Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Helmut Dotzlaw"'
Publikováno v:
BioMed Research International. 2014:1-7
The effects of the TNF-αblockers infliximab or etanercept on the levels of TNF-α, TNF-receptor 1 (TNF-R1), and TNF-receptor 2 (TNF-R2), as well as the levels of the inflammation markers CRP and IL-6, were measured in ankylosing spondylitis (AS) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d7878da5e00fa81c0daa42a523a07b
https://doi.org/10.1155/2014/675108
https://doi.org/10.1155/2014/675108
Publikováno v:
Journal of Proteome Research. 6:3752-3759
In a comparative proteome analysis of peripheral blood mononuclear cells (PBMCs), we analyzed 130 two-dimensional gels obtained from 33 healthy control individuals and 32 patients diagnosed with rheumatoid arthritis (RA). We found 16 protein spots th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1b74f53b3beaaada71aa9cd3cfd215
https://doi.org/10.1021/pr070285f
https://doi.org/10.1021/pr070285f
Autor:
Marco Semmler, Helmut Dotzlaw, Gunther Neeck, Ulrike Seeck, Martin Schulz, Beate Neustadt, Martin Eggert
Publikováno v:
Clinical Rheumatology. 26:1499-1504
The aim of this study was to determine the activation level of the pro-inflammatory transcription factor nuclear factor kappaB (NF-kappaB) in lymphocytes of patients with rheumatoid arthritis (RA) before and during an anti-tumor necrosis factor alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3921f5accd3a23361c630a653bdca68
https://doi.org/10.1007/s10067-007-0540-2
https://doi.org/10.1007/s10067-007-0540-2
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1696:121-129
We compared the expression levels of proteins in peripheral blood mononuclear cells (PBMCs) of healthy control individuals to those of patients diagnosed with rheumatoid arthritis (RA) using a proteomics approach. Using two-dimensional electrophoresi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b942a9054409fed07fdc81703114d3f6
https://doi.org/10.1016/j.bbapap.2003.09.015
https://doi.org/10.1016/j.bbapap.2003.09.015
Publikováno v:
Protein Expression and Purification. 26:462-466
We describe here an unusual phenomenon in the isolation of protein complexes from eukaryotic cells using expressed GST-fusion proteins. Protein complexes are involved in a large number of regulatory mechanisms. Therefore, the use of tagged fusion pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a2cf215efddee4d6e84d95e2e02e1e
https://doi.org/10.1016/s1046-5928(02)00556-9
https://doi.org/10.1016/s1046-5928(02)00556-9
Autor:
Helmut Dotzlaw, Aria Baniahmad, Andrew C.B. Cato, Udo Moehren, Jorge A Iñiguez Lluhí, Sigrun Mink
Publikováno v:
Molecular Endocrinology. 16:661-673
Antiandrogens inhibit the ligand-induced transactivation by the androgen receptor (AR) and have a widespread use in the treatment of prostate cancer but their mode of action is not fully understood. Here we show that the ability of the antiandrogen c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64feb5cd301a97635200e566e62f3ed1
https://doi.org/10.1210/mend.16.4.0798
https://doi.org/10.1210/mend.16.4.0798
Publikováno v:
Journal of Molecular Endocrinology. 25:229-242
We have isolated a highly expressed splice variant mRNA of murine estrogen receptor-beta (ERbeta), mERbeta2, containing an in-frame 54 nucleotide insertion between exons 5 and 6 of wild-type mERbeta1. The predicted ERbeta2 protein contains 18 amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d66945789c522df9018b64ba2441baa
https://doi.org/10.1677/jme.0.0250229
https://doi.org/10.1677/jme.0.0250229
Publikováno v:
Molecular and Cellular Endocrinology. 158:153-161
A side-by-side comparison of several normal mouse and human tissues was undertaken in order to determine if exon-deleted variant ER-alpha mRNAs are expressed in the mouse. The data showed that the complex pattern of ER-alpha alternative splicing that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5c71b9f8e6f38c722ebfbbe3b924f3
https://doi.org/10.1016/s0303-7207(99)00169-0
https://doi.org/10.1016/s0303-7207(99)00169-0
Publikováno v:
Scopus-Elsevier
Determination of estrogen receptor alpha (ER) status in breast cancer is an important predictive factor for clinical response to endocrine therapy. We have recently shown that discrepancies in ER status determined by immunohistochemical assay (ER-IHA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0cddb5c6546f2e5f60ae6a95b34eb9
https://doi.org/10.1023/a:1006375902601
https://doi.org/10.1023/a:1006375902601
Autor:
Kate Hole, Peter H. Watson, Etienne Leygue, Sandy Troup, Linda Snell, Leigh C. Murphy, Helmut Dotzlaw, Tamara Hiller-Hitchcock
Publikováno v:
The Journal of Pathology. 189:28-33
The Mammaglobin gene, a breast-specific member of the uteroglobin gene family, has been previously identified as being overexpressed in some breast tumours, but the cellular origin and relationship to tumour progression are unknown. Using a subtracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7668a2413d5d618031c246ad29fb1a47
https://doi.org/10.1002/(sici)1096-9896(199909)189:1<28::aid-path389>3.0.co
https://doi.org/10.1002/(sici)1096-9896(199909)189:1<28::aid-path389>3.0.co