Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hema Artee Luchman"'
Autor:
Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Hema Artee Luchman, J. Gregory Cairncross, Russell O. Pieper, Joanna J. Phillips, Sabrina M. Ronen
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Background Magnetic resonance spectroscopy (MRS) studies have identified elevated levels of the phospholipid precursor phosphocholine (PC) and phosphoethanolamine (PE) as metabolic hallmarks of cancer. Unusually, however, PC and PE levels ar
Externí odkaz:
https://doaj.org/article/4d65a90d4df8427b87bb1ef73ac45d4b
Autor:
Marina Radoul, Donghyun Hong, Anne Marie Gillespie, Chloé Najac, Pavithra Viswanath, Russell O. Pieper, Joseph F. Costello, Hema Artee Luchman, Sabrina M. Ronen
Publikováno v:
Metabolites, Vol 11, Iss 2, p 109 (2021)
Approximately 80% of low-grade glioma (LGGs) harbor mutant isocitrate dehydrogenase 1/2 (IDH1/2) driver mutations leading to accumulation of the oncometabolite 2-hydroxyglutarate (2-HG). Thus, inhibition of mutant IDH is considered a potential therap
Externí odkaz:
https://doaj.org/article/52f7ab60c27947b18a4eee77a2d83c96
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189670 (2017)
The prognosis for patients diagnosed with glioblastoma multiforme (GBM) remains dismal, with current treatment prolonging survival only modestly. As such, there remains a strong need for novel therapeutic strategies. The janus kinase (JAK)2/signal tr
Externí odkaz:
https://doaj.org/article/85749dfaffab4ae386684434b366d79e
Autor:
Raghu S. Pandurangi, Orsolya Cseh, Hema Artee Luchman, Cynthia Xiuguang Ma, Sanjeewa N. Senadheera, Marcus Laird Forrest
Publikováno v:
ACS Pharmacology & Translational Science. 6:372-386
Autor:
Sabrina M. Ronen, Joanna J. Phillips, Russell O. Pieper, Bo Huang, J. Gregory Cairncross, Hema Artee Luchman, Wei Qiang Ong, Jose Luis Izquierdo-Garcia, Marina Radoul, Pavithra Viswanath
CQ and BAF restore phospholipid levels and inhibit clonogenicity of IDHmut glioma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0e0c68fdaaf1373a28486a224c62ce
https://doi.org/10.1158/0008-5472.22421637
https://doi.org/10.1158/0008-5472.22421637
Autor:
Sabrina M. Ronen, Joanna J. Phillips, Russell O. Pieper, Bo Huang, J. Gregory Cairncross, Hema Artee Luchman, Wei Qiang Ong, Jose Luis Izquierdo-Garcia, Marina Radoul, Pavithra Viswanath
CQ and BAF do not affect ER area or phospholipid levels in IDHwt glioma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f382e48ff81393dfa01705472f05da
https://doi.org/10.1158/0008-5472.22421634.v1
https://doi.org/10.1158/0008-5472.22421634.v1
Autor:
Sabrina M. Ronen, Joanna J. Phillips, Russell O. Pieper, Bo Huang, J. Gregory Cairncross, Hema Artee Luchman, Wei Qiang Ong, Jose Luis Izquierdo-Garcia, Marina Radoul, Pavithra Viswanath
2-HG induces a reduction in ER area in IDHmut glioma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474b948e82e692f60ef321c290d8310b
https://doi.org/10.1158/0008-5472.22421646
https://doi.org/10.1158/0008-5472.22421646
Autor:
Sabrina M. Ronen, Joanna J. Phillips, Russell O. Pieper, Bo Huang, J. Gregory Cairncross, Hema Artee Luchman, Wei Qiang Ong, Jose Luis Izquierdo-Garcia, Marina Radoul, Pavithra Viswanath
Tumor metabolism is reprogrammed to meet the demands of proliferating cancer cells. In particular, cancer cells upregulate synthesis of the membrane phospholipids phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdE) in order to allow for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::176bb167b245d2d38eca7ee3d29ab93b
https://doi.org/10.1158/0008-5472.c.6510978.v1
https://doi.org/10.1158/0008-5472.c.6510978.v1
Autor:
Sabrina M. Ronen, Joanna J. Phillips, Russell O. Pieper, Bo Huang, J. Gregory Cairncross, Hema Artee Luchman, Wei Qiang Ong, Jose Luis Izquierdo-Garcia, Marina Radoul, Pavithra Viswanath
2-HG inhibits PtdCho and PtdE biosynthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07367bb247c9775b42ab0aa67f5c6cfd
https://doi.org/10.1158/0008-5472.22421649.v1
https://doi.org/10.1158/0008-5472.22421649.v1
Autor:
Sabrina M. Ronen, Joanna J. Phillips, Russell O. Pieper, Bo Huang, J. Gregory Cairncross, Hema Artee Luchman, Wei Qiang Ong, Jose Luis Izquierdo-Garcia, Marina Radoul, Pavithra Viswanath
Phospholipid biosynthesis is down-regulated in IDHmut glioma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15e1807c7ecabb8896dc9465ffa4403
https://doi.org/10.1158/0008-5472.22421652
https://doi.org/10.1158/0008-5472.22421652