A phenocopy signature of TP53 loss predicts response to chemotherapy.

Autor: Bakhtiar H; Department of Human Oncology, University of Wisconsin, Madison, WI, USA., Sharifi MN; Department of Medicine, Division of Hematology, Oncology, and Palliative Care, University of Wisconsin, Madison, WI, USA.; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA., Helzer KT; Department of Human Oncology, University of Wisconsin, Madison, WI, USA., Shi Y; Department of Human Oncology, University of Wisconsin, Madison, WI, USA., Bootsma ML; Department of Human Oncology, University of Wisconsin, Madison, WI, USA., Shang TA; Department of Human Oncology, University of Wisconsin, Madison, WI, USA., Chrostek MR; Department of Human Oncology, University of Wisconsin, Madison, WI, USA., Berg TJ; Department of Human Oncology, University of Wisconsin, Madison, WI, USA., Carson Callahan S; Department of Human Oncology, University of Wisconsin, Madison, WI, USA., Carreno V; Department of Medicine, Division of Hematology, Oncology, and Palliative Care, University of Wisconsin, Madison, WI, USA., Blitzer GC; Department of Human Oncology, University of Wisconsin, Madison, WI, USA., West MT; Department of Medicine, Division of Hematology, Oncology, and Palliative Care, University of Wisconsin, Madison, WI, USA., O'Regan RM; Department of Medicine, University of Rochester, Rochester, NY, USA., Wisinski KB; Department of Medicine, Division of Hematology, Oncology, and Palliative Care, University of Wisconsin, Madison, WI, USA.; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA., Sjöström M; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, 94143, USA., Zhao SG; Department of Human Oncology, University of Wisconsin, Madison, WI, USA. shgzhao@humonc.wisc.edu.; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA. shgzhao@humonc.wisc.edu.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. shgzhao@humonc.wisc.edu.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2024 Oct 02; Vol. 8 (1), pp. 220. Date of Electronic Publication: 2024 Oct 02.

Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer.

Autor: Zhao SG; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Madison, WI, USA., Bootsma M; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA., Zhou S; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Shrestha R; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Moreno-Rodriguez T; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Lundberg A; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Pan C; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Arlidge C; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Hawley JR; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Foye A; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Weinstein AS; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Sjöström M; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Zhang M; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Li H; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Chesner LN; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Rydzewski NR; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA.; Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Helzer KT; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA., Shi Y; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA., Lynch M; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Dehm SM; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.; Department of Urology, University of Minnesota, Minneapolis, MN, USA., Lang JM; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA., Alumkal JJ; Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., He HH; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Wyatt AW; Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada.; Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada., Aggarwal R; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Zwart W; Netherlands Cancer Institute, Oncode Institute, Amsterdam, the Netherlands., Small EJ; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Quigley DA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.; Department of Urology, University of California San Francisco, San Francisco, CA, USA., Lupien M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Feng FY; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA. Felix.Feng@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Felix.Feng@ucsf.edu.; Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Felix.Feng@ucsf.edu.; Department of Urology, University of California San Francisco, San Francisco, CA, USA. Felix.Feng@ucsf.edu.

Publikováno v: Nature genetics [Nat Genet] 2024 Aug; Vol. 56 (8), pp. 1689-1700. Date of Electronic Publication: 2024 Jul 17.

Fragmentomic analysis of circulating tumor DNA-targeted cancer panels.

Autor: Helzer KT; Department of Human Oncology, University of Wisconsin, Madison., Sharifi MN; Carbone Cancer Center, University of Wisconsin, Madison; Department of Medicine, University of Wisconsin, Madison, USA., Sperger JM; Department of Medicine, University of Wisconsin, Madison, USA., Shi Y; Department of Human Oncology, University of Wisconsin, Madison., Annala M; Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada; Prostate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere, Finland., Bootsma ML; Department of Human Oncology, University of Wisconsin, Madison., Reese SR; Department of Human Oncology, University of Wisconsin, Madison; Department of Medicine, University of Wisconsin, Madison, USA., Taylor A; Department of Medicine, University of Wisconsin, Madison, USA., Kaufmann KR; Department of Medicine, University of Wisconsin, Madison, USA., Krause HK; Department of Medicine, University of Wisconsin, Madison, USA., Schehr JL; Carbone Cancer Center, University of Wisconsin, Madison., Sethakorn N; Carbone Cancer Center, University of Wisconsin, Madison; Department of Medicine, University of Wisconsin, Madison, USA., Kosoff D; Carbone Cancer Center, University of Wisconsin, Madison; Department of Medicine, University of Wisconsin, Madison, USA., Kyriakopoulos C; Carbone Cancer Center, University of Wisconsin, Madison; Department of Medicine, University of Wisconsin, Madison, USA., Burkard ME; Carbone Cancer Center, University of Wisconsin, Madison; Department of Medicine, University of Wisconsin, Madison, USA., Rydzewski NR; Department of Human Oncology, University of Wisconsin, Madison., Yu M; Carbone Cancer Center, University of Wisconsin, Madison; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison., Harari PM; Department of Human Oncology, University of Wisconsin, Madison; Carbone Cancer Center, University of Wisconsin, Madison., Bassetti M; Department of Human Oncology, University of Wisconsin, Madison; Carbone Cancer Center, University of Wisconsin, Madison., Blitzer G; Department of Human Oncology, University of Wisconsin, Madison; Carbone Cancer Center, University of Wisconsin, Madison., Floberg J; Department of Human Oncology, University of Wisconsin, Madison; Carbone Cancer Center, University of Wisconsin, Madison., Sjöström M; Department of Radiation Oncology, University of California San Francisco, San Francisco; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco., Quigley DA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco; Departments of Epidemiology and Biostatistics; Urology, University of California San Francisco, San Francisco., Dehm SM; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis., Armstrong AJ; Duke Cancer Institute Center for Prostate and Urologic Cancers, Department of Medicine, Duke University, Durham., Beltran H; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston., McKay RR; Moores Cancer Center, University of California San Diego, La Jolla., Feng FY; Department of Radiation Oncology, University of California San Francisco, San Francisco; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis; Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco., O'Regan R; Carbone Cancer Center, University of Wisconsin, Madison; Department of Medicine, University of Wisconsin, Madison, USA; Department of Medicine, University of Rochester, Rochester, USA., Wisinski KB; Carbone Cancer Center, University of Wisconsin, Madison; Department of Medicine, University of Wisconsin, Madison, USA., Emamekhoo H; Carbone Cancer Center, University of Wisconsin, Madison; Department of Medicine, University of Wisconsin, Madison, USA., Wyatt AW; Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada; Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, Canada., Lang JM; Carbone Cancer Center, University of Wisconsin, Madison; Department of Medicine, University of Wisconsin, Madison, USA., Zhao SG; Department of Human Oncology, University of Wisconsin, Madison; Carbone Cancer Center, University of Wisconsin, Madison; William S. Middleton Memorial Veterans' Hospital, Madison, USA. Electronic address: shgzhao@humonc.wisc.edu.

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2023 Sep; Vol. 34 (9), pp. 813-825. Date of Electronic Publication: 2023 Jun 16.

Expression and Therapeutic Targeting of TROP-2 in Treatment-Resistant Prostate Cancer.

Autor: Sperger JM; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Helzer KT; Department of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin., Stahlfeld CN; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Jiang D; Department of Radiology, University of Wisconsin, Madison, Wisconsin.; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong, University of Science and Technology, Wuhan, China., Singh A; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Kaufmann KR; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Niles DJ; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin., Heninger E; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Rydzewski NR; Department of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin., Wang L; Mayo Clinic, Rochester, Minnesota., Wang L; Mayo Clinic, Rochester, Minnesota., Yang R; Masonic Cancer Center and Departments of Laboratory Medicine and Pathology and Urology, University of Minnesota, Minneapolis, Minnesota.; The Hormel Institute, University of Minnesota, Austin, Minnesota., Ren Y; The Hormel Institute, University of Minnesota, Austin, Minnesota., Engle JW; Department of Medical Physics, University of Wisconsin, Madison, Wisconsin., Huang P; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China., Kyriakopoulos CE; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Slovin SF; Memorial Sloan Kettering Cancer Center, New York, New York., Soule HR; Department of Science, Prostate Cancer Foundation, Santa Monica, California., Zhao SG; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin., Kohli M; Mayo Clinic, Rochester, Minnesota., Tagawa ST; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York., Cai W; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Radiology, University of Wisconsin, Madison, Wisconsin.; Department of Medical Physics, University of Wisconsin, Madison, Wisconsin., Dehm SM; Masonic Cancer Center and Departments of Laboratory Medicine and Pathology and Urology, University of Minnesota, Minneapolis, Minnesota., Lang JM; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Jun 13; Vol. 29 (12), pp. 2324-2335.

A clinical-grade liquid biomarker detects neuroendocrine differentiation in prostate cancer.

Autor: Zhao SG; Department of Human Oncology and.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA., Sperger JM; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Schehr JL; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., McKay RR; Moores Cancer Center, University of California, San Diego, La Jolla, California, USA., Emamekhoo H; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Singh A; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Schultz ZD; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Bade RM; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Stahlfeld CN; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Gilsdorf CS; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Hernandez CI; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Wolfe SK; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Mayberry RD; Wisconsin State Lab of Hygiene, Madison, Wisconsin, USA., Krause HM; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Bootsma M; Department of Human Oncology and.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Helzer KT; Department of Human Oncology and.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Rydzewski N; Department of Human Oncology and.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Bakhtiar H; Department of Human Oncology and.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Shi Y; Department of Human Oncology and.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Blitzer G; Department of Human Oncology and.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kyriakopoulos CE; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kosoff D; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Wei XX; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Floberg J; Department of Human Oncology and.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Sethakorn N; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Sharifi M; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Harari PM; Department of Human Oncology and.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Huang W; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Beltran H; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Choueiri TK; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Scher HI; Genitourinary Oncology Service, Department of Medicine and.; Biomarker Development Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Rathkopf DE; Genitourinary Oncology Service, Department of Medicine and., Halabi S; Department of Biostatistics and Bioinformatics and., Armstrong AJ; Duke Cancer Institute Center for Prostate and Urologic Cancers, Department of Medicine, Duke University, Durham, North Carolina, USA., Beebe DJ; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Biomedical Engineering and., Yu M; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA., Sundling KE; Wisconsin State Lab of Hygiene, Madison, Wisconsin, USA.; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Taplin ME; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Lang JM; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2022 Nov 01; Vol. 132 (21). Date of Electronic Publication: 2022 Nov 01.