Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Helmut Wachtel"'
Autor:
Nils-Erik Andén, Helmut Wachtel
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:310-320
Baclofen (beta-parachlorophenyl-GABA) caused an increase in the concentration of dopamine in the rat brain with a maximum of about 170% of the control value after 1 hr and after doses of 50 mg/kg or more intraperitoneally. The alpha-methyltyrosine-in
Publikováno v:
Acta Pharmacologica et Toxicologica. 44:191-196
Muscimol (3-hydroxy-5-aminomethylisoxazole) at a high dose (10 mg/kg intraperitoneally) elevated the concentration of brain dopamine in rats, decreased the utilization of dopamine and increased the synthesis of dopamine. The utilization of noradrenal
Autor:
Thomas Klockgether, Margrit Kunow, Peter-Andreas Löschmann, Jörg B. Schulz, Helmut Wachtel, Michael T. Heneka, Ullrich Wüllner
Publikováno v:
Synapse. 26:381-391
Stimulation of the dopamine (DA) D-2 and D-1 receptors results in behavioural activation (i.e., induction of contralateral rotations) in 6-hydroxydopamine (6-OHDA) substantia nigra lesioned rats. Competitive N-methyl-D-aspartate (NMDA) antagonists as
Publikováno v:
European Journal of Pharmacology. 284:129-134
In rodent models of Parkinson's disease such as reserpinized or 6-hydroxydopamine substantia nigra lesioned rats, blockade of glutamate receptors of the NMDA (N-methyl- d -aspartate) or the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate) rec
Autor:
Branislava Mitrovic, Herbert Schneider, Helmut Wachtel, Eckhard Ottow, Daryl Faulds, H. Daniel Perez, Dieter Seidelmann, Jenny Tse, Meredith Halks-Miller, David Asarnow, Harald Dinter, Henry Laurent, Vincent K. Tuohy, Peter Esperling, Gerald Kirsch, James Onuffer
Publikováno v:
Journal of neuroimmunology. 108(1-2)
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease with pathological features reminiscent of those seen in multiple sclerosis and thus serves as an animal model for this disease. Inhibition of type IV phosphodiesterase (PDE IV)
Autor:
Emin Sofic, Peter Riederer, Reinhard Horowski, Klaus W. Lange, Karl Theodor Kalveram, Helmut Wachtel, Matthias Burg, Peter-Andreas Löschmann
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 348(6)
Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 102(2)
Effects of terguride, a 9,10-dihydrogenated derivative of lisuride, on the central nervous system were investigated in rodents in comparison with those of lisuride. In vitro binding studies in rat brains showed that terguride, similar to lisuride, ha
Autor:
A. Kupsch, Matthias Burg, Peter-Andreas Löschmann, Petra Renner, Wolfgang H. Oertel, Guy Arnold, Helmut Wachtel, Doris Pufal, Gerrit ten Bruggencate, Hansjorg Sauer
Publikováno v:
Brain research. 592(1-2)
We investigated whether excitatory amino acids acting at the N-methyl-D-aspartate (NMDA) subtype of the L-glutamate receptor contribute to the dopaminergic neurotoxicity induced by systemic administration of the Parkinson's syndrome-inducing toxin 1-
Publikováno v:
Neuroscience letters. 142(2)
Degeneration of dopaminergic nigrostriatal neurons in primate models of Parkinson's disease (PD) leads to an overactivity of excitatory glutamatergic projections from the subthalamic nucleus (STN) to the output nuclei of the basal ganglia resulting i
Autor:
Peter Jenner, C. David Marsden, Klaus W. Lange, Peter Jähnig, P. A. Löschmann, Helmut Wachtel, Reinhard Horowski
Publikováno v:
European journal of pharmacology. 212(2-3)
The mixed dopamine (DA) agonist/antagonist terguride acts as a DA antagonist on normosensitive receptors but shows DA agonistic properties at supersensitive DA receptors. Such a compound could offer an alternative to the treatment of Parkinson's dise