Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Helmuth Sippel"'
Autor:
Helmuth Sippel
Publikováno v:
Acta Pharmacologica et Toxicologica. 53:135-140
Acute ethanol administration (1.5 g/kg) to fasted rats resulted in a small but significant increase in the content of conjugated dienes in the microsomal fraction of liver. Treatment with 4-methylpyrazole prior to ethanol ingestion was able to reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cef467034c04155f6aee81e23d3d522
https://doi.org/10.1111/j.1600-0773.1983.tb01881.x
https://doi.org/10.1111/j.1600-0773.1983.tb01881.x
Publikováno v:
Journal of Hepatology. 35:46-52
Background/Aims : Females are generally considered to be more susceptible to alcohol-induced liver injury than males. To elucidate whether gonadal hormones are involved, female rats were chronically treated with ethanol and with an antiestrogen. Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d39d7615505adaefe594403ba852b31
https://doi.org/10.1016/s0168-8278(01)00050-2
https://doi.org/10.1016/s0168-8278(01)00050-2
Autor:
Kai O. Lindros, Helmuth Sippel, Magnus Ingelman-Sundberg, Tuomo A. Lukkari, Harri A. Järveläinen, Che Fang
Publikováno v:
Journal of Hepatology. 32:900-910
Background/Aims: Gadolinium chloride inactivates Kupffer cells and alleviates alcohol-induced liver lesions. We investigated the mechanism of gadolinium chloride protection after oral ethanol feeding. Methods: Rats were maintained ethanol-intoxicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e85b923b1c5c9a1a5d9af4cf0a4bca5
https://doi.org/10.1016/s0168-8278(00)80094-x
https://doi.org/10.1016/s0168-8278(00)80094-x
Autor:
Helmuth Sippel, Philippe Lunetta
Publikováno v:
Journal of Forensic and Legal Medicine. 16:397-399
Prostate-specific antigen (PSA) tests are considered a valuable screening method for the forensic examination of semen in vaginal and rectal swabs of alleged victims of sexual abuse. Although these membrane tests have been also applied to autopsy spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46771240ab70695e0b7dc5ddba11cfb9
https://doi.org/10.1016/j.jflm.2009.04.002
https://doi.org/10.1016/j.jflm.2009.04.002
Autor:
Kai O. Lindros, Eeva Kettunen, Concha Muro-Lupori, Helmuth Sippel, Teija Oinonen, Martti Koivusalo
Publikováno v:
Biochemical Pharmacology. 55:413-421
The tumor-associated aldehyde dehydrogenase 3 (ALDH3) and the glutathione transferase (GST)Ya form are coded by members of the Ah (aryl hydrocarbon) battery group of genes activated in the liver by polycyclic hydrocarbons such as 2,3,7,8-tetrachlorod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c5abe9d2920e6851c7e9d7edfe9ec7a
https://doi.org/10.1016/s0006-2952(97)00495-4
https://doi.org/10.1016/s0006-2952(97)00495-4
Publikováno v:
Pharmacologytoxicology. 79(2)
Regional differences in vulnerability to xenobiotic liver damage may relate to the distribution of the detoxication capacity of the glutathione S-transferases (GST). HPLC analysis of cell lysates obtained by digitonin infusion from either the peripor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ee24bb74455c33af6d3f254ac68060
https://pubmed.ncbi.nlm.nih.gov/8878250
https://pubmed.ncbi.nlm.nih.gov/8878250
Publikováno v:
Vision Research. 14:1349-1357
We find that Baumann's (1972) model with appropriate values for the rate constants rather well describes the spectral changes observed after irradiation of frog retinas at varying temperatures (0–25°C) and pH-values (6·0–7·9). The rates of bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18036b2c10868efd200ba42638e43c7
https://doi.org/10.1016/0042-6989(74)90009-1
https://doi.org/10.1016/0042-6989(74)90009-1
Publikováno v:
Brain. 101:701-715
The effect of alcohol was studied in alert monkeys on the cellular mechanisms of the posterior parietal association cortex, a region that normally participates in visuo-spatial co-ordination of hand movements. In thirty-two experiments, the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8dc61050755f0eddc2467f0aea41c79
https://doi.org/10.1093/brain/101.4.701
https://doi.org/10.1093/brain/101.4.701
Autor:
Helmuth Sippel, C.J. Peter Eriksson
Publikováno v:
Biochemical Pharmacology. 26:241-247
An in vivo investigation was made of the distribution of acetaldehyde (AcH) during ethanol metabolism. Different doses of ethanol were administered orally to male and female Sprague-Dawley rats ( n = 96) and AcH measured at various times thereafter i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1072f0574e8c6f77718d04754e21c0c0
https://doi.org/10.1016/0006-2952(77)90310-0
https://doi.org/10.1016/0006-2952(77)90310-0
Autor:
Helmuth Sippel
Publikováno v:
Alcohol. 2:27-30
Depletion of hepatic glutathione in male rats by starvation caused a significant increase in microsomal glutathione S-transferase activity, which was not affected by acute ethanol pretreatment. An additional depletion in fasted rats by diethylmaleate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862c1aabdf18253da30a0f8c775cf8b3
https://doi.org/10.1016/0741-8329(85)90009-6
https://doi.org/10.1016/0741-8329(85)90009-6