Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Helmut Schwab"'
Publikováno v:
Catalysts, Vol 11, Iss 11, p 1287 (2021)
The active pharmaceutical ingredient levetiracetam has anticonvulsant properties and is used to treat epilepsies. Herein, we describe the enantioselective preparation of the levetiracetam precursor 2-(pyrrolidine-1-yl)butanamide by enzymatic dynamic
Externí odkaz:
https://doaj.org/article/806021d901a34b0cb1bbf25b458befe4
Autor:
Birgit Grill, Maximilian Glänzer, Helmut Schwab, Kerstin Steiner, Daniel Pienaar, Dean Brady, Kai Donsbach, Margit Winkler
Publikováno v:
Molecules, Vol 25, Iss 11, p 2521 (2020)
Nitrile hydratases (NHase) catalyze the hydration of nitriles to the corresponding amides. We report on the heterologous expression of various nitrile hydratases. Some of these enzymes have been investigated by others and us before, but sixteen targe
Externí odkaz:
https://doaj.org/article/3a759537ed4c491084b2d8b1d422c684
Autor:
Tea Pavkov-Keller, Kerstin Steiner, Mario Faber, Martin Tengg, Helmut Schwab, Mandana Gruber-Khadjawi, Karl Gruber
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171056 (2017)
Friedel-Crafts alkylation of aromatic systems is a classic reaction in organic chemistry, for which regiospecific mono-alkylation, however, is generally difficult to achieve. In nature, methyltransferases catalyze the addition of methyl groups to a w
Externí odkaz:
https://doaj.org/article/9fad6ec7b63d4975b0e90a7b5e97f40b
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 10, Iss 16, Pp 58-62 (2014)
Hydroxynitrile lyases (HNLs) are powerful carbon–carbon bond forming enzymes. The reverse of their natural reaction – the stereoselective addition of hydrogen cyanide (HCN) to carbonyls – yields chiral cyanohydrins, versatile building blocks fo
Externí odkaz:
https://doaj.org/article/810ee9088aa546be957f0eb23a1a6d0d
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Oxidative cleavage of alkenes is a widely employed process allowing oxyfunctionalization to corresponding carbonyl compounds. Recently, a novel biocatalytic oxidative alkene cleavage activity on styrene derivatives was identified in TM1459 from Therm
Externí odkaz:
https://doaj.org/article/52b4ca1b7c8f4a7086af151f3d1e48c1
Autor:
Georg Steinkellner, Karl Gruber, Helmut Schwab, Georg M. Guebitz, Rosario Diaz Rodriguez, Annemarie Marold, Sabine Zitzenbacher, Anita Dellacher, Katrin Greimel, Doris Ribitsch, Enrique Herrero Acero
Publikováno v:
Polymers, Vol 4, Iss 1, Pp 617-629 (2012)
A new esterase from Thermobifida halotolerans (Thh_Est) was cloned and expressed in E. coli and investigated for surface hydrolysis of polylactic acid (PLA) and polyethylene terephthalate (PET). Thh_Est is a member of the serine hydrolases superfamil
Externí odkaz:
https://doaj.org/article/13bebbda276748d092afd6cddd272eff
Autor:
Andrzej Łyskowski, Christian Gruber, Georg Steinkellner, Martin Schürmann, Helmut Schwab, Karl Gruber, Kerstin Steiner
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87350 (2014)
Chiral amines are important building blocks for the synthesis of pharmaceutical products, fine chemicals, and agrochemicals. ω-Transaminases are able to directly synthesize enantiopure chiral amines by catalysing the transfer of an amino group from
Externí odkaz:
https://doaj.org/article/d97d7bbb595e42e8a46ceea7ad294efa
Autor:
Kerstin Steiner, Helmut Schwab
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 2, Iss 3, p e201209010 (2012)
Enzymes are an attractive alternative in the asymmetric syntheses of chiral building blocks. To meet the requirements of industrial biotechnology and to introduce new functionalities, the enzymes need to be optimized by protein engineering. This arti
Externí odkaz:
https://doaj.org/article/05a932f5dc674f82bd54dc55e1526021
Autor:
Julia Pitzer, Kerstin Steiner, Christian Schmid, Viktor K. Schein, Christoph Prause, Claudia Kniely, Michaela Reif, Martina Geier, Elena Pietrich, Tamara Reiter, Philipp Selig, Clemens Stückler, Peter Pöchlauer, Georg Steinkellner, Karl Gruber, Helmut Schwab, Anton Glieder, Wolfgang Kroutil
Publikováno v:
Green Chemistry. 24:5171-5180
This work describes the biocatalytic amidation of l-proline with ammonia, resulting in a process with optimized atom efficiency giving prolinamide in an optically pure form (ee >99%). Detailed enzyme and reaction engineering studies are provided.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::436cac56ecd5fa576208de7c8cda7bdd
https://doi.org/10.1039/d2gc00783e
https://doi.org/10.1039/d2gc00783e
Autor:
Simon, Kobalter, Astrid, Radkohl, Helmut, Schwab, Anita, Emmerstorfer-Augustin, Harald, Pichler
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2513
Gene knockout is a key technology in the development of cell factories and basic research alike. The methylotrophic yeast Pichia pastoris is typically employed as a producer of proteins and of fine chemicals, due to its ability to accumulate high cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::061f92cf5d4b82788cbae8530f18fd52
https://pubmed.ncbi.nlm.nih.gov/35781204
https://pubmed.ncbi.nlm.nih.gov/35781204