Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Helsley Grover C"'
Autor:
R. Richard L. Hamer, Lawrence L. Martin, John J. Tegeler, Ellen S. Kurtz, Penelope A. Przekop, Mary Ellen Elliott, Luther Hellyer, Steven C. Bailey, Richard C. Allen, Helsley Grover C, John H. White, Brian S. Freed
Publikováno v:
Journal of Medicinal Chemistry. 39:246-252
Hydroxylamine and hydroxamic acid derivatives of a known nonsteroidal antiinflammatory dibenzoxepine series display both cyclooxygenase (CO) and 5-lipoxygenase (5-LO) inhibitory properties. Many of these new dual CO/5-LO inhibitors also exhibit poten
Autor:
Edward J. Glamkowski, Roy Corbett, Paul G. Conway, Yulin Chiang, Bordeau Kenneth J, Harold B. Hartman, Joseph T. Strupczewski, Mark R. Szewczak, Helsley Grover C, Carole A. Wilmot
Publikováno v:
Journal of Medicinal Chemistry. 38:1119-1131
A series of 3-[[(aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles was synthesized and evaluated as potential antipsychotic D2/5-HT2 antagonists. Most of these compounds showed potent antipsychotic-like activity in an apomorphine-induced climbing mouse p
Autor:
Steven C. Bailey, Luther Hellyer, Penelope A. Przekop, Lawrence L. Martin, John H. White, Mary Ellen Elliott, Brian S. Freed, Helsley Grover C, R. Richard L. Hamer, Ellen S. Kurtz, Richard C. Allen, John J. Tegeler
Publikováno v:
ChemInform. 27
Hydroxylamine and hydroxamic acid derivatives of a known nonsteroidal antiinflammatory dibenzoxepine series display both cyclooxygenase (CO) and 5-lipoxygenase (5-LO) inhibitory properties. Many of these new dual CO/5-LO inhibitors also exhibit poten
Publikováno v:
Journal of Heterocyclic Chemistry; Feb1973, Vol. 10 Issue 1, p65-70, 6p
Publikováno v:
Journal of Medicinal Chemistry. 21:309-312
A series of 3-[2-(phenoxypiperidyl)-ethyl]indoles was synthesized and evaluated for hypotensive activity in the spontaneous hypertensive rat. Maximum hypotensive activity appeared when the phenoxy substituent was para substituted and occupied the 4 p
Autor:
J. C. Wilker, Craig J. Diamond, Helsley Grover C, John J. Tegeler, Theodore C. Spaulding, Hansjeorg Kruse
Publikováno v:
Chemischer Informationsdienst. 16
Several (3-aryl-2,3-dihydrobenzofuran-3-yl)alkanamines, designed as potential antidepressant agents with analgesic properties, were synthesized and pharmacologically evaluated. While two compounds (1a, 1f) displayed potent antitetrabenazine activity,
Autor:
Hansjeorg Kruse, John J. Tegeler, Theodore C. Spaulding, J. C. Wilker, Helsley Grover C, Craig J. Diamond
Publikováno v:
Journal of pharmaceutical sciences. 74(1)
Several (3-aryl-2,3-dihydrobenzofuran-3-yl)alkanamines, designed as potential antidepressant agents with analgesic properties, were synthesized and pharmacologically evaluated. While two compounds (1a, 1f) displayed potent antitetrabenazine activity,
Publikováno v:
Chemischer Informationsdienst. 15
4,10-Dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetic acid (6) was previously reported as a potent antiinflammatory-analgesic agent characterized by an impressive therapeutic ratio in comparison with indomethacin. With the goal of finding compounds
Publikováno v:
Journal of medicinal chemistry. 27(3)
4,10-Dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetic acid (6) was previously reported as a potent antiinflammatory-analgesic agent characterized by an impressive therapeutic ratio in comparison with indomethacin. With the goal of finding compounds
Publikováno v:
Chemischer Informationsdienst. 9
A series of 3-[2-(phenoxypiperidyl)-ethyl]indoles was synthesized and evaluated for hypotensive activity in the spontaneous hypertensive rat. Maximum hypotensive activity appeared when the phenoxy substituent was para substituted and occupied the 4 p