Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Heloisa P Soares"'
Autor:
Ignacio Garrido-Laguna, Asaf Maoz, Wungki Park, Abdul Rafeh Naqash, Vaia Florou, Breelyn Wilky, Jonathan Trent, Umang Swami, Garrett Frampton, Heloisa P Soares, Sonam Puri, Aik Choon Tan, Charalampos S Floudas, Carter Norton, Ethan S Sokol, Peter Hosein, Gilberto de Lima Lopes
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background Pembrolizumab is FDA approved for tumors with tumor mutational burden (TMB) of ≥10 mutations/megabase (mut/Mb). However, the response to immune checkpoint inhibitors (ICI) varies significantly among cancer histologies. We describe the la
Externí odkaz:
https://doaj.org/article/206cd2d9903d405d9e63f577bd3f9aea
Autor:
Ming Ming, James Sinnett-Smith, Jia Wang, Heloisa P Soares, Steven H Young, Guido Eibl, Enrique Rozengurt
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114573 (2014)
Natural products represent a rich reservoir of potential small chemical molecules exhibiting anti-proliferative and chemopreventive properties. Here, we show that treatment of pancreatic ductal adenocarcinoma (PDAC) cells (PANC-1, MiaPaCa-2) with the
Externí odkaz:
https://doaj.org/article/4e0bff5184be43bdbc5c7d44e9f9cd8d
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57289 (2013)
The mTOR pathway is aberrantly stimulated in many cancer cells, including pancreatic ductal adenocarcinoma (PDAC), and thus it is a potential target for therapy. However, the mTORC1/S6K axis also mediates negative feedback loops that attenuate signal
Externí odkaz:
https://doaj.org/article/eef1016954d84ede90343bebb7d38af1
Autor:
Boris G. Naraev, Josh Mailman, Thorvardur R. Halfdanarson, Heloisa P. Soares, Erik S. Mittra, Julie Hallet
Publikováno v:
Expert Review of Anticancer Therapy. 23:601-615
Autor:
Jennifer R Eads, Thorvardur R Halfdanarson, Tim Asmis, Andrew M. Bellizzi, Emily K Bergsland, Arvind Dasari, Ghassan El-Haddad, Michael Frumovittz, Joshua Meyer, Erik Mittra, Sten Myrehaug, Eric Nakakura, Nitya Raj, Heloisa P Soares, Brian Untch, Namrata Vijayvergia, Jennifer A Chan
Publikováno v:
Endocrine-Related Cancer.
High grade neuroendocrine tumors (G3 NET) and neuroendocrine carcinomas (NEC) are a rare disease entity for which there is a limited amount of prospective data available. It has also been relatively recent that a distinction has been made between G3
Autor:
Enrique Rozengurt, James Sinnet-Smith, Liang Han, Steven H. Young, Michelle Mellon, Ming Ming, Heloisa P. Soares
Supplemental Figure S1 Structure of NVP-BEZ235; PKI-587; GDC-0980; PD0325901 and U0126. Supplemental Figure S2 NPV-BEZ235 induces over-activation of ERK phosphorylation in MiaPaCa-2 (A) and PANC-1 (B) cells Supplemental Figure S3 The MEK inhibitor PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349194edae24e65f2600b4c05a23c78b
https://doi.org/10.1158/1535-7163.22500229
https://doi.org/10.1158/1535-7163.22500229
Autor:
Enrique Rozengurt, James Sinnet-Smith, Liang Han, Steven H. Young, Michelle Mellon, Ming Ming, Heloisa P. Soares
Legends for Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9afec561d30c6c7c1f5fcc7049b7b3
https://doi.org/10.1158/1535-7163.22500226.v1
https://doi.org/10.1158/1535-7163.22500226.v1
Autor:
Enrique Rozengurt, James Sinnet-Smith, Liang Han, Steven H. Young, Michelle Mellon, Ming Ming, Heloisa P. Soares
The PI3K/AKT/mTOR pathway, which is aberrantly stimulated in many cancer cells, has emerged as a target for therapy. However, mTORC1/S6K also mediates negative feedback loops that attenuate upstream signaling. Suppression of these feedback loops oppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c05065d96db081657c37cb57f8d3ed
https://doi.org/10.1158/1535-7163.c.6536398
https://doi.org/10.1158/1535-7163.c.6536398
Publikováno v:
Current Treatment Options in Oncology. 23:721-735
The classification of mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) is evolving, and no clear management guidelines are currently available. However, recent studies provide insight into factors affecting outcomes and could help develop tr
Publikováno v:
Endocrine Abstracts.