Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Helmut Pietschmann"'
Autor:
Anita Willam, Mohammed Aufy, Susan Tzotzos, Dina El-Malazi, Franziska Poser, Alina Wagner, Birgit Unterköfler, Didja Gurmani, David Martan, Shahid Muhammad Iqbal, Bernhard Fischer, Hendrik Fischer, Helmut Pietschmann, Istvan Czikora, Rudolf Lucas, Rosa Lemmens-Gruber, Waheed Shabbir
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Previous in vitro studies have indicated that tumor necrosis factor (TNF) activates amiloride-sensitive epithelial sodium channel (ENaC) current through its lectin-like (TIP) domain, since cyclic peptides mimicking the TIP domain (e.g., solnatide), s
Externí odkaz:
https://doaj.org/article/4ccbfa0917da48fc8e905dbc10f7b2cb
Autor:
Alexander Holzner, Bernhard Fischer, Helmut Pietschmann, Hendrik Fischer, Rudolf Lucas, Waheed Shabbir, Susan Tzotzos, Parastoo Scherbaum-Hazemi, Martin Kraihammer, Rosa Lemmens-Gruber, Mohammad Aufy, Istvan Czikora, Minela Bedak, Anita Willam
Publikováno v:
Biochemical Pharmacology. 98:740-753
Dysfunction of the epithelial sodium channel (ENaC), which regulates salt and water homeostasis in epithelia, causes several human pathological conditions, including pulmonary oedema. This is a potentially lethal complication of acute lung injury at
Autor:
Hendrik Fischer, Bernhard Fischer, Robert Hermann, Hermann Mascher, Richard Schwameis, Sandra Eder, Susan Tzotzos, Markus Zeitlinger, Helmut Pietschmann, Rudolf Lucas
Publikováno v:
The Journal of Clinical Pharmacology. 54:341-350
The diagnosis acute respiratory distress syndrome (ARDS) describes a type of acute diffuse, inflammatory lung injury, leading to increased pulmonary vascular permeability, pulmonary edema, increased lung weight, and loss of aerated lung tissue.1,2 AR
Autor:
Hendrik Fischer, Sabrina Geppert, Anita Willam, Rosa Lemmens-Gruber, Heinrich Evanzin, Waheed Shabbir, Mohammed Aufy, Bernhard Fischer, Rudolf Lucas, Sabine Chytracek, Susan Tzotzos, Istvan Czikora, Helmut Pietschmann
Publikováno v:
Frontiers in Pharmacology
The synthetically produced cyclic peptides solnatide (a.k.a. TIP or AP301) and its congener AP318, whose molecular structures mimic the lectin-like domain of human tumor necrosis factor (TNF), have been shown to activate the epithelial sodium channel
Autor:
Parastoo Scherbaum-Hazemi, Susan Tzotzos, Helmut Pietschmann, Rudolf Lucas, Bernhard Fischer, Rosa Lemmens-Gruber, Hendrik Fischer, Waheed Shabbir
Publikováno v:
Molecular Pharmacology. 84:899-910
AP301 [Cyclo(CGQRETPEGAEAKPWYC)], a cyclic peptide comprising the human tumor necrosis factor lectin-like domain (TIP domain) sequence, is currently being developed as a treatment for lung edema and has been shown to reduce extravascular lung water a
Autor:
Gilles Dupré, Helmut Pietschmann, Hendrik Fischer, Rosa Lemmens-Gruber, Rudolf Lucas, Victoria Prymaka, Waheed Shabbir, Susan Tzotzos, Bernhard Fischer, Parastoo Hazemi
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 26:356-363
Pulmonary permeability oedema is a frequent complication in a number of life-threatening lung conditions, such as ALI and ARDS. Apart from ventilation strategies, no specific therapy yet exists for treatment of these potentially fatal illnesses. The
Autor:
Susan Tzotzos, Helmut Pietschmann, Rudolf Lucas, Rosa Lemmens-Gruber, Gowri Shankar Bagavananthem Andavan, Parastoo Hazemi, Hendrik Fischer, Bernhard Fischer
Publikováno v:
Journal of Medicinal Chemistry. 53:8021-8029
The amiloride-sensitive epithelial sodium channel (ENaC) plays a prominent role in sodium uptake from alveolar fluid, and is the major component in alveolar fluid clearance in normal and diseased lungs. The lectin-like domain of TNF-α has been shown
Autor:
Helmut Pietschmann, Martin Kraihammer, Hendrik Fischer, Bernard M. Fischer, Susan Tzotzos, Aufy Mohammed, Anita Willam, Minela Hasanovic, Rudolf Lucas, Rosa Lemmens-Gruber, Waheed Shabbir
Publikováno v:
The FASEB Journal. 29
Autor:
Waheed Shabbir, Minela Hasanovic, Soja Jenn, Susan Tzotzos, Bernhard Fischer, Helmut Pietschmann, Hendrik Fischer, Rudolf Lucas, Rosa Lemmens‐Gruber
Publikováno v:
The FASEB Journal. 28
Autor:
Richard, Schwameis, Sandra, Eder, Helmut, Pietschmann, Bernhard, Fischer, Hermann, Mascher, Susan, Tzotzos, Hendrik, Fischer, Rudolf, Lucas, Markus, Zeitlinger, Robert, Hermann
Publikováno v:
Journal of clinical pharmacology. 54(3)
AP301 is an activator of ENaC-mediated Na+ uptake for the treatment of pulmonary permeability edema in acute respiratory distress syndrome (ARDS). The purpose of this “first-in-man” study was to examine local and systemic safety and systemic expo