Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hema J Patel"'
Autor:
David J Hele, Maria G. Belvisi, V Freund-Michel, Hema J Patel, Mark A. Birrell, Natascia Crispino
Publikováno v:
British Journal of Pharmacology. 155:547-557
Background and purpose: Sensory nerves regulate central and local reflexes such as airway plasma protein leakage, bronchoconstriction and cough. Sensory nerve activity may be enhanced during inflammation such that these protective effects become exac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4a777fc3078cf237a3d3675e6875fcd
https://doi.org/10.1038/bjp.2008.298
https://doi.org/10.1038/bjp.2008.298
Publikováno v:
British Journal of Pharmacology. 141:600-609
In the present study, we examined the effect of E-ring 8-isoprostanes on cholinergic neurotransmission in guinea-pig trachea and identified the receptor(s) involved. As isoprostanes are isomeric with prostaglandins, PGE2 and sulprostone (a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b53d7640e59285c3e016d2cdbca475
https://doi.org/10.1038/sj.bjp.0705648
https://doi.org/10.1038/sj.bjp.0705648
Autor:
Hema J Patel, Maria G. Belvisi, Mark A. Birrell, Magdi H. Yacoub, Priya Venkatesan, Natascia Crispino, David J Hele, Peter J. Barnes
Publikováno v:
British Journal of Pharmacology. 140:261-268
1. There is considerable interest in novel therapies for cough, since currently used agents such as codeine have limited beneficial value due to the associated side effects. Sensory nerves in the airways mediate the cough reflex via activation of C-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b94f80269d1b259d094b7a1b70efbc5b
https://doi.org/10.1038/sj.bjp.0705435
https://doi.org/10.1038/sj.bjp.0705435
Autor:
Natascia Crispino, Hema J Patel, David J Hele, Peter J. Barnes, Maria G. Belvisi, Magdi H. Yacoub, Mark A. Birrell
Publikováno v:
British Journal of Pharmacology. 136:620-628
Sensory nerves regulate central and local reflexes such as airway plasma leakage, and cough and their function may be enhanced during inflammation. Evidence suggests that dopamine receptor agonists may inhibit sensory nerve-mediated responses. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f5ed96443715a6d61e5d6d9d2bf8572
https://doi.org/10.1038/sj.bjp.0704758
https://doi.org/10.1038/sj.bjp.0704758
Publikováno v:
European Journal of Pharmacology. 433:231-235
In human airway smooth muscle cells, the levels of RANTES were increased upon stimulation with interleukin-1beta together with tumour necrosis factor-alpha (TNF-alpha) (10 ng ml(-1) for each). In this study, we have assessed the effects of prostaglan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0026d788bbdb6a414407ed57afb35d79
https://doi.org/10.1016/s0014-2999(01)01520-5
https://doi.org/10.1016/s0014-2999(01)01520-5
Publikováno v:
European Journal of Pharmacology. 424:159-162
Elevated levels of nerve growth factor (NGF) have been detected in the bronchoalveolar lavage fluid of patients with asthma. However, the source of this enhanced mediator production is not known. Here, we investigate the production of NGF from a huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6e6f62fd2a7004f1eaaf67a360da78
https://doi.org/10.1016/s0014-2999(01)01138-4
https://doi.org/10.1016/s0014-2999(01)01138-4
Publikováno v:
British Journal of Pharmacology. 128:327-336
The anti-spasmogenic potential of SK&F 94120 (PDE3-selective), rolipram (PDE4-selective), zaprinast (PDE5-selective), zardaverine (dual PDE3/4 inhibitor) and theophylline (non-selective) was evaluated in guinea-pig trachealis. SK&F 94120 or rolipram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d34007324e1ccdf65008f5c36465d6b2
https://doi.org/10.1038/sj.bjp.0702779
https://doi.org/10.1038/sj.bjp.0702779
Autor:
C. M. Herd, Clive P. Page, Mark A. Giembycz, Maria G. Belvisi, Domenico Spina, Hema J Patel, G J Douglas, P. J. Barnes
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 12:245-255
We have assessed the effect of sensitization to allergen on airway smooth muscle responsiveness and acetylcholine (ACh) release from cholinergic nerves in tracheal preparations from rabbits immunized at birth to Alternaria tenuis and littermate contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26acc0288352abcdb2692af95617172
https://doi.org/10.1006/pupt.1999.0204
https://doi.org/10.1006/pupt.1999.0204
Autor:
Hema J Patel, K. Fan Chung, Jonathan Rousell, Maria G. Belvisi, Emma J Fadlon, Jane A. Mitchell, El-Bdaoui Haddad, Peter J. Jose
Publikováno v:
British Journal of Pharmacology. 127:1145-1150
Eotaxin is a novel C-C chemokine with selective chemoattractant activity for eosinophils. We determined whether eotaxin could be produced by human airway smooth muscle (HASM) cells in culture and examined its regulation by interleukin-10 (IL-10) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4adf97906b7e58b363890a34edfb25ab
https://doi.org/10.1038/sj.bjp.0702660
https://doi.org/10.1038/sj.bjp.0702660
Autor:
Hema J Patel, Maria G. Belvisi, Joelle E. Keeling, El-Bdaoui Haddad, Peter J. Barnes, Magdi H. Yacoub
Publikováno v:
British Journal of Pharmacology. 127:413-420
In this study we have evaluated the pharmacological profile of the muscarinic antagonist glycopyrrolate in guinea-pig and human airways in comparison with the commonly used antagonist ipratropium bromide. Glycopyrrolate and ipratropium bromide inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db2e12e752185624b09a11b558331de0
https://doi.org/10.1038/sj.bjp.0702573
https://doi.org/10.1038/sj.bjp.0702573