Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Helmut Denk"'
Autor:
Rudolf E. Stauber, Pierre-Emmanuel Rautou, Horia Stefanescu, Adelina Horhat, Maja Thiele, Carolin Lackner, Susan Davies, Helmut Denk, Sönke Detlefsen, Hans Peter Dienes, Viviane Gnemmi, Annette S.H. Gouw, Maria Guido, Rosa Miquel, Valerie Paradis, Ioana Rusu, Peter Schirmacher, Luigi Terracciano, Dina Tiniakos
Publikováno v:
JHEP Reports, Vol 6, Iss 5, Pp 101055- (2024)
Background & Aims: In clinical practice, the diagnosis of alcohol-associated hepatitis (AH) is mostly based on non-invasive criteria, which were defined at a consensus conference by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Thes
Externí odkaz:
https://doaj.org/article/b00cde7b5ddd456b9f59bf55763e6fed
Autor:
Aniket Nikam, Jay V. Patankar, Meghana Somlapura, Pooja Lahiri, Vinay Sachdev, Dagmar Kratky, Helmut Denk, Kurt Zatloukal, Peter M. Abuja
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Chronic intoxication of mice with the porphyrinogenic compound 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) leads to morphological and metabolic changes closely resembling steatohepatitis, a severe form of metabolic liver disease in human
Externí odkaz:
https://doaj.org/article/6aae5e232140418ab452ceedc4722ae2
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12545 (2021)
Understanding the pathomechanism of steatohepatitis (SH) is hampered by the difficulty of distinguishing between causes and consequences, by the broad spectrum of aetiologies that can produce the phenotype, and by the long time-span during which SH d
Externí odkaz:
https://doaj.org/article/9450e15faeb3425791911561c435697c
Autor:
Meghana Somlapura, Benjamin Gottschalk, Pooja Lahiri, Iris Kufferath, Daniela Pabst, Thomas Rülicke, Wolfgang F. Graier, Helmut Denk, Kurt Zatloukal
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6227 (2021)
p62/Sequestosome-1 (p62) is a multifunctional adaptor protein and is also a constant component of disease-associated protein aggregates, including Mallory–Denk bodies (MDBs), in steatohepatitis and hepatocellular carcinoma. We investigated the inte
Externí odkaz:
https://doaj.org/article/81779450aeaa4a999461c6b48b3c28dd
Autor:
Pooja Lahiri, Volker Schmidt, Claudia Smole, Iris Kufferath, Helmut Denk, Pavel Strnad, Thomas Rülicke, Leopold F Fröhlich, Kurt Zatloukal
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161083 (2016)
Mallory-Denk bodies (MDBs) are hepatocytic protein aggregates found in steatohepatitis and several other chronic liver diseases as well as hepatocellular carcinoma. MDBs are mainly composed of phosphorylated keratins and stress protein p62/Sequestoso
Externí odkaz:
https://doaj.org/article/65616c07dc8943bf93ff99b47d7e4526
Autor:
Vikash Pandey, Marc Sultan, Karl Kashofer, Meryem Ralser, Vyacheslav Amstislavskiy, Julia Starmann, Ingrid Osprian, Christina Grimm, Hendrik Hache, Marie-Laure Yaspo, Holger Sültmann, Michael Trauner, Helmut Denk, Kurt Zatloukal, Hans Lehrach, Christoph Wierling
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111006 (2014)
BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) has a broad spectrum of disease states ranging from mild steatosis characterized by an abnormal retention of lipids within liver cells to steatohepatitis (NASH) showing fat accumulation, inflammati
Externí odkaz:
https://doaj.org/article/58d22b0f72e648aea183fa1f9f49a5a3
Publikováno v:
Journal of Hepatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4d79c63059f9b64b8111bdc81ed3a1
https://doi.org/10.1016/j.jhep.2023.03.043
https://doi.org/10.1016/j.jhep.2023.03.043
Autor:
Mattias Mandorfer, Nadine T. Gaisa, Christian Trautwein, Jef Verbeek, Helmut Denk, Daniel Neureiter, Elmar Aigner, Julia Kümpers, Heinz Zoller, Barbara Burbaum, LS Moeller, Heike Bantel, Olivier Govaere, Federica Benini, Joanna Chorostowska-Wynimko, Aleksander Krag, Frank Lammert, Jacob George, Katharina Wöran, Thomas Reiberger, Georg Lurje, Marla Gutberlet, Felix Stickel, Lisa Bewersdorf, Michael Trauner, Mohammed Eslam, V Woditsch, Sabina Janciauskiene, Tania Roskams, V Pereira, Johannes Haybaeck, J. Voss, Karim Hamesch, C Lindhauer, Annika Gross, Andreas Geier, Mònica Pons, Malin Fromme, Alexander Teumer, Quentin M. Anstee, Joan Genescà, Matthias C. Reichert, Biaohuan Zhou, Pawel Kuca, Marcin Krawczyk, Carolin V. Schneider, Pavel Strnad, Timm Dirrichs, Christian Datz, Joana Carvão, Robert Bals, Frederik Nevens, Benedikt Schäfer
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Schneider, C V, Hamesch, K, Gross, A, Mandorfer, M, Moeller, L S, Pereira, V, Pons, M, Kuca, P, Reichert, M C, Benini, F, Burbaum, B, Voss, J, Gutberlet, M, Woditsch, V, Lindhauer, C, Fromme, M, Kümpers, J, Bewersdorf, L, Schäfer, B, Eslam, M, Bals, R, Janciauskiene, S, Carvão, J, Neureiter, D, Zhou, B, Wöran, K, Bantel, H, Geier, A, Dirrichs, T, Stickel, F, Teumer, A, Verbeek, J, Nevens, F, Govaere, O, Krawczyk, M, Roskams, T, Haybaeck, J, Lurje, G, Chorostowska-Wynimko, J, Genesca, J, Reiberger, T, Zoller, H, Lammert, F, Krag, A, George, J, Anstee, Q M, Trauner, M, Datz, C, Gaisa, N T, Denk, H & European Alpha-1 Liver Study Group 2020, ' Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant of AAT (Pi∗MZ vs Pi∗ZZ genotype) and Noncarriers ', Gastroenterology, vol. 159, no. 2, pp. 534-548.e11 . https://doi.org/10.1053/j.gastro.2020.04.058
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Schneider, C V, Hamesch, K, Gross, A, Mandorfer, M, Moeller, L S, Pereira, V, Pons, M, Kuca, P, Reichert, M C, Benini, F, Burbaum, B, Voss, J, Gutberlet, M, Woditsch, V, Lindhauer, C, Fromme, M, Kümpers, J, Bewersdorf, L, Schäfer, B, Eslam, M, Bals, R, Janciauskiene, S, Carvão, J, Neureiter, D, Zhou, B, Wöran, K, Bantel, H, Geier, A, Dirrichs, T, Stickel, F, Teumer, A, Verbeek, J, Nevens, F, Govaere, O, Krawczyk, M, Roskams, T, Haybaeck, J, Lurje, G, Chorostowska-Wynimko, J, Genesca, J, Reiberger, T, Zoller, H, Lammert, F, Krag, A, George, J, Anstee, Q M, Trauner, M, Datz, C, Gaisa, N T, Denk, H & European Alpha-1 Liver Study Group 2020, ' Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant of AAT (Pi∗MZ vs Pi∗ZZ genotype) and Noncarriers ', Gastroenterology, vol. 159, no. 2, pp. 534-548.e11 . https://doi.org/10.1053/j.gastro.2020.04.058
BACKGROUND & AIMS: Homozygosity for the Pi∗Z variant of the gene that encodes the alpha-1 antitrypsin peptide (AAT), called the Pi∗ZZ genotype, causes a liver and lung disease called alpha-1 antitrypsin deficiency. Heterozygosity (the Pi∗MZ gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59dc7827cb0387e946e44ea0d463025
Autor:
Kenneth A Fleming, Marc H Goldinger, Kurt Zatloukal, Robert D. Goldin, Darren Treanor, Clare McGenity, Elizabeth M. Brunt, Jonathan R. Dillman, Caitlin Rose Langford, Helmut Denk, Daniela S. Allende
Publikováno v:
Journal of Clinical Pathology
Non-alcoholic fatty liver disease (NAFLD), a disorder characterised by pathological accumulation of non-visible free fatty acids and visible triglyceride in hepatocytes, is on the rise globally in both adult and paediatric populations.1 Evidence sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106b1c1e06c32690e6cdacfb207505cb
https://doi.org/10.1136/jclinpath-2021-207967
https://doi.org/10.1136/jclinpath-2021-207967
Publikováno v:
Gut
Hepatobiliary Surg Nutr
Hepatobiliary Surg Nutr
Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. Understanding the pathological and molecular hallmarks from its first description to definitions of disease entities, classifications and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80060d6aa01c8c8d54ca96f11cf2ad5
https://doi.org/10.1136/gutjnl-2020-323202
https://doi.org/10.1136/gutjnl-2020-323202