Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Helmut, Schmidhammer"'
Publikováno v:
Molecules, Vol 28, Iss 12, p 4761 (2023)
Opioids are considered the most effective analgesics for the treatment of moderate to severe acute and chronic pain. However, the inadequate benefit/risk ratio of currently available opioids, together with the current ‘opioid crisis’, warrant con
Externí odkaz:
https://doaj.org/article/e78b265ba0fe4ef5af3c578155bc1697
Publikováno v:
Molecules, Vol 27, Iss 3, p 919 (2022)
Accumulated preclinical and clinical data show that peripheral restricted opioids provide pain relief with reduced side effects. The peripherally acting opioid analgesic HS-731 is a potent dual μ-/δ-opioid receptor (MOR/DOR) full agonist, and a wea
Externí odkaz:
https://doaj.org/article/e601a0d177024170ab74c548d581e29a
Autor:
Mariana Spetea, Helmut Schmidhammer
Publikováno v:
ACS Central Science, Vol 5, Iss 6, Pp 936-938 (2019)
Externí odkaz:
https://doaj.org/article/f967031552f1481c947001f9da7bfff5
Autor:
Mariana Spetea, Helmut Schmidhammer
Publikováno v:
Molecules, Vol 26, Iss 18, p 5677 (2021)
Adequate pain management, particularly chronic pain, remains a major challenge associated with modern-day medicine. Current pharmacotherapy offers unsatisfactory long-term solutions due to serious side effects related to the chronic administration of
Externí odkaz:
https://doaj.org/article/bdfc1c2374f1462b816b0c69d231a953
Autor:
Mariana Spetea, Helmut Schmidhammer
Publikováno v:
Molecules, Vol 25, Iss 23, p 5658 (2020)
The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained throughout the years [...]
Externí odkaz:
https://doaj.org/article/bce50dd707fc4705a21274f2bc5a7e2d
Publikováno v:
Molecules, Vol 25, Iss 21, p 5092 (2020)
Among the opioid receptors, the kappa opioid receptor (KOR) has been gaining substantial attention as a promising molecular target for the treatment of numerous human disorders, including pain, pruritus, affective disorders (i.e., depression and anxi
Externí odkaz:
https://doaj.org/article/8978bee2f6f94aca9d878d3b8e7d2144
Autor:
Susanna Fürst, Zoltán S. Zádori, Ferenc Zádor, Kornél Király, Mihály Balogh, Szilvia B. László, Barbara Hutka, Amir Mohammadzadeh, Chiara Calabrese, Anna Rita Galambos, Pál Riba, Patrizia Romualdi, Sándor Benyhe, Júlia Timár, Helmut Schmidhammer, Mariana Spetea, Mahmoud Al-Khrasani
Publikováno v:
Molecules, Vol 25, Iss 11, p 2473 (2020)
There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the management of moderate to severe pain, and their efficacy in the alleviation of pain is wel
Externí odkaz:
https://doaj.org/article/ccf64e1b1f134e5ab7211ab01a32dca6
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs. Opioids are the mainstay f
Externí odkaz:
https://doaj.org/article/80c75f410e494a228656f14578ece010
Autor:
Helmut Schmidhammer, Mariana Spetea
Publikováno v:
Molecules
Molecules, Vol 26, Iss 5677, p 5677 (2021)
Molecules, Vol 26, Iss 5677, p 5677 (2021)
Adequate pain management, particularly chronic pain, remains a major challenge associated with modern-day medicine. Current pharmacotherapy offers unsatisfactory long-term solutions due to serious side effects related to the chronic administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1cf07a6fa869dbdc27e6906d25ac3a
http://europepmc.org/articles/PMC8464912
http://europepmc.org/articles/PMC8464912
Autor:
Tanila Ben Haddou, Szabolcs Béni, Sándor Hosztafi, Davide Malfacini, Girolamo Calo, Helmut Schmidhammer, Mariana Spetea
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99231 (2014)
Morphine and structurally related derivatives are highly effective analgesics, and the mainstay in the medical management of moderate to severe pain. Pharmacological actions of opioid analgesics are primarily mediated through agonism at the µ opioid
Externí odkaz:
https://doaj.org/article/a73325779fbe481cbacb806a8cd04d23