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Akademický článek

From the DNA Gyrase Inhibitor Cyclothialidine to a New Class of Antibacterial Agents

Autor: Erwin Goetschi, Fabienne Ricklin, Peter Reindl, Raffaello Masciadri, Thomas Luebbers, Helmut Link, Dirk Kostrewa, Paul Hebeisen, Hans Gmuender, Peter Angehrn, Frank-Peter Theil

Publikováno v: CHIMIA, Vol 57, Iss 4 (2003)

Cyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from S. filipinensis NR0484. In this account we describe the identification of potent antibacterials structurally derived from this virtually neat enzyme inhibitor.

Externí odkaz: https://doaj.org/article/ebfc36461a92485ba5c717ea4a86a719

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3D-printed porous Ti6Al4V alloys with silver coating combine osteocompatibility and antimicrobial properties

Autor: Anna Diez-Escudero, Brittmarie Andersson, Elin Carlsson, Benjamin Recker, Helmut Link, Josef D. Järhult, Nils P. Hailer

Additive manufacturing allows for the production of porous metallic implants for use in orthopaedics, providing excellent mechanical stability and osseointegration. However, the increased surface area of such porous implants also renders them suscept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17858e7fcc03efe88544261b145fae41
https://hdl.handle.net/2117/382150

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Silver Coatings in Reconstructive Orthopaedics: Basic Science and Clinical Rationale

Autor: Daniel Kendoff, Nemandra A Sandiford, Helmut Link, Bryce Clinger, Dustin L. Richter, Mustafa Citak

Publikováno v: Surgical Technology Online. 39

Prosthetic joint infection (PJI) is one of the most devastating complications that can occur following total hip and total knee arthroplasty. Despite the remarkable advances that have been made in surgical techniques and implant technology, the incid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53c93a65fb88e25130a262c23de5c86d
https://doi.org/10.52198/21.sti.39.os1500

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New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine

Autor: § and Anne Schmitt-Hoffmann, Dirk Kostrewa, Helmut Link, Hans Gmuender, Fabienne Ricklin, Paul Hebeisen, Peter Reindl, Thomas Luebbers, Peter Angehrn, Raffaello Masciadri, Joergen Nielsen, Christoph Funk, Erwin Goetschi, Frank-Peter Theil, Stefan Buchmann

Publikováno v: Journal of Medicinal Chemistry. 47:1487-1513

Cyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensis NR0484 and is a member of a new family of natural products. It acts by competitively inhibiting the ATPase activity exerted by the B sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4dcf48e4c826f95e352489e73ea0ec3
https://doi.org/10.1021/jm0310232

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Cyclothialidine and its congeners: A new class of DNA gyrase inhibitors

Autor: Paul Hebeisen, Helmut Link, Erwin Goetschi, Peter Angehrn, Raffaello Masciadri, Hans Gmuender, Joergen Nielsen

Publikováno v: Pharmacology & Therapeutics. 60:367-380

Cyclothialidine is a new, potent DNA gyrase inhibitor isolated from Streptomyces filipinensis. However, it exhibits hardly any growth-inhibitory activity against intact bacterial cells. To explore its potential with regard to the development of a new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f068eb867c429049fd62052e1289e1
https://doi.org/10.1016/0163-7258(93)90017-8

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Synthese von 2,4-Diamino-thieno[2,3-d]pyrimidin-Derivaten

Autor: Helmut Link

Publikováno v: Helvetica Chimica Acta. 73:797-803

Synthesis of 2,4-Diamino-thieno[2,3-d]pyrimidines Condensation of 2-aminothiophene-3-carbonitrile (4) with guanidine or sequential addition of CS2 and NH3 to 4 provides 2,4-diaminothieno[2,3-d]pyrimidine (7). This compound yields, after sequential ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dfea0257607b93a41731898661ebb2a
https://doi.org/10.1002/hlca.19900730405

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