Zobrazeno 1 - 10 of 157 pro vyhledávání: '"Helmut R. Maecke"'
1
Akademický článek
The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist
Autor: Keelara Abiraj, Samer Ursillo, Maria Luisa Tamma, Svetlana N. Rylova, Beatrice Waser, Edwin C. Constable, Melpomeni Fani, Guillaume P. Nicolas, Jean Claude Reubi, Helmut R. Maecke
Publikováno v: EJNMMI Research, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Background Somatostatin receptor targeting radiopeptides are successfully being used to image, stage, and monitor patients with neuroendocrine tumours. They are exclusively agonists that internalise upon binding to the relevant receptor. Acc
Externí odkaz: https://doaj.org/article/3e6f8fdce56940b8921dfb43b004e7dc
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7
Akademický článek
The somatostatin receptor 2 antagonist 64Cu-NODAGA-JR11 outperforms 64Cu-DOTA-TATE in a mouse xenograft model.
Autor: Svetlana N Rylova, Christian Stoykow, Luigi Del Pozzo, Keelara Abiraj, Maria Luisa Tamma, Yvonne Kiefer, Melpomeni Fani, Helmut R Maecke
Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0195802 (2018)
Copper-64 is an attractive radionuclide for PET imaging and is frequently used in clinical applications. The aim of this study was to perform a side-by-side comparison of the in vitro and in vivo performance of 64Cu-NODAGA-JR11 (NODAGA = 1,4,7-triaza
Externí odkaz: https://doaj.org/article/75175acc042448a59009fd3d214ea109
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8
Akademický článek
Radiochemistry and Preclinical PET Imaging of Ga-Desferrioxamine Radiotracers Targeting Prostate-Specific Membrane Antigen
Autor: Eleni Gourni PhD, Luigi Del Pozzo BSc, Mark Bartholomä PhD, Yvonne Kiefer BSc, Philipp T. Meyer MD, PhD, Helmut R. Maecke PhD, Jason P. Holland D.Phil
Publikováno v: Molecular Imaging, Vol 16 (2017)
Radiotracers incorporating the urea-based Glu-NH-C(O)-NH-Lys group have gained prominence due to their role in targeting prostate-specific membrane antigen (PSMA)—a clinical biomarker of prostate cancer. Here, the synthesis, radiolabeling, and in v
Externí odkaz: https://doaj.org/article/80fc5fd6557c4066a3ee4da24b33cef8
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9
Akademický článek
Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake.
Autor: Tilman Läppchen, Roswitha Tönnesmann, Jos Eersels, Philipp T Meyer, Helmut R Maecke, Svetlana N Rylova
Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170435 (2017)
GLP-1 receptors are ideal targets for preoperative imaging of benign insulinoma and for quantifying the beta cell mass. The existing clinical tracers targeting GLP-1R are all agonists with low specific activity and very high kidney uptake. In order t
Externí odkaz: https://doaj.org/article/ef62f5584b584fdda76a5318d677e015
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10
Detection of Insulinomas Using Dual-Time-Point 68Ga-DOTA-Exendin 4 PET/CT
Autor: Kerstin Michalski, C. Stoykow, Juri Ruf, Katharina Laubner, Helmut R. Maecke, Philipp T. Meyer, Christian Goetz, Mohamed Aymen Omrane, Jochen Seufert
Publikováno v: Clinical Nuclear Medicine. 45:519-524
Purpose Insulinomas are predominantly benign neuroendocrine tumors originating from beta cells within the islets of Langerhans of the endocrine pancreas. Because surgical resection represents the only curative therapy option, exact tumor localization
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97aac8b4b54abd7f240d9a5aac5ddbcb
https://doi.org/10.1097/rlu.0000000000003093
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