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pro vyhledávání: '"Helmut Knecht"'
Autor:
Eric Francotte, Danilo Guerini, Markus Streiff, Markus Zollinger, Karl Welzenbach, Rainer Albert, Klaus Hinterding, Trixie Wagner, Helmut Knecht, Nigel Graham Cooke, Frédéric Zecri, Corinne Simeon, Constanze Müller-Hartwieg, Volker Brinkmann
Publikováno v:
Journal of Medicinal Chemistry. 48:5373-5377
In vivo phosphorylation of FTY720 (1) in rats and humans resulted exclusively in the biologically active (S)-configured enantiomer, which was proven by an ex vivo o-phthaldialdehyde derivatization protocol especially elaborated for phosphates of 1. S