Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hema Manjunath"'
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 3134-3146.e6 (2019)
Summary: Sequences within 5′ UTRs dictate the site and efficiency of translation initiation. In this study, an unbiased screen designed to interrogate the 5′ UTR-mediated regulation of the growth-promoting gene MYC unexpectedly revealed the ribos
Externí odkaz:
https://doaj.org/article/40ac48e24b054e6a8a833019b16dd439
Autor:
Joshua T. Mendell, Yang Xie, Dinesh Rakheja, Hema Manjunath, Yangjian Liu, Asha Acharya, Thomas L. Carroll, Harini Ramalingam, James A. Richardson, Robert E. Hammer, Ryan Hunter, He Zhang, Beibei Chen, Benjamin T. Jones
Publikováno v:
Genes & Development. 32:903-908
Loss of function of the DIS3L2 exoribonuclease is associated with Wilms tumor and the Perlman congenital overgrowth syndrome. LIN28, a Wilms tumor oncoprotein, triggers the DIS3L2-mediated degradation of the precursor of let-7, a microRNA that inhibi
Publikováno v:
Cell reports
Cell Reports, Vol 29, Iss 10, Pp 3134-3146.e6 (2019)
Cell Reports, Vol 29, Iss 10, Pp 3134-3146.e6 (2019)
SUMMARY Sequences within 5′ UTRs dictate the site and efficiency of translation initiation. In this study, an unbiased screen designed to interrogate the 5′ UTR-mediated regulation of the growth-promoting gene MYC unexpectedly revealed the riboso
Autor:
Joshua T. Mendell, Tuo Li, Zhijian J. Chen, Florian Kopp, Andres Ramirez-Martinez, Tsung Cheng Chang, Vincent S. Tagliabracci, Yang Xie, Xiang Chen, Beibei Chen, Jiaxi Wu, Juliane Braun, Vanessa Schmid, Hema Manjunath, Ryan J. Golden
Publikováno v:
Nature
MicroRNAs (miRNAs) perform critical functions in normal physiology and disease by associating with Argonaute proteins and downregulating partially complementary messenger RNAs (mRNAs). Here we use clustered regularly interspaced short palindromic rep
Autor:
Ileana Cuevas, Jishnu Mukherjee, Gina M. Aloisio, Christopher G. Peña, James F. Amatruda, Hema Manjunath, Hatice D. Saatcioglu, Anita L Sengupta, Abhijit Bugde, Diego H. Castrillon, Edward D. Tarnawa, Yuji Nakada, F. Kent Hamra, Michael D. Baker
Publikováno v:
The Journal of clinical investigation. 124(9)
Spermatogenesis is a complex, multistep process that maintains male fertility and is sustained by rare germline stem cells. Spermatogenic progression begins with spermatogonia, populations of which express distinct markers. The identity of the sperma
Autor:
Jorge A. Marrero, Adam C. Yopp, Muhammad Shaalan Beg, Hema Manjunath, Purva Gopal, Akbar K. Waljee, Amit G. Singal
Publikováno v:
The American journal of gastroenterology. 109(3)
The PNPLA3 rs738409 single-nucleotide polymorphism is known to promote nonalcoholic steatohepatitis (NASH), but its association with fibrosis severity and hepatocellular carcinoma (HCC) risk is less well-defined. The objectives of this study were to