Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Helmut Buschmann"'
Autor:
Alexander Birkmann, Susanne Bonsmann, Dirk Kropeit, Tamara Pfaff, Manickam Rangaraju, Melanie Sumner, Burkhard Timmler, Holger Zimmermann, Helmut Buschmann, Helga Ruebsamen-Schaeff
Publikováno v:
Journal of medicinal chemistry. 65(20)
When the nucleoside analogue acyclovir was introduced in the early 1980s, it presented a game-changing treatment modality for herpes simplex virus infections. Since then, work has been ongoing to improve the weaknesses that have now been identified:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69be1720a16217550c44fc70babd502
https://pubmed.ncbi.nlm.nih.gov/36202389
https://pubmed.ncbi.nlm.nih.gov/36202389
Autor:
Helmut Buschmann, Jonas Urlaub, Everaldo F. Krake, Torsten Beweries, Reinhard P. Kaiser, Laura Backer, Wolfgang Baumann, Ulrike Holzgrabe, Norbert Handler, Carsten Bolm
Publikováno v:
Chemical communications (Cambridge, England). 57(90)
A method for forced oxidative mechanochemical degradation of active pharmaceutical ingredients (APIs) using clopidogrel hydrogensulfate as a model compound is presented. Considerable and selective formation of degradants occurs already after very sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c759acc87d3b9345fd3bb7a5ce891d
https://pubmed.ncbi.nlm.nih.gov/34704567
https://pubmed.ncbi.nlm.nih.gov/34704567
Autor:
Ulrike Holzgrabe, Wolfgang Baumann, Helmut Buschmann, Curd Schollmayer, Detlef Heller, Johannes Wiest, Alexander Becht
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 162:41-46
In the development of new pharmaceutical formulations it is important to consider the possible interactions between the active pharmaceutical ingredient (API) and excipients which is a well-known problem. The objective of the work presented here was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c602578664ac82bb06d1d8e34dc240
https://doi.org/10.1016/j.jpba.2018.09.020
https://doi.org/10.1016/j.jpba.2018.09.020
Publikováno v:
Medchemcomm
Pritelivir (AIC316, BAY 57-1293) was discovered as a highly potent drug against herpes simplex viruses with a novel mode of action, i.e. inhibition of the viral helicase–primase. A side by side comparison of the oral form against Valtrex™ in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02c7848d23b15c63e43732c82ae2c63
https://doi.org/10.1039/c9md00233b
https://doi.org/10.1039/c9md00233b
Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entir
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1103-1119
Pain is the most common reason for patients seeking medical care resulting in an estimated world market for analgesics of more than USD 50 billion. Pain is a highly complex, heterogeneous and dynamic process characterized by specific patterns of phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca70a58d53c705f7049833bfaf829ea
https://doi.org/10.1016/j.bmcl.2015.12.103
https://doi.org/10.1016/j.bmcl.2015.12.103
Autor:
Norbert Handler, Helmut Buschmann
Publikováno v:
Methods and Principles in Medicinal Chemistry ISBN: 9783527674381
Drug Selectivity: An Evolving Concept in Medicinal Chemistry
Drug Selectivity: An Evolving Concept in Medicinal Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b812c7775a70757e96c497ff2d0c7295
https://doi.org/10.1002/9783527674381
https://doi.org/10.1002/9783527674381
Autor:
Gerd Folkers, Helmut Buschmann, Harald H. Sitte, Rasmus P. Clausen, Raimund Mannhold, Gerhard F. Ecker
Publikováno v:
Methods and Principles in Medicinal Chemistry ISBN: 9783527679430
Transporters as Drug Targets
Transporters as Drug Targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4736ca6f0271fe9e203c9109444d24
https://doi.org/10.1002/9783527679430
https://doi.org/10.1002/9783527679430
Autor:
Tamara Pfaff, Schwab Wilfried, Claudiu T. Supuran, Alexander Birkmann, Fabrizio Carta, Holger Zimmermann, Helmut Buschmann, Alfonso Maresca
A series of congeners structurally related to pritelivir, N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide, a helicase-primase inhibitor for the treatment of herpes simplex virus infections, was prepared. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7556a1211b03f00b2455159becadcb18
http://hdl.handle.net/2158/1141163
http://hdl.handle.net/2158/1141163
Autor:
Maria Rocasalbas, Alba Vidal-Torres, Rafael Maldonado, José Miguel Vela, Helmut Buschmann, José M. Baeyens, S.A. Bura, Xavier Codony, Daniel Zamanillo, Manuel Merlos, Luz Romero, Beatriz de la Puente, Clara Touriño, Begoña Fernández-Pastor
Publikováno v:
European Journal of Pharmacology. 711:63-72
While opioids are potent analgesics widely used in the management of pain, a number of well-known adverse effects limit their use. The sigma-1 receptor is a ligand-regulated molecular chaperone involved in pain processing, including modulation of opi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3569efd18364bbb1b51eccb07e186e
https://doi.org/10.1016/j.ejphar.2013.04.018
https://doi.org/10.1016/j.ejphar.2013.04.018