluorine-18 labeled biomolecules is an emerging and rapidly growing area for preclinical and clinical research. The present review focuses on recent advances in radiochemical methods for incorporati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdcf556e39c68076e564562dab33a4b
https://doi.org/10.1002/chem.201701581
https://doi.org/10.1002/chem.201701581
Autor:
Stephen J. Haggarty, Neil Vasdev, Zhiqiang Yan, Debasis Patnaik, Steven H. Liang, Benjamin H. Rotstein, Ming-Yu Ngai, Matthew R. Swoyer, Katarzyna N. Lee, Jacob M. Hooker, Thomas Lee Collier, Hema S. Krishnan, Jin Wang, Han Gao, Kongzhen Hu
Publikováno v:
ACS Medicinal Chemistry Letters. 8:287-292
Dysregulation of glycogen synthase kinase-3β (GSK-3β) is implicated in the pathogenesis of neurodegenerative and psychiatric disorders. Thus, development of GSK-3β radiotracers for positron emission tomography (PET) imaging is of paramount importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6652a8beb36894fa75ef05efbb86ea94
https://doi.org/10.1021/acsmedchemlett.6b00405
https://doi.org/10.1021/acsmedchemlett.6b00405
Autor:
Hema S, Krishnan, Vadim, Bernard-Gauthier, Michael S, Placzek, Kenneth, Dahl, Vidya, Narayanaswami, Elijahu, Livni, Zhen, Chen, Jing, Yang, Thomas L, Collier, Chongzhao, Ran, Jacob M, Hooker, Steven H, Liang, Neil, Vasdev
Publikováno v:
Molecular pharmaceutics. 15(2)
Dyshomeostasis or abnormal accumulation of metal ions such as copper, zinc, and iron have been linked to the pathogenesis of multiple neurodegenerative disorders including Alzheimer's disease (AD) and Huntington's disease (HD). 5,7-Dichloro-2-((dimet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5ba820e612fd755e665d93922fd12b3
https://pubmed.ncbi.nlm.nih.gov/29298483
https://pubmed.ncbi.nlm.nih.gov/29298483
Publikováno v:
Chemistry - A European Journal. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96dbcf6d41bf077ecb1a734dbba1b026
https://doi.org/10.1002/chem.201786262
https://doi.org/10.1002/chem.201786262
Publikováno v:
Organic Letters. 14:1146-1149
A domino approach of Heck coupling was used to synthesize β-trifluoromethylstyrene derivatives from iodoarenes and 1-iodo-3,3,3-trifluoropropane in moderate to good yields. This method avoids the use of low-boiling, gaseous reagents such as 3,3,3-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411a0878ac5084fbacd93fa2a3a570e3
https://doi.org/10.1021/ol300076y
https://doi.org/10.1021/ol300076y