Don't die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?

Autor: Simone Steinbach, Mariana Molina, Lea T Grinberg, Luisa Aring, Annika Guntermann, Katrin Marcus, Helmut Heinsen, Renata E Paraizo Leite, Caroline May

Publikováno v: PLoS ONE, Vol 19, Iss 7, p e0296730 (2024)

A hallmark of Parkinson's disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are affected to the same extent. Studies revealed that neurons located more ventrall

Externí odkaz: https://doaj.org/article/c8e5c7a6e8da40168abe375de7542998

Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation

Autor: Daniela Ushizima, Yuheng Chen, Maryana Alegro, Dulce Ovando, Rana Eser, WingHung Lee, Kinson Poon, Anubhav Shankar, Namrata Kantamneni, Shruti Satrawada, Edson Amaro Junior, Helmut Heinsen, Duygu Tosun, Lea T. Grinberg

Publikováno v: NeuroImage, Vol 248, Iss , Pp 118790- (2022)

Abnormal tau inclusions are hallmarks of Alzheimer's disease and predictors of clinical decline. Several tau PET tracers are available for neurodegenerative disease research, opening avenues for molecular diagnosis in vivo. However, few have been app

Externí odkaz: https://doaj.org/article/20a536662d554a8788d68002459bc1ac

The role of artificial intelligence and machine learning in harmonization of high-resolution post-mortem MRI (virtopsy) with respect to brain microstructure

Autor: Shane O’Sullivan, Helmut Heinsen, Lea Tenenholz Grinberg, Leila Chimelli, Edson Amaro, Paulo Hilário do Nascimento Saldiva, Fleur Jeanquartier, Claire Jean-Quartier, Maria da Graça Morais Martin, Mohammed Imran Sajid, Andreas Holzinger

Publikováno v: Brain Informatics, Vol 6, Iss 1, Pp 1-12 (2019)

Abstract Enhanced resolution of 7 T magnetic resonance imaging (MRI) scanners has considerably advanced our knowledge of structure and function in human and animal brains. Post-industrialized countries are particularly prone to an ever-increasing num

Externí odkaz: https://doaj.org/article/56a92b7337e2437c9474e169bb60a37f

Neuroanatomy of the equine brain as revealed by high-field (3Tesla) magnetic-resonance-imaging.

Autor: Martin J Schmidt, Carola Knemeyer, Helmut Heinsen

Publikováno v: PLoS ONE, Vol 14, Iss 4, p e0213814 (2019)

In this study, the morphology of the horse brain (Equus caballus) is decribed in detail using high field MRI. The study includes sagittal, dorsal, and transverse T2-weighted images at 0.25 mm resolution at 3 Tesla and 3D models of the brain presentin

Externí odkaz: https://doaj.org/article/c95ed5bd8d1b4e66a04cc6175364c395

Is There Any Evidence of Monocytes Involvement in Alzheimer’s Disease? A Pilot Study on Human Postmortem Brain

Autor: Peter Riederer, Tim Hartmann, Simone Bohnert, Sabrina Strobel, Helmut Heinsen, Camelia-Maria Monoranu, Luitpold Distel

Publikováno v: Journal of Alzheimer's Disease Reports
Monoranu, C M, Hartmann, T, Strobel, S, Heinsen, H, Riederer, P, DIstel, L & Bohnert, S 2021, ' Is There Any Evidence of Monocytes Involvement in Alzheimer's Disease? A Pilot Study on Human Postmortem Brain ', Journal of Alzheimer's Disease Reports, vol. 5, no. 1, pp. 887-897 . https://doi.org/10.3233/ADR-210052

Background: The role of neuroinflammation has become more evident in the pathogenesis of neurodegenerative diseases. Increased expression of microglial markers is widely reported in Alzheimer’s disease (AD), but much less is known about the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9eb22a2a14bb96d720cc32b4d12e4b
https://doi.org/10.3233/adr-210052