Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Helmut Kipp"'
Autor:
Valentin Gorboulev, Jürgen Groll, Hermann Koepsell, Smriti Singh, Helmut Kipp, Rüdiger Pipkorn, Marçal Pastor-Anglada, Chakravarthi Chintalapati, Alexandra Vernaleken, Maike Veyhl-Wichmann, Alexandra Friedrich, Thorsten Keller
Publikováno v:
Molecular Pharmacology. 89:118-132
Cellular uptake adapts rapidly to physiologic demands by changing transporter abundance in the plasma membrane. The human gene RSC1A1 codes for a 67-kDa protein named RS1 that has been shown to induce downregulation of the sodium-D-glucose cotranspor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a333f311a145f97a3db8191421080c
https://doi.org/10.1124/mol.115.101162
https://doi.org/10.1124/mol.115.101162
Autor:
Serge C. Thal, Christoph Sauvant, Maria Gerasimova, Ivan Sabolić, Anne Sebastiani, Ivana Vrhovac, Michael Rose, Hermann Koepsell, Volker Vallon, Davorka Breljak, Daniela Balen Eror, Marija Ljubojević, Hrvoje Brzica, Helmut Kipp
Publikováno v:
American Journal of Physiology-Cell Physiology. 302:C1174-C1188
With a novel antibody against the rat Na+-d-glucose cotransporter SGLT2 (rSGLT2-Ab), which does not cross-react with rSGLT1 or rSGLT3, the ∼75-kDa rSGLT2 protein was localized to the brush-border membrane (BBM) of the renal proximal tubule S1 and S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f935e1dc9071fe23d38b8c7b2ab39c7
https://doi.org/10.1152/ajpcell.00450.2011
https://doi.org/10.1152/ajpcell.00450.2011
Autor:
Dirk Klessen, Stephan Scherneck, Maike Veyhl-Wichmann, Stefan Wiese, Aruna Srinivasan, Alexandra Friedrich, Helen E. Parker, Helmut Kipp, Hermann Koepsell, Fiona M. Gribble, Frank Reimann, Alexander Jaschke, Robyn Cunard, Timo Rieg, Rexhep Rexhepaj, Ivan Sabolić, Michael Sendtner, Daniela Balen, Volker Vallon, Davorka Breljak, Florian Lang, Valentin Gorboulev, Annette Schürmann
Publikováno v:
Diabetes
Diabetes, vol 61, iss 1
Diabetes, vol 61, iss 1
To clarify the physiological role of Na+-d-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1−/− mice were generated and characterized phenotypically. After gavage of d-glucose, small intestinal glucose absorption across the brush-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9de56b6c6750e700615e9a16dd4e60
http://europepmc.org/articles/PMC3237647
http://europepmc.org/articles/PMC3237647
Publikováno v:
Biochemistry. 43:10944-10951
Recently, we identified the extramembranous C-terminus loop 13 of SGLT1 as a binding site for the aromatic glucoside phlorizin, which competitively inhibits sodium D-glucose cotransport. Alkyl glucosides are also competitive inhibitors of the transpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70341acda1f02252ef9d150ccfc3810c
https://doi.org/10.1021/bi049106n
https://doi.org/10.1021/bi049106n
Autor:
Irwin M. Arias, Helmut Kipp
Publikováno v:
Annual Review of Physiology. 64:595-608
▪ Abstract ATP-binding cassette (ABC) transporters located in the hepatocyte canalicular membrane of mammalian liver are critical players in bile formation and detoxification. Although ABC transporters have been well characterized functionally, onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135358998a8a071679bc6de2cc7bdb27
https://doi.org/10.1146/annurev.physiol.64.081501.155793
https://doi.org/10.1146/annurev.physiol.64.081501.155793
Autor:
Evamaria Kinne-Saffran, Stefan H. Boese, Helmut Kipp, Birgit Ruhfus, Rolf K. H. Kinne, Frank Wehner
Publikováno v:
American Zoologist. 41:728-733
In the mammalian kidney renal medullary cells use organic osmolytes such as sorbitol, myo-inositol, glycerophosphorylcholine, betaine, and taurine to adjust their intracellular osmolarity (and thereby their volume) to rapid and drastic changes in ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::979436d4f1b8d0561b65c10beefe841c
https://doi.org/10.1668/0003-1569(2001)041[0728:oocitr]2.0.co
https://doi.org/10.1668/0003-1569(2001)041[0728:oocitr]2.0.co
Autor:
Rolf K. H. Kinne, Helmut Kipp, Birgit Ruhfus, Frank Wehner, Stefan H. Boese, Evamaria Kinne-Saffran
Publikováno v:
American Zoologist. 41:728-733
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::329c3754870b56cb53e6c37cc83865b5
https://doi.org/10.1093/icb/41.4.728
https://doi.org/10.1093/icb/41.4.728
Publikováno v:
Journal of Biological Chemistry. 276:7218-7224
ABC transporter trafficking in rat liver induced by cAMP or taurocholate and [(35)S]methionine metabolic labeling followed by subcellular fractionation were used to identify and characterize intrahepatic pools of ABC transporters. ABC transporter tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03279179a4c8ae7a44b0e832d25d6509
https://doi.org/10.1074/jbc.m007794200
https://doi.org/10.1074/jbc.m007794200
Autor:
Helmut Kipp, Irwin M. Arias
Publikováno v:
Journal of Biological Chemistry. 275:15917-15925
Newly synthesized canalicular ectoenzymes and a cell adhesion molecule (cCAM105) have been shown to traffic from the Golgi to the basolateral plasma membrane, from where they transcytose to the apical bile canalicular domain. It has been proposed tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078f8d8c495eca85b59e29d2f37090a7
https://doi.org/10.1074/jbc.m909875199
https://doi.org/10.1074/jbc.m909875199
Publikováno v:
Cellular Physiology and Biochemistry. 10:371-378
It is well accepted that organic osmolytes, including sorbitol, play a major role in the volume regulation of renal medullary cells. The signal leading to an activation of release channels during RVD is, however, poorly understood. Hypotonicity induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209e239ba63ed90504ecbeaeb8ce299d
https://doi.org/10.1159/000016376
https://doi.org/10.1159/000016376